Ask about this productRelated genes to: ASCC2 antibody
- Gene:
- ASCC2 NIH gene
- Name:
- activating signal cointegrator 1 complex subunit 2
- Previous symbol:
- -
- Synonyms:
- ASC1p100, FLJ21588, DKFZp586O0223
- Chromosome:
- 22q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-27
- Date modifiied:
- 2016-10-05
Related products to: ASCC2 antibody
Related articles to: ASCC2 antibody
- The activating signal co-integrator 1 complex subunit 3 (ASCC3) is a multifunctional protein. However, little is known about its role in replication stress. Here, we report that ASCC3 is recruited to stalled forks by its binding partner ASCC2, whose recruitment to stalled forks requires both its ubiquitin binding activity and polyubiquitylation of PCNA at K164 catalyzed by SHPRH, HLTF, and RFWD3. Upon replication stress, ASCC3 unwinds DNA, and this unwinding activity is required for SMARCAL1 recruitment, restrained fork progression, and fork degradation in BRCA1/BRCA2-deficient cells. ASCC3 unwinds DNA to remodel gap-containing fork substrates in vitro, suggesting that ASCC3 promotes fork reversal. In addition, ASCC3 stimulates RPA accumulation on ssDNA upon replication stress, promoting efficient ATR activation. Furthermore, ASCC3 antagonizes RAD51-mediated recombination and prevents the accumulation of chromosome breaks/gaps and mis-segregation upon replication stress. Our work underscores a critical role of ASCC3 in controlling multiple replication stress responses to maintain genomic stability. - Source: PubMed
Publication date: 2026/03/04
Cui ShixinBatenburg Nicole LCoulombe YanArumugam ArunaWalker John RSheida Sadaf ValehBielinsky Anja-KatrinWahl Markus CMasson Jean-YvesZhu Xu-Dong - Long non-coding RNA (lncRNA) has been implicated in tumorigenesis, yet its mechanistic role in gastric cancer (GC) remains elusive. - Source: PubMed
Publication date: 2026/01/02
Zhang XiaoyanWang XinWang QiWang XuSun HuiLiu YingxueTan CongNi ShujuanWeng WeiweiZhang MengWang LeiHuang DanChen JieWang XiaoyuGan LuAbudurexiti MierxiatiWang WenfengChang JinjiaSheng WeiqiXu Midie - The Activating Signal Cointegrator 1 (ASC-1) complex is a tetrameric complex composed of Thyroid Hormone Receptor Interactor 4 (TRIP4), Activating Signal Cointegrator 1 (ASCC1), Activating Signal Cointegrator 2 (ASCC2), and Activating Signal Cointegrator 3 (ASCC3). As the core subunit of the ASC-1 complex, ASCC3 is involved in DNA damage repair. However, the exact role of ASCC3 in digestive system cancers, particularly in rectal adenocarcinoma (READ), remains unclear. - Source: PubMed
Publication date: 2025/08/13
Miao ChuangQian Fei - The activating signal co-integrator 1 complex subunit 3 (ASCC3), the largest subunit of ASCC, is one of two Ski2-like helicases with duplicated helicase cassettes encoded by the human genome. ASCC3 has been implicated in transcriptional regulation, alkylation damage repair, and ribosome quality control. In addition, published proteomics studies suggest that ASCC3 is associated with stalled forks. However, little is known about its role in replication stress. Here we report that ASCC3 is recruited to stalled forks by its binding partner ASCC2, whose recruitment to stalled forks is dependent upon both its ubiquitin binding activity and polyubiquitylation of PCNA at K164 that is catalyzed by SHPRH, HLTF, and RFWD3. In response to replication stress. ASCC3 unwinds DNA, generating both parental and nascent ssDNA. This unwinding activity is required to promote fork reversal. We demonstrate that ASCC3 also interacts with RPA and stimulates RPA accumulation on ssDNA upon replication stress, promoting ATR activation. Furthermore, ASCC3 functions to antagonize RAD51-mediated recombination and prevents accumulation of chromosome breaks/gaps and mis-segregation in response to replication stress. Our work underscores a previously uncharacterized but critical role of ASCC3 in controlling multiple replication stress responses to maintain genomic stability. - Source: PubMed
Publication date: 2025/07/26
Cui ShixinBatenburg Nicole LCoulombe YanArumugam ArunaWalker John RSheida Sadaf ValehBielinsky Anja-KatrinWahl Markus CMasson Jean-YvesZhu Xu-Dong - The ASC-1 complex, consisting of TRIP4, ASCC1, ASCC2, and ASCC3, plays a pivotal role in regulating nuclear receptors and transcription factors that influence immunity, cellular proliferation, and apoptosis, and a multiomic analysis of ASCC1/2/3 was therefore performed to investigate its potential role on a pan-cancer scale. Although it has been implicated in DNA repair mechanisms and neurodegenerative diseases, its specific function within cancer biology remains poorly understood. This study conducted a pan-cancer analysis of ASCC1/2/3's roles in the tumorigenesis process and explored their regulatory effects on lung adenocarcinoma. We conducted a comprehensive analysis of 10,967 tumor samples across 30 distinct cancer types. It was found that alterations in ASCC1/2/3 occurred in 754 cases (7% of the patients analyzed), with ASCC3 being the most frequently altered at 4%. Furthermore, elevated expression levels of ASCC1/2/3 were observed in the majority of cancer types examined. Notably, the expression levels of ASCC1 and ASCC3 demonstrated a correlation with CD4-positive T cell infiltration. In vitro experiments demonstrated that the ASCC family effectively inhibited tumor proliferation, migration, and invasion in lung adenocarcinoma cell line. Our findings indicate a significant association between the ASCC family and tumors while providing a foundation for further investigation into its role in cancer biology and potential clinical applications. - Source: PubMed
Publication date: 2025/07/02
Pan YiminTan JunWu ChangwuLiu ChunboChen ZhengZhu YongyeLuo FushuLiu Qing