Ask about this productRelated genes to: EPHX2 antibody
- Gene:
- EPHX2 NIH gene
- Name:
- epoxide hydrolase 2
- Previous symbol:
- -
- Synonyms:
- ABHD20
- Chromosome:
- 8p21.2-p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-26
- Date modifiied:
- 2019-01-28
Related products to: EPHX2 antibody
Related articles to: EPHX2 antibody
- Neohesperidin dihydrochalcone (NHDC) has been confirmed to possess excellent nutritional activities as a natural flavonoid low-calorie sweetener, but its practical application in the food industry was greatly limited due to its low water solubility. The potential NHDC activity against oxidative stress (OS) diseases was explored through network pharmacology and molecular docking technology, and a highly water-soluble NHDC-L-arginine complex (NL) was prepared by combining NHDC with L-arginine to overcome this technical bottleneck. Meanwhile, the enhancement of antioxidant capacity markers under non-stressed conditions following NL treatment was systematically investigated in (), and transcriptomic and metabolomic analyses were integrated to reveal the potential regulatory mechanism at the molecular and metabolic levels. It was found that NHDC could exert potential anti-OS effects by targeting and binding to key proteins such as CYP19A1, TYR, EPHX2, TDP1, ESR1, and SLC5A1. In addition, the MDA level in after NL intervention was significantly reduced to 0.65 ± 0.06 nmol/mg prot, while the activities of antioxidant enzymes T-SOD, GSH-Px, and CAT were significantly increased to 48.83 ± 1.75 U/mg prot, 112.95 ± 0.55 U/mg prot, and 6.30 ± 0.16 U/mg prot, respectively. Longevity regulating pathway-worm was identified as a potential key signaling pathway for NL to regulate the enhancement of antioxidant capacity markers under non-stressed conditions of at the molecular level, and the pentose phosphate pathway was the core metabolic pathway. These results could offer theoretical support for the potential development of NHDC and NL in the field of antioxidants, as well as their large-scale applications in the functional food and flavored food industries. - Source: PubMed
Publication date: 2026/04/04
Chen PingZhu SimingTian MenghanWang YutaoChen LiangWang Zhendong - This study investigated the effect of reducing soluble epoxide hydrolase (sEH, encoded by the gene) on the mediation of EETs metabolism during ferroptosis in emphysema . - Source: PubMed
He XinYang Ai LinYu YueYu Gang GangWu BoLi Yun XiaoWu Yan JunWang Hao YanXu Bo - Uterine corpus endometrial carcinoma (UCEC) is a common gynecologic malignancy characterized by metabolic reprogramming and immune dysregulation. This study aimed to investigate the prognostic and diagnostic value of lipid metabolism- and oxidative stress-related genes (LMOSGs) in UCEC. - Source: PubMed
Publication date: 2026/04/06
Li HongfengBian JiaZhang QinweiDu QiaoWang YijieShang YapingLi Xuehe - Mitochondrial injury plays a critical role in type 2 diabetes mellitus (T2DM) pathogenesis by impairing cellular energy metabolism and insulin sensitivity. The Zhimu-Huangbai herb pair (ZB), a classic Traditional Chinese Medicine formulation composed of Anemarrhena asphodeloides and Phellodendron chinense, has shown efficacy in T2DM, but its molecular mechanisms remain unclear. In this study, we aimed to identify crucial mitochondrial related genes of type 2 diabetes and the potential mechanism of ZB. - Source: PubMed
Publication date: 2026/03/13
Zhang SufangGu MingheChen BaotingLiu YimingLin Aihua - Natural products are a rich sources for developing anti-cancer drugs with low toxicity and high efficiency. Limonin has anti-cancer activity; however, its effect on cervical squamous cell carcinoma remains unreported. The aim of this study was to explore how Limonin affects ferroptosis in cervical squamous cell carcinoma (CESC) and its underlying mechanism. Based on differential gene analysis of the Gene Expression Omnibus database and drug target prediction of the Comparative Toxicogenomics Database, combined with molecular docking technology, potential anti-cancer targets of Limonin were identified. In vitro experiments were conducted to create epoxide hydrolase 2 (EPHX2) knockdown and overexpression cell lines. Relevant phenotypic experiments were conducted to verify how Limonin targeting EPHX2 affects cell proliferation and ferroptosis. Integrated bioinformatic analysis revealed EPHX2 as a key target of Limonin. Functional experiments showed that EPHX2 overexpression inhibited the proliferation of CESC and induced ferroptosis, while Limonin treatment could enhance EPHX2 expression in a concentration-dependent manner. Furthermore, EPHX2 knockdown could reverse the inhibitory effect of Limonin on CESC proliferation and alterations in ferroptosis-related indicators. This study results reveals a new mechanism by which Limonin induces ferroptosis in CESC by activating EPHX2, providing a new strategy for natural compound-based ferroptosis-targeted therapy. - Source: PubMed
Publication date: 2026/03/16
Wu QiBai SuningWang PeiHan LinaSong LiyunSu LuyangRen Yanan