Ask about this productRelated genes to: C2orf40 antibody
- Gene:
- ECRG4 NIH gene
- Name:
- ECRG4 augurin precursor
- Previous symbol:
- C2orf40
- Synonyms:
- augurin
- Chromosome:
- 2q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-07-31
- Date modifiied:
- 2019-04-18
Related products to: C2orf40 antibody
Related articles to: C2orf40 antibody
- Esophageal cancer-related gene-4 (ECRG4) is a hormone-like protein that acts as a tumor suppressor by inducing cell death through apoptosis and cell-cycle arrest. ECRG4 is expressed in various organs, including the brain, and it influences the viability and function of neural cells such as oligodendrocytes and microglia. However, the effects of ECRG4 on astrocytes, which are essential neural cells that play significant roles in maintaining brain homeostasis, remain unclear. In this study, we demonstrate that ECRG4, specifically the region encompassing amino acids 71-107 (ECRG4(71-107)), induces cell death in mouse primary astrocytes. The ECRG4(71-107)-induced astrocyte death is associated with lysosomal damage and is mediated by cathepsins, indicating a lysosome-dependent cell death mechanism. Notably, ECRG4(71-107) promotes the secretion of cathepsins into the extracellular space. The introduction of exogenous cathepsins into the medium induced astrocyte death, while the removal of cathepsins from the conditioned medium reduced the toxicity associated with ECRG4(71-107). These findings suggest that extracellular cathepsins mediate the toxicity of ECRG4(71-107) in astrocytes. Overall, this study reveals a novel mechanism of cell death induced by ECRG4 in astrocytes and suggests a potential involvement of ECRG4 in pathophysiological functions of the brain. - Source: PubMed
Publication date: 2026/04/23
Oikawa NaotoZhang LifuKondo Toru - Although immune dysregulation is implicated in both autoimmune diseases and cancer, comparative pathogenesis and immune response mechanisms between systemic lupus erythematosus (SLE) and colorectal cancer (CRC) remain elusive. This study identifies common molecular biomarkers and pathogenic pathways shared between SLE and CRC via multi-omics analysis. - Source: PubMed
Publication date: 2026/02/26
Guan HuiTian ChengziZhong MingZhang LihuanWang WenjingHuang MingchengChen Duo - This study aims to investigate the molecular mechanisms by which ECRG4 regulates breast cancer progression, with a focus on its tumor-suppressive effects mediated through the NFIC/PTEN and SHP2/PI3K/SP1 signaling pathways. - Source: PubMed
Publication date: 2026/02/09
Song DanWei YusenZhao XiaofeiNing Dianbin - Colorectal cancer (CRC) is one of the most common causes of cancer mortality worldwide. The transcription factor Myc-associated zinc finger protein (MAZ) has been implicated in cancer progression. However, its precise function and mechanisms in CRC remain unclear. - Source: PubMed
Mao Hui-QinYu Fang-CaoHu Dan-QiongZhang Li-Jing - Endometriosis (EMS) is a common chronic gynecological disorder that increases the risk of ovarian cancer by approximately threefold. However, the molecular mechanisms underlying this association remain unclear. - Source: PubMed
Publication date: 2025/09/26
Lin PeihongWu LingLai XuedanXiao ChenxinYe Jianwen