Ask about this productRelated genes to: AMY2A antibody
- Gene:
- AMY2A NIH gene
- Name:
- amylase alpha 2A (pancreatic)
- Previous symbol:
- AMY2
- Synonyms:
- -
- Chromosome:
- 1p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-01-18
Related products to: AMY2A antibody
Related articles to: AMY2A antibody
- Acute pancreatitis involves the self-digestion of pancreatic tissue caused by the abnormal activation of pancreatic enzymes. The disease progresses rapidly, and severe acute pancreatitis (SAP) has a high mortality rate. Currently, there are no satisfactory treatments for SAP. The Tongfu Huayu Formula (TFHYF) is a modified version of the Dachengqi decoction, which has proven to be effective against SAP in clinical research. However, the mechanism of action is unclear. - Source: PubMed
Publication date: 2026/01/27
Wang XiwangWang YingJin JingjingWei KaiDong ShuoLiu XiangliWang Xiao - Rice eating and cooking quality (ECQ) is a key determinant of consumer preference and market value, governed by complex genetic and biochemical mechanisms. This study aimed to dissect the genetic architecture underlying three major ECQ-related traits including amylose content (AC), gelatinization temperature (GT), and gel consistency (GC), using a panel of 243 diverse rice accessions through a genome-wide association study (GWAS), epistatic interaction analysis, haplotype analysis, and gene expression profiling. Phenotypic evaluation revealed extensive variability for all three traits, accompanied by high narrow-sense heritability estimates, indicating strong genetic control. Based on the FarmCPU model, 29 significant SNPs corresponding to 23 quantitative trait loci (QTLs)-11 for GT, 6 for GC, and 6 for AC-were identified across 10 chromosomes. Among them, qAC6-1, overlapping with the Waxy (WX1/GBSS1) gene, was determined as the major locus for AC; qGC2-1 on chromosome 2 emerged as the principal region governing GC; and three major GT-related QTLs (qGT6-1, qGT6-2, qGT6-3) were located near the SSIIa gene on chromosome 6. Epistatic analysis revealed 18 significant interactions (4 for AC, 6 for GC, and 8 for GT), underscoring the polygenic and interactive nature of rice quality traits. Haplotype analysis within qGC2-1 identified three haplogroups, among which H001-defined by the SNP combination "G/T/G/A"-was associated with superior gel consistency. Functional annotation and RNA-Seq expression profiling identified 12 candidate genes potentially involved in ECQ regulation, including WX1, Amy2A, IRX9, OsNAC1, PMEI25, and OsFbox132. Quantitative RT-PCR validated the expression of key genes (WX1, Amy2A, and IRX9) at different seed developmental stages in high- and low-quality rice genotypes. Overall, the integration of genomic, haplotypic, and transcriptional analyses provides new insights into the molecular control of rice grain quality. The identified QTLs, candidate genes, and favorable haplotypes serve as valuable genomic resources for marker-assisted selection and molecular breeding strategies aimed at developing rice varieties with superior eating and cooking qualities. - Source: PubMed
Publication date: 2025/12/28
Farzad Amirebrahimi FatemehSaidi AbbasAhmadikhah Asadollah - Insoluble fibre has been shown to be a functional fibre that helps the effective use of nutrients and energy through the gastrointestinal tract, and as such may be added to diets to enhance the growth performance of broilers. This study aimed to investigate the effects of insoluble fibre sources in a reduced protein (RP) diet fed to broilers. At d 10 post-hatch, 672 d-old Ross 308 male birds were assigned to 6 treatments with 8 replicates of 14 birds each. The treatments were a normal protein (NP) diet, a RP diet (-20 g/kg protein), and RP diets formulated with either sugarcane bagasse at 20 g/kg, lignocellulose-based fibre at 10 g/kg, oat hulls at 30 g/kg, or soy hulls at 30 g/kg. The results showed that the reduction in dietary protein decreased feed intake and weight gain, and worsened feed conversion ratio (FCR; < 0.05). The birds fed the RP diet with soy hulls or bagasse had a better FCR ( < 0.05) compared to those fed the RP diet without fibre and similar FCR to those fed a NP diet. Bagasse or soy hulls supplementation in the RP diet decreased ( < 0.05) the starch digestibility coefficient compared to the RP diet without fibre. Lower counts ( < 0.05) of in birds offered the RP diet with bagasse or oat hulls was observed compared to the RP diet alone. The difference ( = 0.011) in the expression of digestive enzyme genes in response to dietary treatments was observed for the gene in the pancreas. The reduction in dietary crude protein (CP) downregulated ( < 0.05) the gene and the addition of the four insoluble fibres to the RP diet had no effect on the expression of compared to the RP treatment but bagasse, lignocellulose, and soy hulls added RP diets had similar expression as the NP treatment. It was concluded that reducing dietary protein compromised the growth performance of broilers which was partially attenuated by supplementing the diets with bagasse or soy hulls. - Source: PubMed
Publication date: 2025/08/26
Sharma Nishchal KKheravii Sarbast KChoct MinganGurney KarenWu Shu-Biao - People of South Asian (SA) origin have an elevated risk of cardiometabolic dysfunction and respond differentially to physical activity. Mechanisms underpinning these observations are incompletely understood. We investigated protein signatures of ethnicity, changing physical activity and their interaction. - Source: PubMed
Publication date: 2025/11/03
Henson JosephGhit AmrTziannou AikaterinaJames EmilyEdwardson Charlotte LBishop Nicolette CRazieh CameronJones Donald J LCao Thong HuyDavies Melanie JKhunti KamleshYates Thomas - Improving feed efficiency in Tianchang Sanhuang chickens is essential for reducing production costs and environmental burden. The objective of this study was to integrate transcriptomic and metabolomic analyses to identify key regulatory genes, metabolites, and pathways associated with residual feed intake (RFI) and feed efficiency. In this study, 650 Tianchang Sanhuang laying hens with similar body weights at 36 weeks of age were evaluated for daily feed intake (DFI), RFI, and feed conversion ratio (FCR). The chickens were classified by RFI (mean ± 0.5 SD) into high-RFI (HRFI, n = 165) and low-RFI (LRFI, n = 158) groups. Phenotypes, serum biochemistry, antioxidant indices, and intestinal traits were compared in subsets (n = 8 per group). Duodenal transcriptomes (RNA-seq) and serum metabolomes (LC-MS/MS) were profiled in independent subsets (n = 4 per group). Compared with HRFI, LRFI hens showed lower RFI, FCR, and DFI (P < 0.01), with no differences in expected feed intake (EFI), metabolic body weight (MBW), daily egg mass (DEM), or average daily gain (ADG) (P > 0.05). The LRFI group showed increased breast muscle redness (a)* (P < 0.05), higher leg muscle drip loss (P < 0.01), and significantly lower levels of triglycerides (TG), cholesterol (CHO), low-density lipoprotein cholesterol (LDL-C), and malondialdehyde (MDA) (P < 0.05). The intestinal morphology and molecular analyses revealed enhanced nutrient absorption and intestinal barrier function in the LRFI group. Transcriptomic analysis identified 237 differentially expressed genes (P < 0.05, |log2FC| ≥ 1) enriched in pathways related to digestion, energy metabolism, and appetite regulation. Metabolomic analysis detected 101 differentially expressed metabolites (VIP ≥ 1, |log2FC| ≥ 1), indicating that RFI is closely associated with protein and lipid metabolism. Integrated analysis identified candidate biomarkers for low RFI individuals selection, including genes such as ACSM5, AHSG, CTRB1, PLA2G1B, AMY2A, CPA1, CCKAR and metabolites including taurine, uridine, L-phenylalanine, D-glucose 6-phosphate and 5‑hydroxy-L-tryptophan. Overall, LRFI hens maintain production while achieving lower intake, potentially via reduced inflammation/oxidative stress and enhanced digestion, barrier integrity, appetite, and energy metabolism, offering targets for marker-assisted improvement of feed efficiency in local breeds. - Source: PubMed
Publication date: 2025/09/27
Li JialeLi ShengheZhuansun MengmengLiu XinyuJin TaoYang KefengRen ManJin ErhuiLi XiaojinJin MengmengZhao Chunfang