Ask about this productRelated genes to: CDCP1 antibody
- Gene:
- CDCP1 NIH gene
- Name:
- CUB domain containing protein 1
- Previous symbol:
- -
- Synonyms:
- CD318, SIMA135
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-02-24
- Date modifiied:
- 2016-10-05
Related products to: CDCP1 antibody
Related articles to: CDCP1 antibody
- Coronary artery disease (CAD) is a leading global cause of mortality, yet the predictive accuracy of conventional risk models is limited. Here, we integrate conventional risk factors, polygenic risk scores, and large-scale proteomics to develop a unified model for enhanced CAD risk prediction. - Source: PubMed
Publication date: 2026/06/15
Huang YuezhongChen XiaoliZhang HaoBai ZhanpeiShen YifanZheng DaishanFang LongyuSong HongziGao HebeiLu FanHuang Xiu-Feng - Cadmium (Cd) contamination limits plant growth and productivity. This study evaluated whether cold plasma (CP) seed treatment mitigates Cd stress in two wheat cultivars, Borlaug-16 (B-16) and Zincol-16 (Z-16). Seeds were exposed to CP for 1-4 min and grown under 50 ppm Cd. CP improved germination, with B-16 showing a 40% increase in germination percentage under CP1 and Z-16 a 90.47% increase in germination index under CdCP1 compared to the control. Growth and yield traits also improved; in B-16, grain yield increased by 45.19% (CdCP1) and biomass by 32.29% (CP1), while Z-16 showed an 83.07% increase in biomass (CP4) and a 66.94% increase in total chlorophyll (CdCP4). Oxidative damage declined, with malondialdehyde reduced by 7.79% (B-16, CP4) and 9.09% (Z-16, CP2), accompanied by increased activities of superoxide dismutase, catalase, peroxidase, and ascorbate peroxidase. Leaf Cd concentrations decreased by 38.73% in B-16 and 71.79% in Z-16 under CdCP1 relative to Cd-stressed plants. Overall, CP treatment was associated with reduced oxidative stress and improved physiological performance. These results indicate that CP is a practical approach to improve wheat performance under Cd-contaminated conditions. - Source: PubMed
Publication date: 2026/06/12
Aslam RimshaElahi MinhasAnas MuhammadTahir NimraFayad EmanIjaz FatimaBinjawhar Dalal NasserKhan Khalid AliErcişli SezaiQuraishi Umar Masood - Tuberculosis (TB) continues to be a major public health concern. Thus, identifying individuals at risk of progression to active disease is important for community health but remains difficult. To address this issue, we analysed plasma proteomic data from the UK Biobank to investigate host protein signatures associated with TB. The size of the prospective cohort (~ 500,000) combined with deep proteomic analysis (2,920 plasma proteins) allowed us to perform analysis on 42 individuals diagnosed with TB either before or after sampling, alongside matched controls with no history of TB. Using this approach, we identified significantly differentially expressed proteins (e.g. CDCP1, GAST) in individuals affected by TB, suggesting proteomics alternations that precede clinical onset and persist years after diagnosis. Functional annotation of significant proteins indicated involvement of immune and signalling pathways associated with chronic inflammatory responses and host defence mechanisms. These findings help advance the understanding of TB pathology and offer the potential for use of specific plasma proteins in the development of point of care risk assessment and diagnostic tools. - Source: PubMed
Publication date: 2026/06/06
Koziar NataliaWhetton Anthony DGeifman Nophar - This study aims to identify potential biomarkers for retinal detachment secondary to choroidal melanoma (CM). Mendelian randomisation (MR) analysis, immunohistochemistry, cell proliferation and migration assays, co-culture experiments involving human microglial cells (HMC3) and CM cells, and tube formation assay were employed to validate the role of IL-8 in retinal detachment secondary to choroidal melanoma. Mendelian randomisation analysis identified four inflammatory mediators causally linked to malignant melanoma progression: CDCP1 concentration ( = 0.017, OR = 0.999, 95% CI [0.998-1.000]), CSF-1 concentration ( = 0.020, OR = 1.002, 95% CI [1.000-1.003]), IL-10Rβ concentration ( = 0.004, OR = 0.999, 95% CI [0.998-1.000]), IL-17C concentration ( = 0.002, OR = 1.003, 95% CI [1.001-1.005]); Four inflammatory factors exhibited a causal relationship with retinal detachment progression: IL-15Rα concentration ( = 0.029, OR = 1.001, 95% CI [1.000-1.001]), IL-2Rβ concentration ( = 0.007, OR = 1.003, 95% CI [1.001-1.004]), IL-8 concentration ( = 0.045, OR = 1.002, 95% CI [1.000-1.004]), TSLP concentration ( = 0.028, OR = 1.002, 95% CI [1.000-1.004]). MR analysis indicated that genetically predicted IL-8 levels are associated with an increased risk of retinal detachment. IL-8 is highly expressed in CM tissues and promotes the proliferation of CM and HMC3 cells. It partially relieves the inhibitory effects mediated by the supernatant of HMC3 cells and promotes angiogenesis. IL-8 may be involved in CM-related inflammatory microenvironments and secondary exudative retinal detachment. It is a potential biomarker and provides a new target for targeted anti-inflammatory therapy and improved patient prognosis. - Source: PubMed
Publication date: 2026/05/28
Xing ZhenZhang XinranYu WeiLei YingqingWang GuiquLv Hongbin - Osteomyelitis is a challenging orthopedic condition characterized by bone inflammation, often resulting from infection. The roles of inflammatory cytokines (ICs) and metabolites in its pathogenesis are not fully understood. - Source: PubMed
Chen XingyuMo RuiqingYang SijieZhou PeilinQikai Hua