Ask about this productRelated genes to: AGPAT5 antibody
- Gene:
- AGPAT5 NIH gene
- Name:
- 1-acylglycerol-3-phosphate O-acyltransferase 5
- Previous symbol:
- -
- Synonyms:
- FLJ11210, LPAAT-e, LPAAT-epsilon
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-12-03
- Date modifiied:
- 2019-03-26
Related products to: AGPAT5 antibody
Related articles to: AGPAT5 antibody
- The silkworm () is an economically important insect that plays a crucial role in agricultural development. Antimony tin oxide, a high-tech multifunctional nanomaterial, is extensively utilized in contemporary industries due to its properties of transparency, conductivity, and stability. Nevertheless, the toxicity and potential adverse effects of antimony tin oxide on living organisms remain poorly understood. In this study, we evaluated the effects of antimony tin oxide at varying concentrations (0-3.2 μg/μL) on the growth, oxidative stress response, gene expression, and midgut integrity of fifth-instar silkworm larvae. Exposure to high concentrations of antimony tin oxide resulted in a significant reduction in larval weight and severely disrupted the antioxidant defense system. RNA sequencing (RNA-Seq) analysis identified 239 differentially expressed genes (DEGs), which were confirmed by qPCR, revealing up-regulated lipid synthesis gene , down-regulated chitin degradation gene , and suppressed glycerolipid hydrolysis gene . Histopathological and ultrastructural examinations revealed severe damage to the structure of midgut epithelial cells. Structural and functional analysis of conserved domains in key DEG-encoded proteins revealed that gene dysregulation disrupted energy metabolism and compromised the physical barrier, ultimately linking molecular abnormalities to observed tissue damage. These findings elucidate the mechanisms by which antimony tin oxide induces midgut toxicity through interference with critical metabolic pathways and functional perturbations at the molecular level. - Source: PubMed
Publication date: 2026/03/22
Fang YangLi XuanZhang FengchaoLiu YangMa LiangChen LipingXie Qijun - To investigate the molecular targets and signaling pathways involved in the therapeutic effects of Lishukang Capsule (LSK) in a rat model of high-altitude pulmonary edema (HAPE) using a proteomics-based approach. - Source: PubMed
Zhang DongmeiYang ChenyuLi XiaolinShao JieLi WenbinWang Rong - This study aims to characterize tissue-specific expression patterns in Hanwoo steers by identifying co-expression modules, functional pathways, and hub genes related to fat and muscle traits using Weighted Gene Co-expression Network analysis (WGCNA). RNA-Seq data were generated from three muscle tissues (longissimus muscle, tenderloin, and rump) and two fat tissues (back fat and abdominal fat) collected from six 30-month-old Hanwoo steers. Quality control of raw sequencing reads was performed using FastQC, and trimmed reads were aligned to the bovine reference genome (ARS-UCD1.3) using HISAT2. We also identified a gene co-expression network via using normalized gene expression values. Modules were defined based on topological overlap and correlated with tissue-specific expression patterns. Modules with a significant association ( < 0.05) were used for functional enrichment based on Gene Ontology (GO) and KEGG pathways, as well as Protein-Protein Interaction Network analysis. A total of seven co-expression modules were identified by WGCNA and labeled in distinct colors (yellow, blue, red, brown, turquoise, green, black). Among them, the yellow and blue modules were positively associated with back fat, while the turquoise and green modules showed a negative correlation with abdominal fat. Additionally, the turquoise or green module was positively correlated with longissimus and rump tissues, indicating distinct gene expression patterns between fat and muscle. This study identified key co-expression modules and hub genes associated with muscle and fat metabolism. Notably, (blue module) was involved in lipid metabolism and energy storage, whereas (turquoise module) was linked to maintaining muscle cell structure and function. These findings reveal biological mechanisms for tissue-specific gene regulation, providing targets for enhancing meat quality in Hanwoo. - Source: PubMed
Publication date: 2025/11/03
Hwang SukJeong TaejoonLee JunyoungPark WoncheoulJang SunsikLim Dajeong - Hepatocellular carcinoma (HCC) has a poor prognosis due to late diagnosis and rapid progression, highlighting the need for a deeper understanding of its pathogenesis. Lysine crotonylation (Kcr), a unique post-translational modification, plays a crucial role in epigenetic regulation. However, the role of crotonylation-related genes (CRGs) in HCC remains poorly understood, necessitating an investigation of their prognostic and therapeutic relevance. - Source: PubMed
Publication date: 2025/06/13
Su WeipingKang KuoLi XuanxuanHuang Heyuan - Hepatocellular carcinoma (HCC) is a common and highly lethal malignant tumor that poses a serious threat to human health. The post-transcriptional modification of proteins known as butyrylation has emerged as a critical factor in tumorigenesis, playing a pivotal role in the initiation and progression of cancer. This study aimed to develop a prognostic risk model for HCC using butyrylation-related genes (BRGs). Differentially expressed BRGs were identified from the LIHC-TCGA data sets, and a prognostic risk model was constructed using LASSO and multivariate regression analysis. The model's robustness was further confirmed in the GSE14520 cohort. The clinicopathological characteristics, immune features, enrichment pathways, and antitumor drug sensitivity of the BRG signature were also assessed. Additionally, a nomogram was created to improve the predictive accuracy of the model. A set of 16 BRGs, including MMP1, ACOT7, AGPAT5, FLAD1, PDSS1, HSPD1, FKBP1A, AKR1B10, HDAC1, HDAC2, MAPT, ACADS, ACAT1, ACSL6, PDE2A, and PON1, were identified. Kaplan-Meier survival analysis showed that patients in the high-risk group had worse overall survival (OS) and progression-free survival (PFS) compared with those in the low-risk group. Univariate and multivariate Cox regressions, along with LASSO analysis, consistently indicated that the BRG signature is an independent prognostic factor for HCC. Clinical line plots accurately predicted 1, 3, and 5 year survival with AUC values of 0.805, 0.729, and 0.710, respectively. Additionally, the distribution of immune cells varied between different risk groups, and the low-risk group showed more potential for immunotherapy and chemotherapy. This study provides a novel biological basis for prognostic prediction in HCC and offers insights into personalized treatment strategies, including candidate drug selection, for clinicians to guide therapeutic decisions. - Source: PubMed
Publication date: 2025/01/18
Su WeipingZhou YangyingLi XuanxuanKang KuoNie Hui