Ask about this productRelated genes to: C1orf50 antibody
- Gene:
- C1orf50 NIH gene
- Name:
- chromosome 1 open reading frame 50
- Previous symbol:
- -
- Synonyms:
- MGC955
- Chromosome:
- 1p34.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-31
- Date modifiied:
- 2016-10-24
Related products to: C1orf50 antibody
Related articles to: C1orf50 antibody
- C1orf50 encodes a small, evolutionarily conserved protein, the function of which remains unclear. Its significance across various human cancers, particularly its specific role in ovarian cancer within an immunogenomic context, is not yet fully understood. Utilizing The Cancer Genome Atlas and single-cell RNA sequencing (scRNA-seq) public datasets, we conducted a comprehensive profiling of C1orf50 across multiple cancer types, with a particular focus on ovarian cancer, to investigate its associations with copy-number status, genomic instability, tumor programs, and the immune microenvironment. - Source: PubMed
Publication date: 2025/12/08
Rogachevskaya AnnaOtani YusukeOhtsu AkiraChin Vanessa DPeña TirsoArai SeijiToyooka ShinichiFujimura AtsushiTanaka Atsushi - Hepatocellular carcinoma (HCC) is a heterogeneous liver cancer with limited treatment options and a poor prognosis in advanced stages. To identify novel biomarkers and therapeutic targets, we investigated the role of chromosome 1 open reading frame 50 (), a gene with a previously uncharacterized function in HCC. - Source: PubMed
Tanaka AtsushiOtani YusukeMaekawa MasakiRogachevskaya AnnaPeña TirsoChin Vanessa DToyooka ShinichiRoehrl Michael HFujimura Atsushi - Recent advancements in omics analysis have significantly enhanced our understanding of the molecular pathology of malignant melanoma, leading to the development of novel therapeutic strategies that target specific vulnerabilities within the disease. Despite these improvements, the factors contributing to the poor prognosis of patients with malignant melanoma remain incompletely understood. The aim of this study was to investigate the role of (Chromosome 1 open reading frame 50), a gene previously of unknown function, as a prognostic biomarker in melanoma. - Source: PubMed
Publication date: 2025/06/26
Otani YusukeMaekawa MasakiTanaka AtsushiPeña TirsoChin Vanessa DRogachevskaya AnnaToyooka ShinichiRoehrl Michael HFujimura Atsushi - Although the prognosis of breast cancer has significantly improved compared to other types of cancer, there are still some patients who expire due to recurrence or metastasis. Therefore, it is necessary to develop a method to identify patients with poor prognosis at the early stages of cancer. In the process of discovering new prognostic markers from genes of unknown function, we found that the expression of C1orf50 determines the prognosis of breast cancer patients, especially for those with Luminal A breast cancer. This study aims to elucidate the molecular role of C1orf50 in breast cancer progression. Bioinformatic analyses of the breast cancer dataset of TCGA, and in vitro analyses, reveal the molecular pathways influenced by C1orf50 expression. C1orf50 knockdown suppressed the cell cycle of breast cancer cells and weakened their ability to maintain the undifferentiated state and self-renewal capacity. Interestingly, upregulation of C1orf50 increased sensitivity to CDK4/6 inhibition. In addition, C1orf50 was found to be more abundant in breast cancer cells than in normal breast epithelium, suggesting C1orf50's involvement in breast cancer pathogenesis. Furthermore, the mRNA expression level of C1orf50 was positively correlated with the expression of PD-L1 and its related factors. These results suggest that C1orf50 promotes breast cancer progression through cell cycle upregulation, maintenance of cancer stemness, and immune evasion mechanisms. Our study uncovers the biological functions of C1orf50 in Luminal breast cancer progression, a finding not previously reported in any type of cancer. - Source: PubMed
Publication date: 2024/11/28
Otani YusukeTanaka AtsushiMaekawa MasakiPeña TirsoRogachevskaya AnnaAndo TeruhikoItano TakutoKatayama HaruyoshiNakata EijiOzaki ToshifumiToyooka ShinichiDoihara HiroyoshiRoehrl Michael HFujimura Atsushi