Ask about this productRelated genes to: ENPEP antibody
- Gene:
- ENPEP NIH gene
- Name:
- glutamyl aminopeptidase
- Previous symbol:
- -
- Synonyms:
- gp160, CD249
- Chromosome:
- 4q25
- Locus Type:
- gene with protein product
- Date approved:
- 1993-04-15
- Date modifiied:
- 2016-01-06
Related products to: ENPEP antibody
Related articles to: ENPEP antibody
- Hexavalent chromium (Cr(VI)) is a widely present carcinogenic environmental pollutant, has demonstrated well-documented neurotoxic and enterotoxic effects in aquatic organisms, yet limited research exists on mitigating its toxicity through brain-gut-microbiota axis regulation. Vitamin C (VC), a potent antioxidant and immunomodulator, has shown potential in mitigating heavy metal toxicity. Nevertheless, how VC regulates Cr(VI) toxicity via the brain-gut-microbiota axis remains unclear. To investigate VC's potential protective role, adult zebrafish were divided into three groups: control, 2 mg/L Cr(VI), 2 mg/L Cr(VI) + 2 mg/L VC groups, with a 60-day exposure period. Histopathological changes, 16S rRNA, intestinal, and brain RNA-sequencing were examined. The results showed that VC modulated neuropathological lesions and intestinal goblet cell vacuolization caused by Cr(VI). 16S rRNA further confirmed VC partially modulated microbiota homeostasis. Transcriptomic analysis identified 78 differentially expressed genes (DEGs) in the brain; KEGG enrichment analysis showed these DEGs are associated with neurological function and gastrointestinal carcinogenesis pathways. Concurrently, 52 DEGs in intestinal were linked to viral infection and neural signaling pathways. Correlation analyses demonstrated pathogenic Aeromonas was positively correlated with ace, enpep, prss1, asah2, and cd36 in the brain, those are downregulated DEGs, whereas beneficial Pseudomonas was positively correlated with c6ast4 and nfe211b in intestinal, they are upregulated DEGs. This indicates Aeromonas and Pseudomonas could act as key mediators through which VC reduces Cr(VI)-induced neuro- and immunotoxicity. Collectively, these findings provide mechanistic insights into VC's protective role against parallel disruptions along the microbiota-gut-brain axis, suggesting its potential as a waterborne supplement for reducing Cr(VI) toxicity in aquaculture system. - Source: PubMed
Publication date: 2026/03/28
Lu Guan-LingZhao Ying-HuiRuan Yu-QiNing JingWei Lu - Heart failure (HF) and various arrhythmias frequently co-occur in clinical practice, suggesting shared pathophysiological mechanisms. However, the extent and nature of their common genetic architecture remains incompletely understood. This study aimed to systematically investigate the genetic correlations and shared causal loci between HF-related traits and multiple arrhythmia phenotypes. - Source: PubMed
Publication date: 2026/03/18
Xia ZhihengFeng ZianLi AngSu Hao - To dissect the molecular mechanisms underlying chicken cecal development, this study used Liangshan Yanying chickens (a local slow-growing breed) and Arbor Acres (AA) chickens (a fast-growing breed) as experimental models. Cecal tissues were collected from healthy chickens at 1, 14, and 28 days of age ( = 10 per breed per day of age) to measure cecal length and perform transcriptome sequencing. Through the screening of differentially expressed genes (DEGs), functional enrichment analysis, construction of protein-protein interaction (PPI) networks, and qRT-PCR validation, temporal changes in cecal development between the two breeds were systematically compared. Results showed that cecal length of both breeds increased significantly with age ( < 0.05), with significant differences between breeds. A total of 18 high-quality samples were obtained from transcriptome analysis (Q30 ≥ 93%), with a mapping efficiency of 86.2-90.5%. The number of DEGs was highest between 1 and 28 days of age (1844 DEGs in Liangshan Yanying chickens and 1747 DEGs in AA chickens), and the number of inter-breed DEGs reached 2133 at 28 days of age. A total of 70 DEGs with consistent expression trends were identified (22 upregulated and 48 downregulated), which were enriched in Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways such as "B cell activation", "peptide transport", and "bile acid metabolism". qRT-PCR validation indicated that the expression trends of genes (e.g., CD79B, IRF4) were highly consistent with sequencing results (R = 0.91). PPI network analysis suggested that SLC15A1, ACE, and ENPEP were key hub genes, forming a "transport-metabolism" synergistic module. This study reveals the temporal dynamics of chicken cecal development and the molecular basis of inter-breed differences, providing a theoretical foundation for broiler genetic improvement. - Source: PubMed
Publication date: 2026/02/03
Huang ZengwenWang JingYang ChaoyunWang Runjin - Breast cancer (BC) remains a leading cause of cancer-related mortality in women, with treatment challenges due to the lack of targeted therapies. Extracellular vesicles (EVs) play a crucial role in BC progression by carrying bioactive molecules. This study analyzed EV-associated molecules (ENPEP, TIMP1, CD36, MARCKS, DAB2, CXCL14, miR-181b-5p, miR-222-3p) using bioinformatics tools. We used GEPIA2; Human Protein Atlas (HPA) 24.0; bc-GenExMiner v5.1; UALCAN 2022; Kaplan-Meier plotter 2025; ENCORI database v2.0; Enrichr-KG web tool 2021; Cancer Hallmark Enrichment tool 2025; Tumor, Normal, and Metastatic (TNM) plot database 2025; MicroRNA Target Prediction Database 6.0; TargetScan 8.0; and STRING database 12.0. CD36, DAB2, and CXCL14 were significantly downregulated, while TIMP1 was upregulated in BC tissues ( < 0.05). CD36, CXCL14, and DAB2 were predominantly low in triple-negative and basal-like subtypes, whereas TIMP1 was higher in HER2+, ER+, and PR+ tumors ( < 0.01). These changes correlated with promoter methylation patterns. Higher TIMP1, DAB2, and CXCL14 levels were associated with improved overall survival ( < 0.05). miR-222-3p was downregulated and positively correlated with TIMP1 and DAB2, while miR-181b-5p was upregulated and negatively correlated with CXCL14. TNM analysis confirmed these expression changes. Functional enrichment linked these molecules to key cancer hallmarks, including proliferation and angiogenesis. CD36, DAB2, CXCL14, TIMP1, miR-222-3p, and miR-181b-5p may serve as biomarkers for BC pathogenesis and potential therapeutic targets. Further studies are needed to validate these findings. - Source: PubMed
Publication date: 2025/06/19
Ayan DurmusBozkurt Polat Serife BuketOzmen EsmaGul Mehmet Ali - The number of mummies (MUM) in pigs is a major factor affecting sow reproductive performance. Reducing the incidence of MUM can effectively improve sow utilization efficiency. However, the complex mechanisms by which the host genome, gut microbiome, and metabolome interact to influence sow MUM remain unclear. Based on the current research landscape, this study systematically reveals the regulatory mechanisms of the host genome-gut microbiome-metabolome interaction network on sow MUM. By conducting a multi-omics analysis on the intestinal contents of Yorkshire sows during late gestation across different parities, we constructed a dynamic atlas of the gut microbiota and identified 385 core microbial taxa. Through multi-model MWAS and meta-analysis, we screened six key microbial taxa significantly associated with MUM, including , , , , , and . An mGWAS analysis further identified as regulated by host genetics, as well as candidate genes such as , , and , and important SNP loci such as and . The study found that the abundance of Proteobacteria in the sow's gut increased progressively from the first parity, providing a theoretical basis for pathogen suppression mechanisms. By integrating fecal metabolomics data, we constructed a four-dimensional regulatory network of host gene-gut microbiota-metabolite-host phenotype. This study innovatively combines quantitative genetics with multi-omics approaches, not only providing a theoretical foundation for understanding host-microbiota interaction mechanisms but also offering critical scientific guidance for reducing sow MUM incidence and improving reproductive efficiency. - Source: PubMed
Publication date: 2025/04/30
Wang MingyuZhang LinLiu ZheGuo AoYang GongsheYu Taiyong