Ask about this productRelated genes to: DPP3 antibody
- Gene:
- DPP3 NIH gene
- Name:
- dipeptidyl peptidase 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-25
- Date modifiied:
- 2016-02-05
Related products to: DPP3 antibody
Related articles to: DPP3 antibody
- - Source: PubMed
Publication date: 2026/03/25
van Lier DirkSantos KarineHartmann OliverKox MatthijsPickkers Peter - Dipeptidylpeptidase 3 (DPP3) is a ubiquitous intracellular peptidase recently identified in the circulation (cDPP3) as a biomarker and therapeutic target in circulatory failure. The source and mechanism of DPP3 release remain unclear. Based on increased DPP3 expression in the bone marrow compartment under stress conditions, we aimed to assess bone marrow's contribution to DPP3 release. WT bone marrow was transplanted into irradiated DPP3-knockout (KO) mice, generating KO mice, which recovered 44% of baseline cDPP3 activity. In stressed KO mice, cDPP3 increase was comparable to stressed WT mice. DPP3 injection in WT mice induced cardiac neutrophil infiltration. Extracellular vesicles from plasma and bone marrow carried only a minimal fraction of DPP3, indicating mainly soluble release. These results reveal bone marrow-derived cells as a main driver of cDPP3 release under stress and provide a foundation to optimize its use as a biomarker and therapeutic target. - Source: PubMed
Publication date: 2026/02/20
Assad NomaNordin HugoNguyen AlexisOddos ClaireMarguerit GwendolynDelgado LalouSchiltz IsabellePicod AdrienZalc MaximeBeurton AntoineTanguy MarionRautou Pierre-EmmanuelSadoune MalhaPolidano EvelyneLaunay Jean-MarieSantos KarineVodovar NicolasOuattara AlexandreLogeart DamienCalmont AmélieMebazaa AlexandreAzibani Feriel - - Source: PubMed
Publication date: 2026/03/03
Picod AdrienBoussier JeremyTubiana SarahLouis GuillaumeLefevre Laurent MartinTiteca-Beauport DimitriCombe Béatrice LaBesset SébastienBadie JulioChevrel GuillaumeChudeau NicolasBarbar SaberVinsonneau ChristopheForel Jean-MarieThevenin DidierLacave GuillaumeNseir SaadOziel JohannaMayaux JulienKlouche KadaReignier JeanRicard Jean-DamienQuenot Jean-PierreMebazaa AlexandreAzibani FerielDreyfuss DidierGaudry StéphaneChaïbi Khalil - - Source: PubMed
Publication date: 2026/02/06
Teixeira J PedroSchaich Christopher LTen Lohuis Caitlin CNielsen Nathan DChen PeterGinde Adit AHager David NKhan AkramMerck Lisa HSafdar BasmahSturek Jeffrey Mde Wit MarjoleinHarkins Michelle SSelf Wesley HCollins Sean PBusse Laurence W - The rapid evolution of cardiovascular (CV) research demands innovative strategies to enhance risk stratification, diagnosis, and management. While traditional biomarkers, such as natriuretic peptides and troponins, remain essential, they often fall short due to suboptimal sensitivity and specificity, particularly in complex or early-stage cases. Emerging biomarkers are central to advancing personalized medicine by enabling earlier, more accurate detection of CV diseases and enhancing predictive algorithms, including those powered by artificial intelligence and machine learning. Among these novel biomarkers, dipeptidyl peptidase 3 (DPP3) has recently garnered attention as a highly specific indicator of cardiogenic shock, offering both prognostic value and therapeutic target potential. Released during cellular stress, circulating DPP3 (cDPP3) plays a mechanistic role in myocardial depression and blood pressure regulation, positioning it as a compelling candidate for inclusion in multi-marker panels. Its integration into predictive models could further refine therapeutic decision-making and patient stratification in acute cardiac care. This editorial discusses the clinical value of incorporating cDPP3 into CV biomarker research and advocates its inclusion in next-generation predictive algorithms and real-time decision-support tools. Continued exploration of such biomarkers may enable tailored interventions and improve outcomes in complex CV cases. - Source: PubMed
Ramoni DavideLiberale LucaCarbone FedericoMontecucco Fabrizio