Ask about this productRelated genes to: ARNT antibody
- Gene:
- ARNT NIH gene
- Name:
- aryl hydrocarbon receptor nuclear translocator
- Previous symbol:
- -
- Synonyms:
- HIF-1beta, bHLHe2
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-01-22
- Date modifiied:
- 2016-10-05
Related products to: ARNT antibody
Related articles to: ARNT antibody
- Placental hypoxia and vascular dysfunction are hallmarks of preeclampsia (PE). The Breast Cancer Resistance Protein (BCRP) is critical for maintaining the placental barrier against oxidative stress. We investigated whether the hypoxic microenvironment drives BCRP dysregulation and how this correlates with fetal growth restriction (FGR) in severe preeclampsia. - Source: PubMed
Publication date: 2026/06/22
Shi JingjingZhu WenxuanLiu HaixiaYang PingGu YongzhongPeng WenMeng Jinlai - Aryl hydrocarbon receptor nuclear translocator 2 is a member of the basic helix-loop-helix/Per-ARNT-Sim (bHLH-PAS) family of transcription factors involved in responding to various environmental, metabolic, and chemical signals. Initially known for its involvement in neurodevelopment, ARNT2 is now recognized as an essential binding partner for other transcription factors, including single-minded homologs 1 and 2 (SIM1, SIM2), neuronal PAS domain protein 4 (NPAS4), hypoxia-inducible factor 1 (HIF1), and plausibly Aryl hydrocarbon Receptor (AHR) to regulate stress adaptation, synaptic plasticity, immune signaling, and energy balance pathways. The role of ARNT2 has also been implicated in a plethora of pathologies, including inflammation, cardiovascular diseases, neurological disorders, metabolic diseases, and cancers. This review summarizes the current knowledge of ARNT2's structure, regulation, interacting partners, and its toxicopathological significance. A better understanding of ARNT2 biology may open new avenues for its characterization as a molecular target and designing novel therapeutic strategies across multiple diseases. - Source: PubMed
Publication date: 2026/06/30
Jahan IsratSerrano Matos Yadeliz AJayaraman ArulJoshi Aditya D - 1. Calcium (Ca) is essential for avian embryonic bone mineralisation, yet its metabolic dynamics during duck embryogenesis remain unclear. This study investigated Ca mobilisation in Muscovy duck embryos.2. Eggshell (ES) and yolk samples were collected from embryonic day (ED) 16 to ED31 for analysis of ES physical properties (thickness, strength, mass ratio) and Ca levels. Serum, yolk sac membrane (YSM) and liver tissues were collected from ED16 to the day of hatch (DOH) to assess serum biochemical parameters and relative mRNA expression of genes associated with Ca transport (, , ) and absorption (, , ).3. Results showed ES quality and Ca levels decreased ( < 0.01) linearly with increasing incubation days. Yolk Ca levels decreased ( < 0.01) linearly and quadratically, reaching a minimum on ED25. Serum Ca levels and alkaline phosphatase (ALP) activity increased ( < 0.01) linearly and quadratically during ED16-DOH and achieved a plateau during ED28-DOH. Expression of Ca-related genes in YSM and liver increased quadratically ( < 0.01), peaking during ED25-28.4. In conclusion, ES quality declined with reduced Ca levels during embryogenesis. Concurrently, yolk Ca levels, along with serum Ca and ALP levels, increased significantly during ED25-28, indicating peak embryonic Ca mobilisation during this period. Additionally, relative mRNA expression of Ca mobilisation-related genes in the YSM and liver exhibited a similar increasing trend. This suggested enhanced Ca mobilisation during this phase to support bone mineralisation and growth in duck embryos. - Source: PubMed
Publication date: 2026/06/24
Wang XRen YHu QWu QSun GChen HLin JLiu SWang WQin JZhu Y - Epigenetic mechanisms are considered adaptive regulators of gene expression, yet mechanisms driving aging-associated DNA methylation remain unclear. Prior work hinted that epigenetic aging might reflect a response to oxygen availability, with age‑differential methylation in immune cells enriched near binding sites for hypoxia‑responsive factors ARNT and REST. To test this hypothesis, we exposed adult (11 months) and old (23 months) mice to 1 month of intermittent hypoxia (IH) followed by normoxic recovery. IH induced epigenetic age acceleration in lungs, spleen, and heart in old mice only. This acceleration reversed upon return to normoxia. Reversible shifts were enriched at bivalent domains and PRC2 targets, indicating oxygen-sensitive chromatin remodeling. Human translational validation in young adults at high altitude (5260 m) confirmed rapid, conserved epigenetic aging. Our findings establish oxygen availability as a primary, conserved modulator of epigenetic aging across tissues and species, showing that oxygen fluctuations are a potent, reversible driver of epigenetic aging. - Source: PubMed
Publication date: 2026/06/23
Donega StefanoLu Ake THaghani AminHorvath MarkusYan QiBaranzini MirkoEscote Maxine TheaRossi MartinaHernandez Rolando JMcDevitt Ross AFishbein Kenneth WHorvath SteveFerrucci Luigi - The aryl hydrocarbon receptor (AHR) plays a key role in immune regulation and drug metabolism, potentially influencing methotrexate (MTX) treatment outcomes in patients with rheumatoid arthritis (RA). This exploratory study investigated the relationship between AHR activity and MTX responsiveness, and examined whether combination therapy with tocilizumab (TCZ), an interleukin (IL)-6 receptor inhibitor, could influence MTX resistance and treatment response. - Source: PubMed
Publication date: 2026/06/22
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