Ask about this productRelated genes to: CBWD1 antibody
- Gene:
- CBWD1 NIH gene
- Name:
- COBW domain containing 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 9p24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-26
- Date modifiied:
- 2015-08-27
Related products to: CBWD1 antibody
Related articles to: CBWD1 antibody
- Varicose veins (VV) are a common chronic venous disease that is influenced by multiple factors. It affects the quality of life of patients and imposes a huge economic burden on the healthcare system. This study aimed to use integrated analysis methods, including Mendelian randomization analysis, to identify potential pathogenic genes and drug targets for VV treatment. - Source: PubMed
Publication date: 2024/05/15
Cui YuHu MengtingZhou HeGuo JiaruiWang QijiaXu ZaihuaChen LiyunZhang WancongTang Shijie - Mitochondria play essential roles in tumorigenesis; however, little is known about the contribution of mitochondrial DNA (mtDNA) to esophageal squamous cell carcinoma (ESCC). Whole-genome sequencing (WGS) is by far the most efficient technology to fully characterize the molecular features of mtDNA; however, due to the high redundancy and heterogeneity of mtDNA in regular WGS data, methods for mtDNA analysis are far from satisfactory. - Source: PubMed
Publication date: 2024/04/02
Zhuang XuehanYe RuiZhou YongCheng Matthew YiboCui HeyangWang LonglongZhang ShuangpingWang ShubinCui YongpingZhang Weimin - Tumor mutational burden (TMB) has been reported to determine the response to immunotherapy, thus affecting the patient's prognosis in many cancers. However, it is unclear whether TMB or TMB-related signature could be used as prognostic indicators for ovarian cancer (OC), as its potential association with immune infiltration remains poorly understood. Therefore, this study aimed to develop a novel TMB-related risk model (TMBrisk) to predict the prognosis of OC patients on the basis of exploring TMB-related genes, and to explore the potential association between TMB/TMBrisk and immune infiltration. The mutational landscape, TMB scores, and correlations between TMB and clinical characteristics and immune infiltration were investigated in The Cancer Genome Atlas (TCGA)-OV cohort. Differentially expressed gene (DEG) analyses and weighted gene co-expression network analysis (WGCNA) were performed to derive TMB-related genes. TMBrisk was constructed by Cox regression and further validated in Gene Expression Omnibus (GEO) datasets. The mRNA and protein expression levels and biological functions of TMBrisk hub genes were verified through Gene Expression Profiling Interactive Analysis (GEPIA), GSCA Lite, the Human Protein Atlas (HPA) database, and RT-qPCR. TMBrisk-related biological phenotypes were analyzed in function enrichment and tumor immune infiltration signature. Potential therapeutic regimens were inferred utilizing the Genomics of Drug Sensitivity in Cancer (GDSC) database and connectivity map (CMap). According to our results, higher TMB was associated with better survival and higher CD8+ T cell, regulatory T cell, and NK cell infiltration. TMBrisk was developed based on CBWD1, ST7L, RFX5-AS1, C3orf38, LRFN1, LEMD1, and HMGB1. High TMBrisk was identified as a poor factor for prognosis in TCGA and GEO datasets; the high-TMBrisk group comprised more higher-grade (G2 and G3) and advanced clinical stage (stage III/IV) tumors. Meanwhile, higher TMBrisk was associated with an immunosuppressive phenotype, with less infiltration of a majority of immunocytes and less expression of several genes of the human leukocyte antigen (HLA) family. Moreover, a nomogram containing TMBrisk showed a strong predictive ability demonstrated by time-dependent ROC analysis. Overall, this novel TMB-related risk model (TMBrisk) could predict prognosis, evaluate immune infiltration, and discover new therapeutic regimens in OC, which is very promising in clinical promotion. - Source: PubMed
Publication date: 2022/08/08
Wang HaoyuLiu JingchunYang JiangWang ZhiZhang ZihuiPeng JiaxinWang YingHong Li - Icariin presents protective effect in several kidney diseases. However, the role of icariin in contrast-induced acute kidney injury (CIAKI) is still unclear. This study aimed to investigate the effect of icariin in CIAKI, as well as exploring the underlying mechanism from the aspect of interaction between protein-coding genes and non-coding RNAs. - Source: PubMed
Publication date: 2022/07/23
Lin YanZhu GaofengLi XiaoyongYu HuaxiaoLuo YuhangLin JiaqiongLi RenyuanHuang Zena - Pulmonary function (PF) progressively declines with aging. Forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) are predictors of morbidity of pulmonary and cardiovascular diseases and all-cause mortality. In addition, reduced PF is associated with elevated chronic low-grade systemic inflammation, glucose metabolism, body fatness, and low muscle strength. It may suggest pleiotropic genetic effects between PF with these age-related factors. - Source: PubMed
Publication date: 2022/02/18
Feitosa Mary FWojczynski Mary KAnema Jason ADaw E WarwickWang LihuaSantanasto Adam JNygaard MarianneProvince Michael A