Ask about this productRelated genes to: FBXO21 antibody
- Gene:
- FBXO21 NIH gene
- Name:
- F-box protein 21
- Previous symbol:
- -
- Synonyms:
- FBX21, KIAA0875
- Chromosome:
- 12q24.22
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-27
- Date modifiied:
- 2016-10-05
Related products to: FBXO21 antibody
Related articles to: FBXO21 antibody
- SCF (Skp1-Cullin1-Fbox protein) is a multi-subunit RING-type E3 ligase and plays critical roles in various pivotal physiological and pathological processes by mediating the ubiquitination and degradation of key proteins. F-box proteins directly bind substrates, thereby determining their specificity, stability, and function. However, the regulatory mechanisms of FBXO21 degradation in human cancers remain largely elusive. In this study, we demonstrated that Neddylation-ROC1 E3 ligase regulates the protein level of FBXO21. Mechanistic studies revealed that Neddylation-ROC1 targeted FBXO21 for ubiquitination and degradation. Moreover, we found that FBXO21 depletion increased p53 protein stability by delaying its degradation, followed by increasing the transcriptional level of p21. Taken together, our findings reveal a previously unrecognized mechanism by which FBXO21 is regulated by Neddylation modification and regulates the p53-p21 signaling pathway. - Source: PubMed
Zhang YingLi MengDong TiangengZhou YunyangZhang WenjuanChang GailiWang MingsongJia LijunLi Lihui - Sepsis and acute kidney injury (AKI) are life-threatening conditions often coexisting as sepsis-associated AKI (S-AKI). However, their shared molecular mechanisms and immune heterogeneity remain unclear. This study aims to identify robust diagnostic biomarkers applicable to both conditions and to elucidate their diverse immune microenvironments using integrated transcriptomic approaches. - Source: PubMed
Publication date: 2026/07/22
Huang YeqiuFei ShengnanHuang MinminHuang XinzhongLu Fei - Clear cell renal cell carcinoma (ccRCC) is one of the most common cancers in the urinary system. Studies have shown that circRNAs have potential effects in a variety of human tumors. Studying the important signaling pathways and therapeutic targets of circRNAs is essential to increase understanding of ccRCC. In this present study, we clarified that hsa_circGRHL2 was dramatically decreased in ccRCC tissues and cells, which was closely related to the clinicopathological features of ccRCC patients. Functionally, circGRHL2 significantly inhibited the proliferation, migration, and invasion of ccRCC cells in vitro. Mechanistically, circGRHL2 sponges miR-330-5p, could regulate miR-330-5p to affect proliferation, migration, invasion of ccRCC cells and have effect on epithelial-mesenchymal transition (EMT). Moreover, FBXO21, could be a direct target of miR-330-5p, which further reducing P85 phosphorylation, inhibiting PI3K/AKT pathway activation, and weakening the EMT. In addition, circGRHL2 overexpression enhances the sensitivity of 769-P cells to sunitinib and enhances the ability of sunitinib treatment effects in vivo. In summary, we proposed a novel signaling network, in which circGRHL2 inhibited the progression of ccRCC via the miR-330-5p/FBXO21 axis and decreased PI3K/AKT activation. - Source: PubMed
Publication date: 2026/04/29
Gao JieYao HuibaoMao QianchengLiu ChuCui YuanshanZhao JunjieMa JianWu Jitao - Acute kidney injury (AKI) is a serious disease with a high incidence and easy induction. The search for innovative biomarkers and treatment methods is of great significance for improving the prognosis of patients. Autophagy is closely related to the occurrence and development of AKI. This study aims to explore the role of autophagy-related genes (ARGs) as potential biomarkers and therapeutic targets in AKI. - Source: PubMed
Publication date: 2026/02/02
Bai YunqiZhang LiliNie BoSu YixinZhou Jingwei - NMNAT2 is an essential but labile protein required for axon integrity. It is rapidly degraded after nerve injury, promoting axon degeneration. However, the mechanisms regulating NMNAT2 ubiquitination and turnover in neurons remain unclear. In this study, we identify the F-box protein FBXO21 as an NMNAT2-binding protein, and its deficiency confers axonal protection via increasing NMNAT2 abundance. FBXO21 recruits SKP1, CUL1, and RBX1 to form an SCFFBXO21 complex, which promotes NMNAT2 ubiquitination in vivo and in vitro. SCFFBXO21 ubiquitinates NMNAT2 at K155 within an isoform-specific targeting and interaction domain of the family of NMNATs, which underlies the unique labile nature of NMNAT2. The ubiquitination-deficient NMNAT2-K155R exhibits substantially reduced protein turnover and enhanced axon-protective capacity. Finally, in Fbxo21 knockout mice, NMNAT2 levels are markedly increased and the survival of injured sciatic nerves is significantly prolonged. Collectively, our findings reveal a crucial role of FBXO21 in axon degeneration, highlighting the SCFFBXO21 complex as a potential target for modulating NMNAT2-dependent axon survival. - Source: PubMed
Publication date: 2025/09/30
Long WenjingLi ShunyiWang QiangqiangYue WenkaiFu YanbinWang HaiqiongJiang MingshengHu XianyanLi YunxiaCui JihongLi AngZhang YaoyangZhang ZairongFang Yanshan