Ask about this productRelated genes to: DTYMK antibody
- Gene:
- DTYMK NIH gene
- Name:
- deoxythymidylate kinase
- Previous symbol:
- -
- Synonyms:
- CDC8, TYMK, TMPK
- Chromosome:
- 2q37.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-12
- Date modifiied:
- 2016-10-05
Related products to: DTYMK antibody
Related articles to: DTYMK antibody
- Manganese metabolism may be involved in the malignant progression of lung adenocarcinoma (LUAD). Clarifying the roles of manganese metabolism-related genes (MMRGs) in LUAD may provide potential therapeutic targets for LUAD treatment. Mendelian randomization analysis and machine learning methods were applied to analyze transcriptome data for screening prognosis-related genes in LUAD. Subsequently, a risk model was constructed and a nomogram was plotted. Meanwhile, a series of analyses were carried out focusing on the immune microenvironment, drug sensitivity, and the single-cell level. Finally, the expression of relevant proteins was further verified by combining RT-qPCR and Western Blot. We have screened out six risk genes for LUAD: TXNRD1, CDKN3, BTG2, SELENBP1, DTYMK, and CHEK1. Subsequently, a risk model was constructed, which effectively predicts the survival of LUAD patients. Gene Set Enrichment Analysis (GSEA) revealed that these six genes may be involved in the regulation of the cell cycle in LUAD. In addition, they may modulate the tumor immune microenvironment and induce resistance to chemotherapeutic drugs. RT-qPCR and Western Blot confirmed low BTG2 and SELENBP1 and high CDKN3, CHEK1, DTYMK, and TXNRD1 expression in LUAD tissues and cell lines. Our study indicates that TXNRD1, CDKN3, BTG2, SELENBP1, DTYMK, and CHEK1 may be important biomarkers for the prognosis of LUAD, providing potential approaches for prognostic evaluation and medication strategies in LUAD. - Source: PubMed
Publication date: 2026/07/20
Zha JianhuaLiu XiaomingGao ShansongHe JiasiZhang Zhi - The HAUS family proteins (HAUS1-HAUS8) are essential for mitotic spindle microtubule nucleation. Although HAUS dysregulation has been linked to tumor progression, whether these oncogenic functions are conserved or tissue-specific remains unclear. Therefore, a pan-cancer analysis is needed to identify universal HAUS drivers and context-dependent members for precision oncology. - Source: PubMed
Publication date: 2026/05/22
Liu YanliLiu KangDing YangLi XiaodongShi XuanxuanZhang JunruiZhang XiangyuePeng WeiyaoDeng JingyiChen Jingqi - Dihydromyricetin (DHM), a natural dihydroflavonol, exhibits diverse pharmacological properties, including anti-inflammatory, antioxidant, and anti-tumor effects. However, its potential mechanism of action in the individualized therapy of hepatocellular carcinoma (HCC) remains unclear. - Source: PubMed
Publication date: 2025/12/02
Xu YangGu ChaoLi WeiLan FeiMao JingkunTan XiaoLi Pengfei - PURPOSE: Hepatocellular carcinoma (HCC) is recognized as one of the most aggressive cancers worldwide. This study aims to discover novel biomarkers that can effectively stratify patients at high risk for HCC and facilitate personalized management. METHODS: Differentially expressed genes analysis was conducted to identify marker genes associated with HCC based on transcriptomic profiles from the TCGA-LIHC database. And then, we utilized the weighted correlation network analysis (WGCNA) to explore the correlation between various gene expression clustering modules based on the the identified differentially expressed genes above and clinical phenotypes. Subsequently, we integrated 10 machine learning algorithms into 117 combinations to establish the optimal model for predicting survival in HCC patients. Then, immune landscape was evaluated. Additionally, single-cell RNA sequencing analysis revealed the expression patterns of genes involved in model at single-cell resolution. Furthermore, the role of DTYMK was examined in vitro in two liver cancer cell lines. RESULTS: Forty-eight G2/M checkpoint-related genes were identified as marker genes for HCC. Among these, STMN1, DTYMK, EZH2, PBK, and UCK2 were incorporated into a prognostic model (G2/MR), which demonstrated robust and reliable performance in predicting the survival rates of HCC patients. Individuals with high G2/MR scores exhibited shorter survival and higher regulatory T cells infiltration compared to those with low G2/MR scores. Silencing DTYMK arrested cell cycle and inhibited proliferation, migration, invasion, and colony formation in Huh-7 and PLC/PRF/5 cells. CONCLUSION: Our study developed a five-gene risk score model that may serve as a valuable tool for prognostic assessment and personalized HCC management. - Source: PubMed
Publication date: 2025/11/13
Guo KunxiongLin YucongLin Wanting - Microphthalmia-associated transcription factor (MITF) regulates melanocyte differentiation, proliferation, and survival, intersecting with oncogenic and tumor-suppressive pathways. However, its prognostic significance in uveal melanoma (UM) remains unexplored in large cohorts. This study examines MITF's prognostic value and its correlation with key molecular markers-BAP1, preferentially expressed antigen in melanoma (PRAME), deoxythymidylate kinase (dTYMK), and poly(ADP-ribose) polymerase 1 (PARP1). - Source: PubMed
Pilch JustynaKrzyzinski MateuszMarkiewicz AnnaBiecek PrzemyslawMazur Antonina JRomanowska-Dixon BozenaHoang Mai PDonizy Piotr