Ask about this productRelated genes to: BCHE antibody
- Gene:
- BCHE NIH gene
- Name:
- butyrylcholinesterase
- Previous symbol:
- CHE1, CHE2
- Synonyms:
- E1
- Chromosome:
- 3q26.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: BCHE antibody
Related articles to: BCHE antibody
- Alnus nitida-derived silver nanoparticles (An-AgNPs) were fabricated using the leaf extract of this medicinal plant, selected for its rich phytochemical profile and strong reducing potential, through a green synthesis approach. The synthesized nanoparticles were previously characterized using standard physicochemical techniques, confirming their nanoscale size, stability, and functional groups responsible for reduction and capping. An-AgNPs and leaves extract were evaluated for their antioxidant (DPPH and ABTS), anti-bacterial, anti-cholinesterase (acetylcholinesterase (AChE), butyrylcholinesterase (BChE)), and anti-diabetic (α-amylase and α-glucosidase) potentials. An-AgNPs showed potent DPPH and ABTS scavenging activities with IC50 values of 125 and 115 µg/mL, followed by leaves extract with IC50 values of 930 and 400 µg/mL, respectively. An-AgNPs also exhibited potential inhibitory activities against AChE, BChE, amylase, and glucosidase with IC50 values of 63, 65, 160, and 65 µg/mL, respectively, whereas the leaves extract exhibited IC50 values of 70, 100, 215, and 235 µg/mL, respectively. The micro-titre plate-based assay of An-AgNPs showed excellent antibacterial activity against both gram-positive bacteria, Staphylococcus aureus (93.76%), Bacillus subtilis (88.35%), and gram-negative bacteria, Escherichia coli (87.67%), Pseudomonas aeruginosa (91.65%), Salmonella typhi (92.28%). The findings of the study demonstrate that An-AgNPs possess significant multifunctional bioactivities and highlight their potential for biomedical and pharmaceutical applications. - Source: PubMed
Publication date: 2026/04/24
Zahoor MuhammadKhan SajadKhan Raham SherIslam Noor UlIkram MuhammadAlotaibi Amal - Solanum surattense is traditionally used to treat gastrointestinal disorders, and although its chemical constituents and some pharmacological properties have been documented, its comprehensive pharmacological profile remains insufficiently characterized, necessitating further systematic investigation. The current study aimed to investigate its phyto-constituents and to assess its antioxidant, anticholinesterase, antidiarrheal, and spasmogenic/spasmolytic activities. Bioassay-guided fractionation of the whole plant extract was performed using Dichloromethane and Ethyl acetate. GC-MS revealed 8 compounds in the dichloromethane fraction of S. surattense (DCMFSS), such as Loliolide and n-hexadecanoic acid, which showed the highest percent area (1.23%), and 10 in the ethyl acetate fraction of S. surattense (EAFSS), such as 3-Hydroxy-4-methoxybenzoic acid, 4-Vinylphenol, with the highest percent area (7.55%). Both fractions exhibited significant antioxidant activity in the DPPH and ABTS assays with IC of 199/162 µg mL (DCMFSS) and 135/150 µg mL (EAFSS), respectively. DCMFSS and EAFSS exhibited anticholinesterase activity with IC values of 22/3 µg mL and 3/6 µg mL against AChE and BChE, respectively. In vivo experiments on pigeons presented significant decreases in diarrhea and intestinal transit in comparison with controls. Ex vivo studies on isolated rabbit jejunum demonstrated a biphasic effect: both fractions had spasmogenic activity at lower dosages (0.01-1.0 mg mL) and spasmolytic activity at higher dosages (3-15 mg mL). EC values against spontaneous contraction were 8.67 ± 0.43 mg mL (DCMFSS) and 12.16 ± 0.49 mg mL (EAFSS), whereas against KCl-induced contraction, the values were 10.19 ± 0.34 and 9.98 ± 0.59 mg mL respectively. These results mechanistically support the traditional use of S. surattense and highlight its potential for developing new therapeutic drugs for gastrointestinal disorders. - Source: PubMed
Tabassum SumairaIqbal ArshadSher Ayaz AliNabi MuhammadNawaz NighatRahman Atta UrBibi ShaziaGenc Husnu CagriBüyüker Sultan Mehtap - Alzheimer's disease (AD) is a neurodegenerative disease characterized by dementia, particularly in older adults. It is a process that is increasing significantly with the aging population worldwide, has yet to be cured, and therefore challenges healthcare systems. The ability of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors to modulate neurotransmitter levels has made AChE/BChE inhibitors central therapeutic targets in drug development studies for the treatment of AD. Previous studies have demonstrated the beneficial effects of pyrimidine derivatives on cognitive functions and highlighted their high therapeutic potential against neurodegenerative diseases. Considering the pharmacological importance of AChE/BChE inhibitors and pyrimidine derivatives, this study investigated the inhibitory potential of seven different pyrimidine derivatives (1-7) on AChE and BChE using both in vitro and in silico approaches. Analysis of IC values indicated that compounds 1-7 (IC: 14.89-77.70 nM) exhibited strong inhibitory effect. Compound 6 (IC:14.89 nM) had the strongest inhibitory effect on AChE, while it showed a much weaker inhibitory effect against BChE (IC: 357 nM), corresponding to an approximately 24-fold selectivity for AChE. Molecular modeling results indicate that compounds 6 and 7 exhibit favorable interactions within the active site of the enzyme. In addition, compounds 1 and 3, which exhibited the strongest inhibitory effects on BChE, appear to display a multiple binding profile with the active site of BChE. Correlation and regression analyses indicated that compounds 1-7 display a structure-activity relationship (SAR) consistent with strong inhibitory potency toward AChE, while showing comparatively weaker inhibition toward BChE. - Source: PubMed
Publication date: 2026/04/23
Alım ZuhalDemir Yeliz - A series of novel coumarin-triazole hybrids (12a-s) were synthesized and evaluated for their inhibitory activities against cholinesterase including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), enzymes related to Alzheimer's disease. The structure-activity relationship (SAR) analysis revealed that substitutions at the 2-position of the aromatic ring significantly enhanced anti-BChE potency, with compound 12c (2-fluorophenyl) exhibiting moderate activity with IC = 4.37 ± 0.91 µM for BChE and 7.17 ± 0.42 µM for AChE. Docking studies demonstrated strong binding interactions of 12c with critical residues in the active site of the enzyme. Molecular dynamics simulations confirmed the stability of the 12c-AChE and 12c-BChE complexes over 100 ns, with low RMSD values and stable hydrogen bonding. These findings highlight the importance of electronic and steric effects in optimizing cholinesterase inhibition and provide insights into the design of effective agents for Alzheimer's disease therapy. - Source: PubMed
Publication date: 2026/04/20
Kermaninia ShahabFarnia MortezaMahdavi MohammadIraji Aida - Pistachios ( L.) are a significant food that is added to many foods and also consumed as a snack. The kernel part is consumed very much. In this study, 53 phytochemical constituents of three pistachio varieties (Halebi, Kırmızı, and Uzun) were profiled by LC-MS/MS, and their antioxidant capacity (total phenolic and flavonoid content, ABTS, DPPH, CUPRAC, FRAP, MCA, and phosphomolybdenum assays), antidiabetic activity (α-amylase and α-glucosidase inhibition), anticholinergic activity (AChE and BChE inhibition), and wound healing potential (tyrosinase inhibition) were evaluated. Additionally, molecular docking was used to examine the binding interactions of the major phytochemicals with each enzyme. The major phytochemical ingredients were tannic acid (24.005 mg/g), catechin (11.284 mg/g), protocatechuic acid (6.202 mg/g), gallic acid (5.717 mg/g), epicatechin gallate (1.686 mg/g), and epigallocatechin gallate (1.139 mg). The highest antioxidant properties were obtained in the Uzun variety in all assays. Antioxidant properties were high in all three varieties. While wound healing potential was high across all three varieties (30-43 mg GALAE/g), their anticholinesterase (2.06-2.54 mg GALAE/g) and antidiabetic activities (0.64-2.94 mmol ACAE/g) were comparatively low. Major bioactive phytochemicals were discovered to have highly favorable docking scores. This study determined that three types of pistachios contain significant bioactive compounds and are a very nutritious food due to the diversity of their biological activities. - Source: PubMed
Publication date: 2026/03/23
İzol EbubekirBeltekin BüşraTurhan MünireKarakoç ŞirvanNecip AdemYılmaz Mustafa AbdullahZengin GökhanÇakır Oğuz