Ask about this productRelated genes to: EPHX2 antibody
- Gene:
- EPHX2 NIH gene
- Name:
- epoxide hydrolase 2
- Previous symbol:
- -
- Synonyms:
- ABHD20
- Chromosome:
- 8p21.2-p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-26
- Date modifiied:
- 2019-01-28
Related products to: EPHX2 antibody
Related articles to: EPHX2 antibody
- Epoxide hydrolases (EHs) constitute a conserved enzyme family that catalyzes the hydrolysis of epoxides into less reactive diols. Beyond their canonical roles in xenobiotic detoxification, EHs have emerged as critical regulators of lipid metabolism, redox balance, and inflammatory signaling. Accumulating evidence implicates EH family members, particularly Ephx1 (microsomal EH) and Ephx2 (soluble EH), in cardiovascular diseases, cancer, neurodegeneration, metabolic disorders, and other pathological conditions. More recently, studies have uncovered specialized functions of Ephx3 and Ephx4, broadening our understanding of EH biology and highlighting their tissue-specific roles in skin homeostasis and lipid signaling. Here, we systematically review the structural features, catalytic mechanisms, and physiological functions of EHs, with an emphasis on their regulatory networks in human diseases. We further discuss advances in genetic, epigenetic, and translational studies that connect EHs to disease susceptibility and progression. Finally, we evaluate the therapeutic potential and challenges of targeting EHs, particularly soluble EH inhibitors, and propose future research directions to bridge basic discoveries with clinical translation. This review aims to provide a comprehensive framework for understanding the multifaceted roles of EHs and to inspire novel strategies for precision medicine. - Source: PubMed
Publication date: 2026/04/28
Tan YadanXu JingjingHuang ZitengWang XiranXing JinshanLi ShengbiaoYi Jingyan - Sepsis is a major global health challenge characterized by a complex pathogenesis involving an early hyperinflammatory phase followed by a subsequent immunosuppressive state. Recent studies have revealed that dysregulation of fumarate metabolism plays a central role in immune dysregulation during sepsis, making related genes promising candidates as novel diagnostic biomarkers and therapeutic targets. - Source: PubMed
Publication date: 2026/05/11
Li MingZhao TingtingSun JingWang YunhuiShen Lin - Hepatocellular carcinoma (HCC) exhibits substantial metabolic plasticity that supports tumor progression and therapeutic resistance. LGALS3BP has been primarily characterized as a secreted immunomodulatory protein; however, its cell-intrinsic role in regulating subcellular organization and metabolism in HCC remains poorly understood. - Source: PubMed
Hwang Jun EulShim Hyun JeongBang Hyun JinKim Hyeon-JongJung Sung YunChung Ik-JooCho Sang-HeeKim Dae-Hwan - Neohesperidin dihydrochalcone (NHDC) has been confirmed to possess excellent nutritional activities as a natural flavonoid low-calorie sweetener, but its practical application in the food industry was greatly limited due to its low water solubility. The potential NHDC activity against oxidative stress (OS) diseases was explored through network pharmacology and molecular docking technology, and a highly water-soluble NHDC-L-arginine complex (NL) was prepared by combining NHDC with L-arginine to overcome this technical bottleneck. Meanwhile, the enhancement of antioxidant capacity markers under non-stressed conditions following NL treatment was systematically investigated in (), and transcriptomic and metabolomic analyses were integrated to reveal the potential regulatory mechanism at the molecular and metabolic levels. It was found that NHDC could exert potential anti-OS effects by targeting and binding to key proteins such as CYP19A1, TYR, EPHX2, TDP1, ESR1, and SLC5A1. In addition, the MDA level in after NL intervention was significantly reduced to 0.65 ± 0.06 nmol/mg prot, while the activities of antioxidant enzymes T-SOD, GSH-Px, and CAT were significantly increased to 48.83 ± 1.75 U/mg prot, 112.95 ± 0.55 U/mg prot, and 6.30 ± 0.16 U/mg prot, respectively. Longevity regulating pathway-worm was identified as a potential key signaling pathway for NL to regulate the enhancement of antioxidant capacity markers under non-stressed conditions of at the molecular level, and the pentose phosphate pathway was the core metabolic pathway. These results could offer theoretical support for the potential development of NHDC and NL in the field of antioxidants, as well as their large-scale applications in the functional food and flavored food industries. - Source: PubMed
Publication date: 2026/04/04
Chen PingZhu SimingTian MenghanWang YutaoChen LiangWang Zhendong - This study investigated the effect of reducing soluble epoxide hydrolase (sEH, encoded by the gene) on the mediation of EETs metabolism during ferroptosis in emphysema . - Source: PubMed
He XinYang Ai LinYu YueYu Gang GangWu BoLi Yun XiaoWu Yan JunWang Hao YanXu Bo