Ask about this productRelated genes to: DPP3 antibody
- Gene:
- DPP3 NIH gene
- Name:
- dipeptidyl peptidase 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-25
- Date modifiied:
- 2016-02-05
Related products to: DPP3 antibody
Related articles to: DPP3 antibody
- Bone is a unique specialized connective tissue comprising inorganic and organic components which continuously undergoes remodeling through the activity of anabolic and catabolic pathways. Peptidases are enzymes cleaving peptide bonds in a broad range of substrates and hence involved in many pathophysiological mechanisms. We previously reported that lack of Dpp3 in the mouse model results in bone loss and here we aimed to establish whether it also affected bone matrix composition. - Source: PubMed
Publication date: 2026/08/03
Bevacqua EmiliaVioli FedericaGranata ValentinaBedin FabioSantillo MariarosariaMenale CiroMazziotti GherardoSobacchi Cristina - Sepsis and septic shock are associated with high mortality rates and constitute the primary cause of death in intensive care units worldwide. Activation of the circulating renin-angiotensin-aldosterone system (RAAS) is an early event, and elements of the RAAS, including renin, Angiotensinogen, and ACE2, may be predictive of worse outcomes and higher mortality that reflect a failure to increase the circulating levels of the vasopressor Ang II. Emerging evidence suggests that dipeptidyl peptidase III (DPP3) is involved in the metabolism of Ang II, and higher DPP3 in septic shock may contribute to lower Ang II tone. The current review considers the role of a dysfunctional RAAS to maintain blood pressure and adequate tissue perfusion in septic shock. - Source: PubMed
Publication date: 2026/01/13
Schaich Christopher LKhanna Ashish KChappell Mark C - Photodynamic therapy (PDT) faces significant challenges in treating solid tumors due to the hypoxic tumor microenvironment and high degree of tumor heterogeneity. To address this issue, this study employed a strategy of acceptor planarization coupled with tunable terminal aryl modulation to design and synthesize a series of type I photosensitizers (DPP-1-DPP-3) with systematically tuned push-pull character and electronic structures. Among them, DPP-3 exhibits outstanding near-infrared emission and hypoxia-tolerant reactive oxygen species generation. Building on this core module, we integrated a biomarker-responsive unit into DPP-3 to construct an intelligent theranostic probe, DPP-CE. This probe retains high photodynamic activity both before and after activation, ensuring reliable therapeutic efficacy independent of local activation efficiency, while its near-infrared fluorescence signal is specifically activated only within the tumor microenvironment, enabling imaging-guided precise treatment. Both in vitro and in vivo experiments demonstrate that DPP-CE allows high-contrast fluorescence imaging of tumors and effectively inhibits tumor growth under both normoxic and hypoxic conditions, while showing good biosafety. This work not only provides a new strategy for developing high-performance type I photosensitizers, but also offers a modular approach that integrates a therapeutic core with a biomarker-responsive unit, paving the way toward programmable theranostic platforms adaptable to tumor heterogeneity. - Source: PubMed
Publication date: 2026/07/28
Dong XuemeiZeng LinganLiu YunlongWang MingmingWen FanZhang YujunYan DingyuanTang Ben ZhongYu XinghuaSun Fei - Circulating Dipeptidyl Peptidase 3 (DPP3) hydrolyses dipeptides from the amino terminus of its substrates and excess levels represent a target for the treatment of cardiogenic shock. Known substrates include Angiotensin II (Ang II), but there might be more. Adrenomedullin (ADM) is a 52-mer peptide regulating vascular tone and integrity, which also is a therapeutic target for the treatment of shock. The pathways leading to shock involving DPP3 and ADM have been considered independent so far. Here, we assessed the influence of ADM on the activity of DPP3 using an established assay. ADM inhibited DPP3 activity at a similar IC50 concentration (6.5 µM) as the cognate substrate Ang II (6.6 µM). As opposed to Ang II, ADM was barely cleaved by DPP3 . Stepwise C-terminal truncation of ADM essentially did not change its inhibitory effect. Inhibition of DPP3 activity by ADM was reversed by an anti-N-terminal ADM antibody. - Source: PubMed
Publication date: 2026/07/13
Nissen RuqayyahYourdkhani AminHollerbach Marie-LouiseSeewald KatjaSantos KarineStruck JoachimBergmann Andreas - Effective host defense requires coordinated regulation of immune activation, metabolism, and redox balance, yet how these processes are integrated remains unclear. Here, we identify dipeptidyl peptidase 3 (Dpp3) as a regulator of immune activation thresholds during bacterial infection. Dpp3-/- mice display enhanced resistance to Klebsiella pneumoniae, with early divergence in bacterial burden, improved survival, preserved tissue architecture, and reduced systemic inflammation. Adoptive transfer experiments demonstrate that Dpp3-deficient immune cells are sufficient to confer protection, indicating a cell-intrinsic effect. Mechanistically, Dpp3 deficiency impairs inducible Nrf2 stabilization, resulting in amplified ROS accumulation and enhanced NF-κB-associated responses. Integrated metabolomic, bioenergetic, and proteomic analyses reveal coordinated mitochondrial remodeling and activation of inflammatory signaling networks, consistent with a metabolically primed immune state. Collectively, these findings establish Dpp3 as a systems-level regulator integrating redox control and immunometabolism to calibrate antimicrobial responses during infection. - Source: PubMed
Publication date: 2026/07/06
Facoetti AmandaLambroia LucaFontana ElenaNicchiotti FedericoSchiavone Maria LuciaStrina DarioViganò RaffaelloBrambilla FrancescaMangioni DavideScaramuzza SamanthaMallia SaraBonanomi MarcellaFarini AndreaMeregalli MirellaMostosi DeboraRocca GiuseppeMenale CiroGarlanda CeciliaMuscatello AntonioBandera AlessandraGaglio DanielaSobacchi CristinaTorrente YvanMauri PierluigiDi Silvestre DarioPeano CleliaGranucci FrancescaMarrella VeronicaCassani Barbara