Ask about this productRelated genes to: CDK2 antibody
- Gene:
- CDK2 NIH gene
- Name:
- cyclin dependent kinase 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-28
- Date modifiied:
- 2016-06-10
Related products to: CDK2 antibody
Related articles to: CDK2 antibody
- Cuproptosis, a newly discovered form of copper-driven regulated cell death, has been shown to be closely related to ovarian function. However, whether the oocyte dysfunction, decreased ovulation efficiency, and cumulus cell aging caused by copper overload or imbalance are associated with regulatory pathways related to cuproptosis remains unclear. In this study, the expression profiles of genes related to cuproptosis in cumulus cells were comprehensively analyzed through transcriptome sequencing and metabolome analysis, and key genes and pathways that affect oocyte maturation were identified in response to elesclomol and CuSO treatment. Transcriptome analysis of cumulus cells revealed the differential expression of genes involved in key biological processes, such as cellular senescence (AKT3, MORC3, RBL1, etc.), gap junctions (GJA1, GNAI1, GJB3, etc.), steroid biosynthesis (FDX1, HSD17B7, CYP1A1, etc.), and cell cycle regulation (CDK2, CCNB2, MAPK7, etc.). Metabolomic analysis revealed significant changes in the levels of malic acid, PS (18:3(10,12,15)-OH(9)/14:0), and PA (21:0/LTE4), among other compounds. Subsequent Smart-seq analysis of oocytes revealed that after cuproptosis was induced in cumulus cells, oocyte maturation was disrupted, which affected genes associated with cellular senescence (TGFB2, SIRT1, CHEK2, etc.), oocyte meiosis (FBXO5, CCNB3, PLK1, etc.), and DNA methylation (PPM1D, DNMT3B, KMT2A, etc.). These findings provide deeper theoretical support for the key genes and biological processes involved in cumulus cell regulation and oocyte maturation, further clarifying the regulatory mechanisms of cuproptosis in the field of reproduction. - Source: PubMed
Publication date: 2026/05/05
Xu HongTian TianXu DanDu XiaoxueSu RuiLiang JinghongLiu YingZhang YuqingLiu ChangLiang ShuangLi QingyingDing DeliHan YongshengZhai BoLi JidongChen ChengzhenZhang JiabaoJiang HaoYuan Bao - Aneuploidy is a cancer hallmark that causes resistance to anticancer drugs and promotes aggressive tumors. Thus, aneuploidy is a consequential feature of human malignancy. This review addresses how cyclin dependent kinase 2 (CDK2) inhibition targets a broad array of aneuploid cancers for proapoptotic death by engaging a death program called anaphase catastrophe. This program eliminates aneuploid cancers while sparing non-aneuploid epithelial cells, thereby providing a favorable therapeutic window. Despite CDK2 inhibition, a residual population of polyploid cancer cells persists in both in vitro and in vivo settings. This polyploid cancer cell population is resistant to apoptosis conferred by CDK2 inhibition of aneuploid cancers. This provides a basis for clinical drug resistance. The triggering apoptotic death of aneuploid cancers via CDK2 antagonism is compromised by the presence of this apoptosis-resistant population. To elucidate the nature of this polyploid population, these apoptotic-resistant cells were isolated and were found enriched for expressed cyclin dependent kinase 1 (CDK1) and Kinesin superfamily proteins (KIFs). Intriguingly, combining CDK2 inhibition with antagonists for CDK1 or KIF species markedly promoted anti-cancer effects in aneuploid cancers. This clinically-tractable combined regimen is hypothesized to expose aneuploid cancers to eradication after CDK2 antagonism. Future clinical trials should explore this possibility. - Source: PubMed
Publication date: 2026/05/07
Okpechi Samuel CChen ZiboTyutyunyk-Massey LiliyaAlfaro YairLiu XiDmitrovsky Ethan - Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide, highlighting the urgent need for novel therapeutic agents. In this study, a series of pyrimidine-based derivatives were designed and synthesized to evaluate their potential as anti-breast cancer agents. The compounds were screened for anti-proliferative activity against MDA-MB-231 breast cancer cells, and selected candidates were further assessed for CDK2 inhibitory potential. Among the synthesized compounds, 7b (IC₅₀ = 4.21 ± 0.62 μM) and 7d (IC₅₀ = 5.16 ± 0.71 μM) exhibited potent cytotoxicity and induced apoptosis, with 7d also demonstrating significant CDK2 inhibition. Computational studies, including molecular docking, molecular dynamics simulations, and binding energy analyses, revealed stable interactions within the CDK2 active site. Additionally, ADMET predictions indicated favorable pharmacokinetic and drug-like properties. Overall, these findings suggest that pyrimidine-based compounds, particularly 7b and 7d, possess promising anti-proliferative properties, with CDK2 inhibition contributing to their mechanism of action and supporting their potential as lead candidates for breast cancer therapy. - Source: PubMed
Publication date: 2026/05/03
Sutar Niteen RAlegaon Shankar GGharge ShankarRanade Shriram DKamble Praveen A - Lemmaphyllum drymoglossoides (Baker) Ching is a widely used folk herbal remedy that has been employed in cancer treatment. However, studies on the anti-colorectal properties and phytochemicals of L. drymoglossoides essential oil (EO) are currently lacking. - Source: PubMed
Publication date: 2026/05/04
Hu QiongRan YuanquanChen GuoXia WenweiYang LanlanLiu JunlinYang BingWu WenyuTang DongxinTian Minyi - Breast cancer is the leading cause of cancer mortality among women globally, and drug resistance complicates treatment. Garlic-derived organosulfur compounds exhibit anticancer potential, but their multi-target activity against key breast cancer biomarkers remains unclear. This study utilized AutoDock Vina for molecular docking, OpenBabel for post-docking energy minimization, and employs SWISS-ADME and PreADMET platforms for ADMET profiling to assess six garlic compounds (Z-ajoene, allyl-methyl trisulfide, diallyl disulfide, diallyl sulfide, diallyl trisulfide, and S-allyl-L-cysteine) against clinically relevant breast cancer targets. Z-ajoene showed strong binding to Bcl-2, Topoisomerase II, and CDK-2, while S-allyl-L-cysteine targets five biomarkers. All compounds complied with Lipinski's rule of five, indicating good oral bioavailability, and display favorable ADMET properties with no mutagenic or tumorigenic risks. Most compounds were predicted to inhibit P-glycoprotein, while only Z-ajoene showed potential inhibition of CYP2C9, suggesting possible drug-drug interactions. Despite moderate affinities, these compounds may serve as potential promising multi-target agents in breast cancer therapy. Our computational findings provide preliminary evidence that garlic-derived compounds warrant further in vitro and in vivo evaluation, particularly in the context of drug-resistant breast cancer. - Source: PubMed
Publication date: 2026/05/06
Siame CourageOfori BenedictPaemka Lily AdzoDanquah Kwabena Owusu