Ask about this productRelated genes to: CORO1A antibody
- Gene:
- CORO1A NIH gene
- Name:
- coronin 1A
- Previous symbol:
- -
- Synonyms:
- HCORO1, p57, coronin-1
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-19
- Date modifiied:
- 2019-04-23
Related products to: CORO1A antibody
Related articles to: CORO1A antibody
- Emerging evidence implicates intestinal barrier dysfunction and translocation of microbial factors as key drivers of post-myocardial infarction inflammation and cardiac remodeling, yet therapeutic strategies targeting the gut-heart axis remain underdeveloped. Here we demonstrate that ALY688, an adiponectin receptor agonist peptide, confers robust cardioprotection in rat myocardial ischemia-reperfusion (IR) injury through coordinated immunoregulatory programs in cardiac and intestinal tissues. ALY688 administration during ischemia or at reperfusion and subsequently daily for 28 days significantly preserved cardiac function with improved ejection fraction and fractional shortening, reduced infarct size, and decreased cardiac troponin-I levels. Mechanistic investigation revealed tissue-specific immune reprogramming: in the myocardium, ALY688 directly activated macrophages to secrete TGFβ1, which promoted regulatory T cell (Treg) differentiation from naïve CD4 + T cells as validated in macrophage-T cell co-culture systems. This macrophage-to-Treg axis suppressed inflammasome activation and IL-1β/IL-23/IL-6 signaling while enhancing anti-inflammatory macrophage polarization. Simultaneously, ALY688 strengthened intestinal barrier integrity through activation of the RORγt/IL-17 pathway, upregulating tight junction proteins (Claudin-1, ZO-1) and mucins (MUC19, MUC22), thereby limiting systemic spillover of bacterial endotoxin (LPS) and other microbial metabolites. Multi-omics profiling supported this dual-compartment mechanism: proteomics revealed modulation of immune regulatory (CAPG, CORO1A, MCAM) and cardioprotective (clusterin, NPPA) proteins, while metabolomics demonstrated attenuation by ALY688 of post-IR elevations in pathogenic gut-derived metabolites (anthranilic acid, imidazole propionate, linoleic acid derivatives). This study establishes adiponectin receptor activation as a multi-organ immunometabolic intervention that simultaneously resolves cardiac inflammation while protecting intestinal barrier function. These findings provide mechanistic insight for therapeutic strategies that target the gut-heart axis to address a major remaining unmet clinical need in ischemic heart disease. - Source: PubMed
Publication date: 2026/07/28
Tang JialingSung Hye KyoungLei YubinTeerawongsuwan SasipatRungsiwiwut RuttachukWannaiampikul SivapornChen JiaruiRidany IbrahimRichard VincentBorchers ChristophKim YoojungCho Ssang-GooCoquant GaranceCorr Sinéad CWu JunLi Ren-KeWang ChaoAbdul-Sater Ali ASweeney Gary - Liver fibrosis, a wound-healing response to chronic liver injury characterized by excessive extracellular matrix (ECM) accumulation, represents a major global health burden with no approved anti-fibrotic therapies. Pien Tze Huang (PZH), an officially approved traditional Chinese medicine (NMPA Drug Approval No. Z35020243), has demonstrated hepatoprotective effects, yet its epigenetic mechanisms in fibrosis treatment remain unexplored. : We performed the first integrated methylome-transcriptome-proteome analysis to investigate PZH's anti-fibrotic mechanisms in a CCl-induced mouse model using reduced representation bisulfite sequencing (RRBS), RNA-seq, and TMT-labeled LC-MS/MS. : We identified 10,974 differentially methylated loci (DMLs) and 773 differentially expressed genes (DEGs) modulated by PZH treatment. Integration analysis revealed ANXA3 and CORO1A as candidate therapeutic targets exhibiting significant inverse methylation-expression correlations validated at both transcriptomic and proteomic levels. Notably, PZH treatment modulated the CRLF-CLCF1 cytokine complex and the EGR-3 transcription factor network (42/44 genes enriched), suggesting broad transcriptional reprogramming in fibrotic liver. Protein-protein interaction (PPI) analysis highlighted key gene pairs such as , , and , implicating PZH in epigenetic maintenance, transcription factor regulation, and ECM remodeling. These findings suggest mechanistic insights into PZH's multi-target anti-fibrotic effects and offer a rationale for developing potential therapeutic targets for liver fibrosis. - Source: PubMed
Publication date: 2026/07/10
Wu HaoGao LonghuiZhao XianglongLi XiangyiLin YunxiaoChen LuanLi LixingShen LuBao WeiZhu JinhangHuai CongChen ZhiliangZhuang YichaoQin Shengying - Diabetic nephropathy (DN) is characterised by progressive renal tubular epithelial cell injury, yet underlying molecular mechanisms remain incompletely understood. - Source: PubMed
Meng ShenghaoXu XitongChen HongruZhang ZhigangWu HuijuanQi Chenyang - Osteoarthritis (OA) is increasingly understood as a condition influenced by the diversity of chondrocytes and immune system dysfunction; however, the specific molecular elements connecting distinct chondrocyte populations to the immune environment remain inadequately explored. The protein CORO1A, associated with the cytoskeleton and implicated in immune regulation, has not been thoroughly investigated in the context of OA or through single-cell analysis. - Source: PubMed
Publication date: 2026/06/11
Liang QiujianNing ChaoGao ShiyaoLiu DongxinZhao JinminHuang LinkeHou JunTan Zhen - Macrophages are central regulators of liver immunity and fibrosis; Recent single-cell studies have characterized macrophage heterogeneity in cirrhosis; however, how regulated cell death programs shape their functional transitions across disease progression in human liver remains poorly defined. - Source: PubMed
Publication date: 2026/06/25
Zheng KepuDai LeiyangWen YanghuiJiang HaitaoGao YangRen FengTang YuHuang XiangRan JianghuaChen Yunjie