Ask about this productRelated genes to: CPA1 antibody
- Gene:
- CPA1 NIH gene
- Name:
- carboxypeptidase A1
- Previous symbol:
- CPA
- Synonyms:
- -
- Chromosome:
- 7q32.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: CPA1 antibody
Related articles to: CPA1 antibody
- Post-endoscopic retrograde cholangiopancreatography (post-ERCP) pancreatitis (PEP) is the most severe adverse event associated with ERCP. Although numerous studies have identified risk factors for PEP, the role of genetic background in its development remains unexplored. The present study investigated the association between pancreatitis-related gene variants (PRG-variants) and PEP. - Source: PubMed
Publication date: 2026/04/27
Kabemura DaishiFujisawa ToshioSuzuki MitsuyoshiTomishima KoIshii ShigetoIkoma IppeiJimbo YasuhisaIkemura MuneoOta HirotoUshio MakoFukuma TaitoTakahashi ShoTakasaki YusukeNamima DaisukeIto KoichiShimizu ToshiakiIsayama Hiroyuki - Hereditary chronic pancreatitis (CP) is associated with elevated risk of pancreatic ductal adenocarcinoma (PDAC), but the specific contributing genes and their associated risk magnitudes remain incompletely defined. We aimed to investigate whether pathogenic germline variants (PGVs) in all 11 known CP-associated genes (CASR, CEL, CFTR, CLDN2, CPA1, CPB1, CTRC, PNLIP, PRSS1, SPINK1, TRPV6) predispose to PDAC and to quantify their risk estimates. - Source: PubMed
Publication date: 2026/04/20
Antwi Samuel ORabe Kari GCarlson Erin ESicotte HuguesBamlet William RMills Krystal CKonikoff Tom McWilliams Robert ROberg Ann LMajumder Shounak
- Source: PubMed
- Mast cells originate from mammalian myeloid hematopoiesis and exert a crucial role in inflammation and allergies. In recent years, studies have reported that carboxypeptidase A5 (cpa5) can serve as a marker for zebrafish mast cells. However, the absence of systematic experimental validation limited understanding of the origin, molecular characteristics, and function of mast cells. To address this gap, we initially confirmed zebrafish mast cell like cells in hematopoietic and peripheral tissues via staining and cytomorphological identification. Subsequently, spatiotemporal analysis and Tg(cpa5:GFP) sorting showed cpa5 mainly in mature neutrophils, rarely in mast cell like cells. Finally, gene knockout experiments revealed genetic compensation between cpa1 and cpa5 within the same gene family, and we further generated cpa1cpa5 double mutant zebrafish. Experiment showed that in cpa1cpa5, the number of neutrophils was reduced while their functional properties remained intact; the number of mast cell like cells increased but their functions were impaired. This study revises the current understanding of cpa5 as a specific mast cell marker, explores its role in neutrophils and mast cells development, and thereby offers novel insights into zebrafish immune system. - Source: PubMed
Publication date: 2026/02/28
Wu ZiyanHu YunjiaXu SongenHuang ZhibinZhang WenqingLiu Wei - The potential risks of TiCT (MXene) nanomaterials to the ecological environment and human health have drawn increasing attention due to their widespread applications in the fields of biomedicine and environmental remediation. Although the aquatic ecotoxicity of TiCT has been reported, little is known about how TiCT disrupts the physiological processes that regulate growth and development in zooplankton. This study investigated the toxic effects and mechanisms of TiCT exposure on the growth and development of through gene expression and gut microbiome analyses. Results show that TiCT exposure significantly reduced moulting frequency, body length, body width, and absolute growth rate in . Exposure to TiCT led to a significant decrease in the expression of growth and development-related genes (, , , and ) in . Microbiome analysis revealed that exposure to TiCT resulted in a decrease in Proteobacteria and an increase in Bacteroidota in the microbial community of . Meanwhile, TiCT induced reduced abundances of and , as well as increased abundances of and . These microbial functions primarily contribute to energy acquisition and metabolism. This study indicated that TiCT can inhibit the growth and development of by inhibiting the expression of growth and development-related genes and inducing intestinal microbial community dysbiosis. This study provides new insights into understanding the mechanisms of TiCT toxicity on the growth and development of zooplankton in aquatic ecosystems. - Source: PubMed
Publication date: 2026/02/09
Xiang QianqianWu YanpingLi YongfangLi ShaoxiangChang Xuexiu