Ask about this productRelated genes to: FCGR2A antibody
- Gene:
- FCGR2A NIH gene
- Name:
- Fc fragment of IgG receptor IIa
- Previous symbol:
- FCG2, FCGR2A1, FCGR2
- Synonyms:
- CD32, CD32A, IGFR2, CDw32
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-11-30
- Date modifiied:
- 2019-04-23
Related products to: FCGR2A antibody
Related articles to: FCGR2A antibody
- Severe asthma affects 3%-5% of children and may remain uncontrolled despite high-dose inhaled corticosteroids and other controller therapies. Omalizumab, an anti-IgE monoclonal antibody, is approved for children ≥6 years with severe asthma, however treatment response shows substantial interindividual variability. - Source: PubMed
Publication date: 2026/07/21
Rottura MichelangeloPirrotta IgorCullotta ChiaraMarino YleniaSacco Federica MariaGianguzzo Viviana MariaIrrera NatashaArcoraci VincenzoAlibrandi AngelaGalletta FrancescaCorso MarziaLeonardi SalvatoreManti SaraPallio Giovanni - Hepatocellular carcinoma (HCC) is a highly malignant and aggressive tumor. Immune-related genes (IRGs) expression correlates closely with the HCC immune microenvironment, and this study aims to identify immune-related diagnostic markers in HCC. - Source: PubMed
Publication date: 2026/04/30
Li WeiJiang HangDuan JianHe JinlanZhao LipingZhong GuopingFan Chenghu - Entosis is a non-apoptotic form of programmed cell death. Its clinical significance and mechanism of immune microenvironment remodeling in osteosarcoma remain poorly understood. - Source: PubMed
Publication date: 2026/07/06
Huang GuolingXiao YongboZhang HongliangLiu Yu - While the epidemiological association between inflammatory bowel disease (IBD) and stroke is well-established, the shared genetic architecture underlying these diseases remains unclear. This study utilized genome-wide association studies (GWAS) summary statistics to explore genetic overlaps between IBD and stroke subtypes. Mendelian randomization (MR) was applied to assess potential causal relationships. Cross-trait meta-analysis identified shared loci, followed by colocalization testing to pinpoint causal variants. Furthermore, functional prediction analysis of variants and verification through in vitro experiments. Finally, use mediation MR to explore potential mechanisms in multiple dimensions. We identified eight pairs with potential genetic correlations, with common genetic variants contributing more on ulcerative colitis (UC) and multiple stroke subtypes than Crohn's disease (CD). Among them, there is a potential causal relationship between IBD/UC and large arterial atherosclerotic stroke (LAS), which is consistent with previous epidemiological statistics. In addition, one locus (rs7522794) was initially identified through cross-trait analysis, and colocalization pointed out that the variant rs7522794 on the FCGR2A promoter was the culprit of the comorbid phenotype. The rs7522794-T allele predicted to be more prone to bind SPI1, thereby increasing FCGR2A expression and susceptibility to stroke in IBD patients. Finally, evidence suggests that gut microbes, blood metabolites, and immune cells may play a crucial regulatory role in the shared pathophysiology of IBD/UC and LAS. The study highlights the shared genetics architecture that exists between IBD and stroke, and demonstrates two different (FCGR2A-mediated immune pathways and other indirect regulation) but complementary verification mechanisms, providing new insights into IBD-stroke comorbidities. - Source: PubMed
Publication date: 2026/07/04
Wang XinZhu ZijunLi HailongGao JiweiDing MingyangLi YingShi LeiZhu ShimaoCheng Liang - Rheumatoid factor (RF) autoantibodies are highly prevalent, yet the molecular determinants of RF development and its progression to rheumatoid arthritis (RA) remain poorly understood. Here, we define the genetic, phenotypic, and molecular architecture of RF and its progression to RA. - Source: PubMed
Publication date: 2026/06/30
Hocaoglu MehmetSawalha Amr H