Ask about this productRelated genes to: ADH1B antibody
- Gene:
- ADH1B NIH gene
- Name:
- alcohol dehydrogenase 1B (class I), beta polypeptide
- Previous symbol:
- ADH2
- Synonyms:
- -
- Chromosome:
- 4q23
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-01-18
Related products to: ADH1B antibody
Related articles to: ADH1B antibody
- Colorectal cancer (CRC) is one of the most commonly diagnosed and globally spread malignant diseases. Cancer-associated fibroblasts (CAFs) are key architects of the tumor microenvironment, yet their origin, stability, and interconvertibility remain poorly understood. Using transcriptomic profiling of fibroblasts from colorectal cancer (CRC) patients, we identify highly expressed (HEX) markers that define fibroblast subpopulations and uncover mechanisms governing their plasticity. We find that ADH1B marks normal colon-associated fibroblasts (NAFs), which consist of PI16-NAFs and ADAMDEC1-NAFs. ITGA3 delineates the total CAF population, which comprises myofibroblastic CAFs (myCAFs), whose characterizing markers were associated with poor prognosis and proteolytic inflammatory CAFs (piCAFs), characterized by markers not associated with prognosis. An AGT/TGM2-expressing fibroblast subset is present in both healthy and tumor tissues, suggesting alternative trajectories to the classical NAF-to-CAF transition model. While PI16-NAFs, AGT/TGM2-fibroblasts, and myCAFs maintain stable identities in long-term culture, the ADAMDEC1-NAF and piCAF phenotypes are lost in vitro. ITGA3-CAFs demonstrate dynamic plasticity, with TGF-β stably inducing myCAF formation and TNF-α or inhibition of DNA methylation promoting transient piCAF emergence. These findings redefine fibroblast heterogeneity in CRC and reveal a coexisting stable and plastic fibroblast network that may be amenable to modulation and provides a framework for future functional and translational studies. We identified highly expressed markers (HEX markers) to distinguish CAFs, NAFs and corresponding subpopulations in CRC. ADH1B characterized NAFs, which consisted of stable (solid outline) PI16-NAFs and unstable (dashed outline) ADAMDEC1-NAFs. ITGA3 identified CAFs consisting of stable myCAFs associated with poor prognosis and unstable piCAFs not associated with prognosis. AGT/TGM2 fibroblasts did not express ADH1B or ITGA3, were stable in culture and could be detected in both healthy colon and CRC. Treatment of PI16-NAFs with LPS or IFN-γ induced ADAMDEC1-NAFs, TGF-β the formation of myCAFs, while treatment with TNF-α led to the formation of piCAFs. Reduced DNA methylation converted myCAFs and PI16-NAFs into piCAFs. - Source: PubMed
Publication date: 2026/04/28
Demmler RichardAnchang Charles GYong YongsongRamming AndreasRauber SimonSchellerer Vera SSchmid BenjaminHartmann ArndtMerkel SusanneImkeller KatharinaNaschberger ElisabethStürzl Michael - To investigate the associations between alcohol intake and risks of chronic obstructive pulmonary disease (COPD) using self-reported alcohol intake and genetically predicted mean alcohol intake in adults in 10 areas of China. This study used baseline data collected in 2004-2008 from the China Kadoorie Biobank, and the COPD outcome was determined through long-term follow-up. After excluding participants with cancer, coronary heart disease, stroke or transient ischemic attack, asthma, tuberculosis, or COPD at baseline, 445 523 participants were included in the observational analysis. A total of 133 168 participants with complete genotyping data were included in the genetic analysis, after the same exclusion criteria were applied. Alcohol consumption patterns were obtained through a baseline questionnaire. The mean alcohol intake of male non-abstainers was calculated based on the combination of -rs671 and -rs1229984 genotypes and the study region, and all participants were divided into six groups (C1-C6) accordingly. Cox proportional hazards regression models were used to estimate the associations between exposure factors and risk of incident COPD. In the observational analysis, 11 825 incident cases of COPD were identified during an average follow-up period of (11.8±2.1) years. After adjusting for potential confounders, occasional and current drinking was associated with lower risk of incident COPD in males, with s (95%s) of 0.80 (0.74-0.86), 0.75 (0.68-0.83), 0.84 (0.76-0.93), 0.86 (0.76-0.97) and 0.84 (0.75-0.94) for occasional and current drinkers consuming pure alcohol <140.0, 140.0-, 280.0-, ≥420.0 g/week respectively, while there was no significant association between abstainers and risk of COPD. In females, compared with non-drinkers, the risk of COPD reduced in all groups except for current drinkers consuming pure alcohol 70.0-139.9 g/week, with s (95%s) of 0.81 (0.68-0.96), 0.87 (0.82-0.93), 0.78 (0.62-0.99) and 0.77 (0.62-0.96) for abstainers, occasional and current drinkers consuming pure alcohol <70.0, 70.0-, ≥140.0 g/week respectively. In the genetic analysis, the risk of COPD in the C2-C6 groups was similar to that of males in the C1 group. In females, only the C4 group had a lower COPD risk compared to the C1 group (=0.79, 95% : 0.63-0.99). The study does not support a causal association between alcohol consumption and the risk of COPD. - Source: PubMed
Zeng Z QWen Q RSun D J YPei PGuo YDu H DChen J SChen Z MLyu JLi L MYu C Q - Three functional single nucleotide variants (SNVs)‒ALDH2 rs671 (p.E504K), ADH1C rs698 (p.I350V), and ADH1B rs1229984 (p.R48H)‒are key genetic determinants of human alcohol metabolism. These variants significantly affect drinking behavior and are associated with liver disease and increased risks of several malignancies, including esophageal and gastric cancers. We developed a triplex fluorescent probe-based melting curve analysis (FMCA) assay for the simultaneous detection of these three SNVs. The assay was validated by comparing FMCA results with Sanger sequencing using genomic DNA from 94 Japanese individuals. The automated detection algorithm reliably identified genotypes of rs671 and rs698. Although the melting peaks of rs1229984 exhibited lower resolution and necessitated manual visual inspection for definitive genotype discrimination, all genotypes were nevertheless correctly identified. The assay demonstrated 100% accuracy. In conclusion, this triplex FMCA assay provides a rapid, cost-effective, and streamlined method for the simultaneous genotyping of ADH1B, ADH1C, and ALDH2. Given its high accuracy and ease of implementation, this method serves as a practical alternative to conventional sequencing, positioning it as a valuable tool for both large-scale epidemiological research and routine clinical assessment of alcohol-related health risks. - Source: PubMed
Publication date: 2026/03/31
Soejima MikikoKoda Yoshiro - The burden of chronic liver disease (CLD) is increasing. This study aims to identify protein markers for CLD and its progression, and develop a protein-based risk prediction model. - Source: PubMed
Publication date: 2026/03/26
Li XinxuanSun JingZhao JianhuiJiang FangyuanZhang MengWu HaoYuan ShuaiLi XueLu JuanMantzoros Christos S - Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, largely because of challenges in early diagnosis and the limited sensitivity of conventional biomarkers. Therefore, reliable molecular tools for early detection, prognostic stratification, and individualized treatment predictions are urgently required. - Source: PubMed
Publication date: 2026/03/04
Nguyen Tan ThinhNguyen Thanh DatNguyen Phu Qui LeBui Phuong ThiNguyen Minh Nam