Ask about this productRelated genes to: ERAS antibody
- Gene:
- ERAS NIH gene
- Name:
- ES cell expressed Ras
- Previous symbol:
- HRAS2, HRASP
- Synonyms:
- -
- Chromosome:
- Xp11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-08-25
Related products to: ERAS antibody
Related articles to: ERAS antibody
- : Endothelial dysfunction is increasingly recognized as a key determinant of transplant outcomes. The Endothelial Activation and Stress Index (EASIX), originally validated in allogeneic stem cell transplantation, integrates markers of endothelial stress into a single composite score. Its prognostic role in autologous stem cell transplantation (ASCT) for multiple myeloma (MM) remains undefined. We evaluated the pre-transplant prognostic value of EASIX, an albumin-modified formulation (mEASIX_alb), and nutritional indices (Prognostic Nutritional Index [PNI] and Controlling Nutritional Status [CONUT] score) in a large MM-ASCT cohort. : We retrospectively analyzed 274 MM patients who underwent ASCT at a single institution. The pre-ASCT EASIX (LDH × Creatinine/Platelets), mEASIX_alb (LDH × Creatinine/[Platelets × Albumin]), PNI (10 × Albumin [g/dL] + 0.005 × Lymphocyte count), and CONUT score were calculated from laboratory values obtained on day 3. Optimal binary cutoffs were determined by maximally selected rank statistics. Overall survival (OS) and progression-free survival (PFS) were analyzed with Cox models in which EASIX and mEASIX_alb were entered as continuous, log-transformed variables; binary cutoffs were used only for descriptive Kaplan-Meier illustration. Internal model validity was assessed by bootstrap resampling (B = 1000). : Over a median follow-up of 81.3 months, 150 patients (54.7%) died, and 207 (75.5%) experienced disease progression or death. Using illustrative cutoffs (EASIX > 0.471, mEASIX_alb > 0.208, PNI < 52.29), higher EASIX was associated with shorter OS (66.7 vs. 108.1 months; = 0.012) and PFS (27.4 vs. 42.7 months; = 0.018). In multivariable analysis, log-transformed EASIX (HR 1.40, 95% CI 1.10-1.77; = 0.006) and mEASIX_alb (HR 1.38, 95% CI 1.09-1.73; = 0.007) independently predicted OS after adjustment for baseline covariates (ISS stage, pre-transplant response, and age). EASIX remained independently prognostic in a day-100 landmark analysis (HR 1.35; = 0.023). Critically, the PNI, prognostic for OS in univariate analysis (HR 0.973; = 0.038), did not provide independent incremental prognostic value beyond the clinical model when EASIX was added (HR 0.99; = 0.526); this does not establish shared information between EASIX and PNI. : Pre-transplant EASIX and mEASIX_alb are independent prognostic biomarkers in MM-ASCT. The PNI did not provide independent incremental prognostic value beyond the clinical model. These scores may inform pre-transplant risk stratification, although the illustrative cutoffs require external validation before clinical use. EASIX retained prognostic significance across transplant eras and in a cytogenetically characterized subset, supporting its era-independent and cytogenetics-independent utility. - Source: PubMed
Publication date: 2026/08/17
Güllü Koca TubaKoca NizameddinHunutlu Fazıl ÇağrıÇubukçu SinemYılmaz RümeysaErsal TubaGürsoy VildanPınar Ibrahim EthemÖzkocaman VildanÖzkalemkaş Fahir - Open surgical repair (OSR) remains an important treatment for abdominal aortic aneurysm (AAA), but its invasiveness contributes to substantial perioperative risk. Although Enhanced Recovery After Surgery (ERAS) pathways have improved outcomes across several surgical specialties, evidence supporting their use in open aortic surgery, particularly in Chinese clinical settings, remains limited. We, therefore, evaluated the association between adherence to a locally adapted ERAS pathway and early perioperative outcomes after elective OSR for AAA. This single-center retrospective cohort study included 182 patients who underwent elective OSR for AAA. Patients who received at least 70% of the 30 ERAS elements were assigned to the ERAS group ( = 93), whereas those who received less than 70% were assigned to the control group ( = 89). A total of 152 patients remained after 1:1 matching of the two groups using propensity score. Quantile regression and logistic regression models were used to evaluate the impact of the ERAS protocol on postoperative length of stay, 30-day mortality, ICU admission rate, hospital cost, major complications, and readmission. After matching, baseline and aneurysm characteristics were generally comparable between groups. The ERAS group demonstrated a significantly reduced risk of major complications (OR = 0.33; 95% CI 0.16-0.71; = 0.004) and postoperative nausea and vomiting (OR = 0.10; 95% CI 0.01-0.80; = 0.030). The time to postoperative bowel movement was 1 day earlier in the ERAS group ( < 0.001). The incidence of postoperative cardiac complications was significantly lower in the ERAS group (2.6% vs. 11.8%; = 0.028). Pulmonary complications were also markedly reduced in the ERAS group (1.3% vs. 19.7%; < 0.001). The ERAS group was associated with a reduction in postoperative length of hospital stay by 2 days ( < 0.001) and a decrease in hospital cost by 8065 RMB ( < 0.001). Higher adherence to a locally adapted ERAS pathway was associated with fewer major complications, faster bowel recovery, shorter postoperative hospitalization, and lower hospital costs after elective open AAA repair. These findings support prospective multicenter evaluation and further context-specific implementation of ERAS in open aortic surgery. - Source: PubMed
Publication date: 2026/08/21
Yang ZhiyiWang QingheLi QingfengCheng XinyuLiu YutongCai JingQiao Tong - Postoperative bleeding and prolonged drainage after head and neck surgery may delay drainage tube removal and hospital discharge, increasing complication risk and resource utilization. Optimizing intra and postoperative hemostasis is essential to facilitate early recovery and support enhanced recovery after surgery (ERAS) pathways. This study aimed to identify factors associated with postoperative drainage and length of hospital stay, with particular focus on energy-based device and fibrin sealant use. Adult patients who underwent neck surgery under general anesthesia with inpatient admission at a tertiary medical center between January 2024 and December 2025 were retrospectively analyzed. Surgical procedures included thyroidectomy ( = 99), parotidectomy ( = 43), submandibular gland excision ( = 25), neck dissection ( = 27) and other procedures ( = 22). Clinical variables, surgical factors, use of energy-based device, hemostatic agents, postoperative drainage volume, and length of hospital stay were collected. Logistic regression analysis was performed to evaluate predictors of early discharge (defined as discharge on postoperative day 1). A total of 216 patients were included. Surgical procedure type was strongly associated with operative duration, postoperative day 1 drainage volume, and length of hospital stay. Neck dissection and total thyroidectomy were associated with increased drainage and prolonged hospitalization. The use of fibrin sealants was independently associated with lower postoperative drainage volume, shorter hospital stay, and a significantly higher likelihood of early discharge (adjusted odds ratio: 4.43, 95% CI 1.92-10.23, < 0.001). Energy-based device use and patient-controlled analgesia were not associated with early discharge. Incorporating fibrin sealant into perioperative management may facilitate safer and earlier discharge, improve patient turnover, and optimize resource utilization within ERAS-based care pathways. - Source: PubMed
Publication date: 2026/08/10
Wen Ming-HsunChen Tzu-AngLi Tzu-HanHung Wei-ChenCheng Ping-ChiaChang Chih-MingLo Wu-ChiaCheng Po-WenWu Po-HsuanLiao Li-Jen - First-generation HS donors fail in pulmonary arterial hypertension (PAH) not due to lack of efficacy, but because they release HS indiscriminately. This review articulates a conceptual framework for advancing HS donor therapy along three complementary directions. Donor 2.0 for precision delivery: Donors remain inert in normal tissues, but release HS upon sensing PAH microenvironment signals [reactive oxygen species (ROS), hypoxia, esterases, matrix metalloproteinases (MMPs)], combined with lesion-selective enrichment and organelle targeting. Donor-endogenous synergy: Move from chronic exogenous supplementation to restoring the patient's own HS synthesis via epigenetic derepression of CSE, oxidative reactivation of CBS, and substrate support for 3-MST. Systemic sensitization: Redefine HS donors as combination enhancers that reverse acquired insensitivity to ERAs, PDE5i, and prostacyclin analogues through protein S-sulfhydration. These three mutually reinforcing dimensions transform HS donors from passive releasers into programmable, context-sensitive therapeutic platforms, addressing the fundamental limitations of current PAH therapies. - Source: PubMed
Publication date: 2026/07/30
Gao ShuangChen XinZhang ChunyuanShen MingliHan Jieru - To evaluate current and emerging perioperative optimization strategies in genitourinary surgery and assess their potential to improve surgical outcomes, particularly in patients with modifiable risk factors. - Source: PubMed
Publication date: 2026/08/12
Yellu AditiWeitzner Aidan SCronin CraigKim Joon KyungLokeshwar Soum D