Ask about this productRelated genes to: ANXA11 antibody
- Gene:
- ANXA11 NIH gene
- Name:
- annexin A11
- Previous symbol:
- ANX11
- Synonyms:
- -
- Chromosome:
- 10q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-17
- Date modifiied:
- 2014-11-19
Related products to: ANXA11 antibody
Related articles to: ANXA11 antibody
- The absence of a cell wall affords animal cells diverse functionality at the cost of acute sensitization to plasma membrane (PM) damage. Thus, animal cells tightly monitor and maintain PM integrity to prevent cell death. Genetic loss of PM repair factors is associated with human diseases such as muscular dystrophy. Despite evidence that annexin and endosomal sorting complex required for transport (ESCRT) proteins are required for PM repair, the extent to which their recruitment is coordinated at sites of membrane damage remains unclear. Here, leveraging quantitative organellar proteomics and genome-wide CRISPR interference screens, we identify sorcin as a PM repair factor that couples annexin A11 (ANXA11)-mediated sensing of PM damage to ESCRT-III assembly. We show that sorcin directly binds ANXA11 and ALIX in the presence of Ca via its penta-EF-hand domain and flexible N terminus, respectively, and is required for ESCRT-III recruitment to PM lesions and membrane resealing. Our data support a model in which ANXA11, recruited to the PM upon damage-induced Ca influx, serves as an anchor that facilitates the sequential recruitment of sorcin and ESCRT-III at PM lesions. Together, these findings establish a Ca-dependent scaffolding mechanism that couples PM damage sensing to ESCRT-III assembly for PM repair. - Source: PubMed
Publication date: 2026/08/10
Ngo Jordan MatthewWilliams Justin KrishMurugupandiyan AbinayaaSchekman Randy - Hypertension is a leading contributor to cardiovascular disease in people with HIV (PWH), yet its underlying molecular mechanisms remain poorly understood. - Source: PubMed
Publication date: 2026/06/16
Okello SamsonGraff MariaelisaJustice Anne EHoward Annie GreenJamieson Beth DShih RogerMcKay HeatherShrestha SadeepMeyers JacquelynKim Eun-YoungKassaye SebleGolzar YasmeenHanna David BChoudhary Madhu ChhandaRubtsova Anna AFischl Margaret AWu Katherine CAsam KesavaRamirez CatalinaAouizerat Bradley EEdmonds AndrewNorth Kari E - Plasma membrane damage can cause cell death and is associated with neurodegeneration. In this issue of Developmental Cell, Heffner et al. show that annexin A11 (ANXA11) first plugs membrane lesions, before ESCRT-III is recruited to extrude the damaged patch-a two-step repair mechanism compromised by ALS- and FTD-linked mutations. - Source: PubMed
Kournoutis AthanasiosStenmark Harald - Annexin A11 (ANXA11) is a Ca⁺-dependent phospholipid-binding protein that has recently emerged as a key player in neurodegeneration. Rare pathogenic ANXA11 variants were initially identified in cases of amyotrophic lateral sclerosis (ALS). Since then, ANXA11 has been linked to a broader spectrum of related neurodegenerative diseases. Two independent studies demonstrated that ANXA11 co-aggregates with TDP-43 in all cases of frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type C, with cryo-EM revealing heteromeric ANXA11-TDP-43 filaments. These discoveries support the direct pathological interaction between the two proteins as an important feature of FTLD-TDP type C. We also described secondary ANXA11 pathology in related neurodegenerative diseases, including limbic-predominant age-related TDP-43 encephalopathy (LATE), and more rarely in ALS and FTLD-TDP types A and B. ANXA11 and TDP-43 co-aggregates are also a feature of a FTLD-TDP associated with primary lateral sclerosis. These advances have renewed interest in ANXA11 as a major player in ALS/FTLD pathogenesis in both genetic and sporadic neurodegenerative diseases. In this review, we summarize ANXA11 pathology across genetic and sporadic cases, highlighting its heterogeneous overlap with TDP-43 pathology. We synthesize current knowledge of ANXA11's physiological roles in phase separation, membrane repair, and RNA granule dynamics, integrating emerging evidence on how disruption of these processes may promote pathological aggregation and toxicity. Finally, we outline priorities for future research, with particular emphasis on elucidating ANXA11's mechanistic connection to TDP-43. - Source: PubMed
Publication date: 2026/07/07
Smith Courtney LRobinson John LLee Edward B - Tumor-associated neutrophils (TANs) play a crucial role in the tumor microenvironment of colorectal cancer (CRC). Although Annexin A11 (ANXA11) is highly expressed in CRC tissues, its prognostic value and its mechanism in mediating tumor-neutrophil crosstalk to drive CRC progression require further investigation. - Source: PubMed
Publication date: 2026/07/06
Jin DandanZhao JunpengXu WeisongZhao RanJi JieJiao YujieWu TongXu XuebingShi ZihanZhao MingxinLi TaoLu XiaominHuang JianfeiXiao Mingbing