Ask about this productRelated genes to: ALDH3A1 antibody
- Gene:
- ALDH3A1 NIH gene
- Name:
- aldehyde dehydrogenase 3 family member A1
- Previous symbol:
- ALDH3
- Synonyms:
- -
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2015-11-18
Related products to: ALDH3A1 antibody
Related articles to: ALDH3A1 antibody
- Breast cancer (BRCA) is a major health threat to women and often carries a poor prognosis. Succinylation is closely associated with cancer metabolism; however, research on succinylation-related genes (SRGs) in BRCA remains relatively limited. This study first identified differentially expressed genes between normal and BRCA groups in the TCGA cohort and intersected them with known SRGs to obtain differentially expressed SRGs (DE-SRGs). Univariate Cox and LASSO Cox regression analyses were used to screen the DE-SRGs, followed by multivariate Cox regression to develop a succinylation-related prognostic model. Subsequently, patients were categorized into high and low succinylation-related risk score (SRS) groups according to the median score. Two groups were then compared for differences in immune microenvironment characteristics, somatic mutation burden, and drug sensitivity. Additionally, the expression levels of the signature genes were validated via qRT-PCR. This study developed a prognostic risk model for BRCA patients based on 13 SRGs (ACOT4, ALDH3A1, B3GALT1, IFNG, MMP1, NFKB2, PCSK6, PTK2, SERPINA1, SHMT2, SIRT7, ST3GAL1, and SUCLA2). A markedly elevated infiltration of immune cells was observed in the low-SRS group, including B cells, Mast cells, and Macrophages. The tumor mutational burden was notably lower in the low-SRS group. Drug sensitivity analysis suggested that the high-SRS BRCA patients might be more susceptible to FTI-277 and GNF-2. qRT‑PCR results showed that ACOT4, IFNG, MMP1, NFKB2, PCSK6, PTK2, SHMT2, SIRT7, and ST3GAL1 were significantly upregulated in human BRCA cell lines, while ALDH3A1, B3GALT1, and SUCLA2 were significantly downregulated. Our findings highlight the prognostic value of SRGs in BRCA, laying the groundwork for its potential use in guiding personalized treatment. - Source: PubMed
Publication date: 2026/07/17
Chen ZhifengHu Mi - Keratocyte cells residing in the corneal stroma produce extracellular matrix (ECM) proteins and support transparency. These cells are pivotal for corneal regeneration and the development of in vitro tissue substitutes. However, there is limited literature on the characteristics of primary and immortalized keratocyte cells. - Source: PubMed
Publication date: 2026/07/14
Sahin Sevilay BurcuVural Ece TuranCetinel Sibel - Metabolic reprogramming represents a hallmark feature of hepatocellular carcinoma (HCC). As a crucial branch of the polyol pathway, the biological functions and clinical implications of sorbitol metabolism in HCC progression remain to be fully elucidated. - Source: PubMed
Publication date: 2026/07/07
Yang XianchunCheng YiJiang XingLi YinyuJiang ShuoYang JieLi ChaorongWu Lichun - Salivary aldehyde dehydrogenases (ALDHs), particularly ALDH3A1, are increasingly recognized as potential contributors to oral defense against aldehyde-associated stress at the oral-environment interface. Unlike freely secreted salivary enzymes, measurable salivary ALDH activity primarily reflects intracellular and vesicle-associated enzymes derived from salivary gland epithelial cells, oral mucosal cells, immune cells, and exfoliated cellular components. Within the oral exposome, ALDHs expressed in oral epithelial and salivary gland tissues participate in the detoxification of reactive aldehydes, while salivary ALDH activity may serve as an indicator of local aldehyde-detoxification capacity and tissue redox status. Beyond aldehyde metabolism, emerging evidence suggests that ALDH-associated pathways are linked to redox regulation, epithelial stress adaptation, inflammatory signaling, and tissue repair through NAD(P)-dependent processes and stress-responsive networks such as Nrf2 and SIRT1. This review provides a saliva-focused synthesis of ALDH biology, emphasizing isoform-specific functions and the potential importance of ALDH3A1 in oral epithelial defense. Altered salivary ALDH activity has been reported in association with oral conditions including periodontitis, oral lichen planus, radiation-induced salivary dysfunction, and oral squamous cell carcinoma (OSCC). Genetic factors, particularly ALDH2 polymorphisms, together with environmental exposures and microbial dysbiosis, may further influence aldehyde burden and oral disease susceptibility. Although current evidence supports the biological relevance of salivary ALDHs, their utility as clinical biomarkers or therapeutic targets remains investigational and requires further mechanistic and clinical validation. - Source: PubMed
Publication date: 2026/06/14
Khan Masood AlamYounus Hina - Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degeneration, chronic inflammation, and oxidative stress-induced mitochondrial dysfunction. Herein, we engineered an integrated therapeutic platform by encapsulating mesenchymal stem cell-derived exosomes (Exo) and manganese dioxide (MnO) nanozymes into methacrylated hyaluronic acid (HAMA) hydrogel microspheres (HAMA-Exo-MnO) via microfluidic fabrication. Systematic in vitro and in vivo evaluations assessed the microspheres' anti-inflammatory, antioxidant, and chondrogenic regenerative properties. In vitro experiments demonstrated that HAMA-Exo-MnO microspheres effectively attenuated OA-like pathological changes in chondrocytes, remodeled the inflammatory microenvironment, and scavenged reactive oxygen species (ROS). In a rat OA model induced by destabilization of the medial meniscus (DMM), intra-articular injection of HAMA-Exo-MnO microspheres ameliorated disease progression, enhanced articular cartilage regeneration, and restored joint function. Transcriptomic sequencing and subsequent validation in cocultured OA chondrocytes revealed significant upregulation of ALDH3A1, which mitigated oxidative stress, activated the NRF2 signaling axis, promoted downstream antioxidant gene expression, and restored mitochondrial electron transport chain activity. In summary, this study highlights that the engineered HAMA hydrogel microspheres provide a multifunctional therapeutic strategy for OA treatment, integrating immune microenvironment modulation, cartilage regeneration, and antioxidant protection. - Source: PubMed
Publication date: 2026/05/29
Teng JianxiangPan JiazhaoYan PengchengZhou TianqiZou ZihaoShu XiaolinLiu HaoZhang ZhuoranZhou ShengChen QiuhanShen DandanZhao XingTian XiaobinYang Long