Ask about this productRelated genes to: EFNA2 antibody
- Gene:
- EFNA2 NIH gene
- Name:
- ephrin A2
- Previous symbol:
- EPLG6
- Synonyms:
- ELF-1, LERK6
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-10
- Date modifiied:
- 2016-10-05
Related products to: EFNA2 antibody
Related articles to: EFNA2 antibody
- Prostate adenocarcinoma (PRAD) has substantial recurrence after primary treatment, and reliable prediction is clinically needed. We integrated clinical, genomic, and transcriptomic data to identify recurrence-associated genes, characterize their tumor microenvironmental context, and develop a prognostic model. - Source: PubMed
Publication date: 2026/03/14
Ma YuanLin GaotengWang KeruoLiu ZihaoShao YuanYu WenyueZhao XiaoyiYu DanZhan FangfangWang XinghangDuan ShidaDuan KeFei - Uveal melanoma (UVM) is a rare cancer that represents the second most common melanoma (after the cutaneous) and the most common primary intraocular malignancy in adults. Despite recent advances in the understanding of UVM pathogenesis, its prognosis remains unchanged, with half of patients dying because of liver metastasis. Erythropoietin-producing human hepatocellular receptors (EPHs) constitute the largest known family of tyrosine receptors, and, along with their ligands, EFNs, regulate key physiological processes and are implicated in cancer pathogenesis. In this study, we used open-access web bioinformatics platforms to explore and analyze big datasets provided by The Cancer Genome Atlas (TCGA) UVM cohort of patients. We profiled the genomic alterations present in a subset of UVM patients, highlighting a likely pathogenic deep deletion of . Survival analysis showed that overexpression levels of , , , , and are significantly associated with poor overall survival. Additionally, high expression levels of , , , , , , and correlate with reduced progression-free interval and disease-free survival. Finally, we identified the EPHs (, , , and ) and EFNs (, , , and ) that are significantly overexpressed in the aggressive epithelioid histological subtype and revealed that the majority of EPHs/EFNs are overexpressed in metastatic disease. In conclusion, our results highlight that a subset of EPHs and EFNs may be associated with worse clinical outcomes (, , , , , , and ), and an aggressive histological subtype (, , , , , , , and ). The potential correlation of these genes with clinicopathological parameters of UVM need to be evaluated and validated with bioinformatic and experimental approaches in well-characterized cohorts of UVM patients. - Source: PubMed
Publication date: 2025/12/31
Mandrakis GeorgiosFlessa Christina-MariaKeratsa PanoraiaZaravinos ApostolosTheocharis StamatiosSykaras Alexandros G - Chronic Obstructive Pulmonary Disease (COPD) is a complex and heterogeneous disease. Emphysema-predominant and non-emphysema predominant COPD are two major disease subtypes capturing important aspects of COPD heterogeneity. Molecular differences between these COPD subtypes are unknown. - Source: PubMed
Publication date: 2025/06/12
Zhang Yu-HangCastaldi Peter JBowler Russell PPratte Katherine AKinney Gregory LYoung Kendra ARijhwani HeenaLutz Sharon MHersh Craig PCho Michael HMorrow Jarrett DSilverman Edwin K - During the formation of the auditory system in mammals, spiral ganglion neurons (SGNs) form ribbon-type synapses with hair cells in the cochlea to establish the first "sensorineural" component of sound transduction. Ahead of synapse formation in the cochlea, the SGNs undergo migration and extension with developing Schwann and otic mesenchyme cells to form radial bundles, fasciculated groups of nerve fibers found between the SGN somata and hair cells. Thus far, reports have shown that Eph/Ephrin signaling is important for the formation of radial bundles. Here, we show that EPHRIN-A1 and -A2 are broadly expressed in the developing cochlea during periods of SGN peripheral axon extension. Confronting spiral ganglion explants with either EPHRIN-A1- or -A2-Fc in vitro promoted neurite extension and reduced fasciculation. EPHRIN-A1- or -A2-Fc treatments also led to increased levels of phosphorylated ERBB2 immunoreactivity in Schwann cells, suggesting a role for developing glia. Loss of Efna1 and Efna2 in mouse models led to approximately a 25 % reduction in SGN peripheral axon extension, an effect that was maintained into adulthood. Overall, the data presented here indicate that EPHRIN-A1 and -A2 are important for normal patterns of cochlear innervation in that they serve as positive growth factors for developing radial bundles, possibly by stimulating Schwann cells. - Source: PubMed
Publication date: 2025/05/07
Gurjar MansaAmanipour RezaBalendran VinodhGhimire SatishDemirhan Mehmet AlpFlynn Alexander JSeernaum NidheeRose Kevin PSong YangHertzano RonnaCoate Thomas M - Due to the highly heterogeneous and immunosuppressed tumor microenvironment (TME), pancreatic adenocarcinoma (PAAD) has limited therapeutic options and an abysmal prognosis. Ephrin A 1-5 (EFNA1-5) have been shown to regulate tumorigenesis and metastasis in various cancers, but its role in PAAD remains unclear. - Source: PubMed
Publication date: 2025/04/02
Li Yu-ChaoZhang LuWang Yi-TingHu HaoZhang Ze-YuNie Qian-QianZuo Chang-Jing