Ask about this productRelated genes to: FCGR2A antibody
- Gene:
- FCGR2A NIH gene
- Name:
- Fc fragment of IgG receptor IIa
- Previous symbol:
- FCG2, FCGR2A1, FCGR2
- Synonyms:
- CD32, CD32A, IGFR2, CDw32
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-11-30
- Date modifiied:
- 2019-04-23
Related products to: FCGR2A antibody
Related articles to: FCGR2A antibody
- Platelet-rich fibrin (PRF) is extensively utilized to enhance localized tissue healing, a process that critically depends on the transient polarization of macrophages toward a pro-inflammatory phenotype. Given that PRF, like other blood clot derivatives, may intrinsically modulate macrophage behavior, we conducted a comprehensive screening assay to characterize the global macrophage response to PRF exposure. To this end, we employed two widely used monocytic cell lines-U937 (histiocytic lymphoma) and THP-1 (acute monocytic leukemia)-as models to investigate macrophage responses. Cells were exposed to lysates derived from PRF, and transcriptomic alterations were profiled using bulk RNA sequencing. Differential gene expression analysis was performed, with significance determined by an adjusted p-value threshold of <0.05. In U937-derived macrophages, gene expression profiling revealed a transcriptional signature consistent with inflammatory activation. Clustering of upregulated genes highlighted pathways associated with chemokine activity (e.g., CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL20, CCL23, CCL26, CXCL5, CXCL6, CXCL8, CXCL16, and PPBP), RAGE receptor binding (FPR1, S100A8, S100A9, and S100A12), IgG binding (FCGR1A, FCGR2A, FCGR2B, and FCGR3A), prostaglandin biosynthesis (CBR1, CD74, EDN1, FABP5, IL1B, MIF, PTGES, and PTGS1), and collagen catabolism (CTSL, FAP, MMP3, MMP7, MMP9, MMP12, MMP14, MMP19, and MRC2). In contrast, PRF exposure in THP-1 cells primarily enriched genes involved in steroid biosynthesis, suggesting a more limited or distinct response. These findings underscore U937 cells as a more responsive and appropriate bioassay for modeling inflammatory macrophage polarization in response to PRF. Moreover, the identified gene signatures recapitulate key aspects of early wound healing, providing a relevant platform for studying macrophage reactivation in chronic wound environments. - Source: PubMed
Publication date: 2026/04/22
Panahipour LaylaHuang XiaoyuZampino FrancescaMiron Richard JGruber Reinhard - Crohn's disease (CD) is a chronic, idiopathic inflammatory bowel disease. Understanding the genetic and immunological basis of CD can lead to better therapeutic strategies. - Source: PubMed
Publication date: 2026/04/21
Zhang XinweiLiu LinXu WenyuLi GuangxinQin QiuZhang Jinan - Numerous studies have demonstrated a pathogenic association between rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM), 2 chronic inflammatory diseases. This study integrates transcriptomic and bioinformatic analyses to elucidate the shared molecular mechanisms underlying RA-associated T2DM, aiming to identify effective therapeutic strategies. RNA expression profile datasets for RA and T2DM were downloaded from the gene. Expression Omnibus and Gene Network (Grein) databases. Common differentially expressed genes shared between RA and T2DM were identified and subsequently subjected to gene enrichment analysis, protein-protein interaction network construction, GeneMANIA analysis, immune microenvironment evaluation, and drug prediction. Additionally, the diagnostic performance of hub genes was assessed using receiver operating characteristic curve analysis. Finally, molecular docking was employed to facilitate computer-aided drug design and to investigate drug-gene interactions. We identified 352 common differentially expressed genes, and functional analyses showed that they were mainly involved in the immune regulation of RA-associated T2DM. Thirteen key genes were confirmed through the protein-protein interaction network analysis and validation cohort. Receiver operating characteristic curves confirmed the reliability of their diagnostic value. GeneMANIA analyses suggested these genes were mainly associated with leukocytes, particularly neutrophils. Results from the immune microenvironment revealed abnormal levels of neutrophils in RA and T2DM. Among them, 10 key genes (LYN, TLR1, TLR2, TLR8, FCGR1A, FCGR2A, CCR1, CXCL1, FPR1, and SELL) were considered as neutrophil-related genes. Mechanistically, these genes activate pro-inflammatory signaling pathways, exacerbating tissue inflammation and promoting insulin resistance, ultimately leading to the onset of T2DM, neutrophils play a pivotal role in this process. Drug prediction and molecular docking results indicated that PD-169316 is a potential immunotherapeutic for patients with RA in combination with T2DM. This study concludes that neutrophil-driven inflammatory responses and their associated genes may accelerate the progression of type 2 diabetes caused by RA. - Source: PubMed
Qu XiaochaoZuo XuemeiDu HongChen YixuanZhang QingPeng HuiminMa KeqiangZhang FurongCai YishengTan LijunDeng HongwenChen Xiangding - Immunogenic cell death (ICD) influences tumor immune microenvironment remodeling and immunotherapy response. However, the prognostic value of ICD-related genes in colon cancer has not been systematically clarified. This study aimed to develop an ICD-based prognostic model and explore its association with the immune microenvironment and treatment sensitivity. - Source: PubMed
Publication date: 2026/01/22
Wang HaipengChen NingningWang Weijia - Chimeric antigen receptor macrophages (CAR-Ms) represent a novel approach in cellular immunotherapy. Human pluripotent stem cells (hPSCs) provide an unlimited and renewable cell source, enabling scalable and standardized production of CAR-Ms with consistent quality. - Source: PubMed
Publication date: 2026/01/12
Yang XinzhiLi LuZhu SijingLi ShengtaoWang XinluHan YulingYang Liuliu