Ask about this productRelated genes to: C2orf40 antibody
- Gene:
- ECRG4 NIH gene
- Name:
- ECRG4 augurin precursor
- Previous symbol:
- C2orf40
- Synonyms:
- augurin
- Chromosome:
- 2q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-07-31
- Date modifiied:
- 2019-04-18
Related products to: C2orf40 antibody
Related articles to: C2orf40 antibody
- Current treatments for Alzheimer's disease (AD) primarily focus on slowing disease progression, emphasizing the urgent need for a reliable diagnostic method for early-stage Alzheimer's (EAD). Our investigation, which is based on the finding that the secretory protein Esophageal Cancer Related Gene 4 (ECRG4) is elevated in the hippocampus of AD patients, led to the creation of a novel ELISA system for ECRG4 detection. We observed that ECRG4 peptides, particularly the fragment spanning amino acids 108-132, were elevated in the plasma of approximately 25% of patients with mild cognitive impairment (MCI) and 50% of those with AD, compared to individuals without dementia. RNA sequencing of plasma samples revealed decreased levels of carbohydrate sulfotransferase 3 () mRNA, which is mainly expressed in oligodendrocyte (OLG)-lineage cells, in ECRG4-positive patients. Functional analyses demonstrated that the ECRG4 (71-107) peptide induced cytotoxicity in oligodendrocytes in vitro and reduced the expression of the OLG marker galactocerebroside in the corpus callosum following intracerebral injection. Additionally, peptide injection resulted in extravascular IgG leakage and the accumulation of OLG precursor cells (OPCs), which are crucial for myelin regeneration, around the blood vessels. These phenomena were similarly observed in the hippocampi of patients with EAD. Collectively, these findings establish ECRG4 as a novel serum marker for AD and suggest its association with ECRG4-dependent OLG dysfunction. - Source: PubMed
Publication date: 2026/05/15
Zhang LifuIkeda NaokiTakeda ShujiOikawa NaotoMurayama ShigeoKoshimizu UichiYabe IchiroKondo Toru - Esophageal cancer-related gene-4 (ECRG4) is a hormone-like protein that acts as a tumor suppressor by inducing cell death through apoptosis and cell-cycle arrest. ECRG4 is expressed in various organs, including the brain, and it influences the viability and function of neural cells such as oligodendrocytes and microglia. However, the effects of ECRG4 on astrocytes, which are essential neural cells that play significant roles in maintaining brain homeostasis, remain unclear. In this study, we demonstrate that ECRG4, specifically the region encompassing amino acids 71-107 (ECRG4(71-107)), induces cell death in mouse primary astrocytes. The ECRG4(71-107)-induced astrocyte death is associated with lysosomal damage and is mediated by cathepsins, indicating a lysosome-dependent cell death mechanism. Notably, ECRG4(71-107) promotes the secretion of cathepsins into the extracellular space. The introduction of exogenous cathepsins into the medium induced astrocyte death, while the removal of cathepsins from the conditioned medium reduced the toxicity associated with ECRG4(71-107). These findings suggest that extracellular cathepsins mediate the toxicity of ECRG4(71-107) in astrocytes. Overall, this study reveals a novel mechanism of cell death induced by ECRG4 in astrocytes and suggests a potential involvement of ECRG4 in pathophysiological functions of the brain. - Source: PubMed
Publication date: 2026/04/23
Oikawa NaotoZhang LifuKondo Toru - Although immune dysregulation is implicated in both autoimmune diseases and cancer, comparative pathogenesis and immune response mechanisms between systemic lupus erythematosus (SLE) and colorectal cancer (CRC) remain elusive. This study identifies common molecular biomarkers and pathogenic pathways shared between SLE and CRC via multi-omics analysis. - Source: PubMed
Publication date: 2026/02/26
Guan HuiTian ChengziZhong MingZhang LihuanWang WenjingHuang MingchengChen Duo - This study aims to investigate the molecular mechanisms by which ECRG4 regulates breast cancer progression, with a focus on its tumor-suppressive effects mediated through the NFIC/PTEN and SHP2/PI3K/SP1 signaling pathways. - Source: PubMed
Publication date: 2026/02/09
Song DanWei YusenZhao XiaofeiNing Dianbin - Colorectal cancer (CRC) is one of the most common causes of cancer mortality worldwide. The transcription factor Myc-associated zinc finger protein (MAZ) has been implicated in cancer progression. However, its precise function and mechanisms in CRC remain unclear. - Source: PubMed
Mao Hui-QinYu Fang-CaoHu Dan-QiongZhang Li-Jing