Ask about this productRelated genes to: FLYWCH2 antibody
- Gene:
- FLYWCH2 NIH gene
- Name:
- FLYWCH family member 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-06-21
- Date modifiied:
- 2014-11-18
Related products to: FLYWCH2 antibody
Related articles to: FLYWCH2 antibody
- Loss of function mutations in the thyroid hormone (TH)-specific cell membrane transporter, the monocarboxylate transporter 8 (MCT8), lead to profound psychomotor retardation and abnormal TH serum levels, with low thyroxine (T4) and high triiodothyronine (T3). Several studies point to impaired TH transport across brain barriers as a crucial pathophysiological mechanism resulting in cerebral hypothyroidism. Treatment options for MCT8-deficient patients are limited and are focused on overcoming the brain barriers. The aim of this study was to evaluate the ability of the TH analog sobetirome and its prodrug Sob-AM2 to access the brain and exert thyromimetic actions in the absence of Mct8. - Source: PubMed
Publication date: 2018/06/29
Bárez-López SoledadHartley Meredith DGrijota-Martínez CarmenScanlan Thomas SGuadaño-Ferraz Ana - Monocarboxylate transporter 8 (MCT8) is a thyroid hormone-specific cell membrane transporter. Mutations in the MCT8 gene lead to profound psychomotor retardation and abnormal thyroid hormone serum levels with low thyroxine (T4) and high triiodothyronine (T3). Currently, therapeutic options for patients are limited. Triiodothyroacetic acid (TRIAC) has potential therapeutic value. The aim of this study was to evaluate the effects and efficacy of therapeutic doses of TRIAC on Mct8-deficient mice (Mct8KO). - Source: PubMed
Publication date: 2016/02/03
Bárez-López SoledadObregon Maria JesusMartínez-de-Mena RaquelBernal JuanGuadaño-Ferraz AnaMorte Beatriz