Ask about this productRelated genes to: ACO2 antibody
- Gene:
- ACO2 NIH gene
- Name:
- aconitase 2
- Previous symbol:
- -
- Synonyms:
- ACONM
- Chromosome:
- 22q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2015-12-01
Related products to: ACO2 antibody
Related articles to: ACO2 antibody
- Clear cell renal cell carcinoma (ccRCC) represents one of the most prevalent malignancies worldwide, characterized by high incidence and mortality rates. It is characterized by mitochondrial dysfunction with enhanced Warburg effect. In this study, we identify the sortilin-related receptor 1 (SORL1) as a regulator of ccRCC progression and a potential molecular target for oxidative phosphorylation inhibition. The present evidence demonstrates that SORL1 promotes the ubiquitin-mediated degradation of C-MYC via TRIM22, which is associated with the downregulation of ACO2 and IDH2 and a consequent suppression of oxidative phosphorylation capacity. Molecular investigations further indicated that Cefoperazone could bind to SORL1 and increase its protein level, exerting the SORL1-triggering function. Targeting delivery Cefoperazone exhibits unexpected anti-tumor performances in ccRCC. Collectively, our findings establish SORL1 as a tumor suppressor in ccRCC and highlight its potential as a therapeutic target in advancing ccRCC clinical treatment strategies. - Source: PubMed
Publication date: 2026/09/04
Wang KeyiSong WeiBai QiShen ShaozeLu XiaoSu ChenxuanYang ShiWang YidiXia YuZan RuiJiang ShuaiGuo Jianming - Mitohormesis, whereby transient mitochondrial stress induces adaptive signaling, promotes organismal resilience and longevity in invertebrates, but how this operates in mammals and the underlying metabolic signals involved remain unclear. Using a mouse model of mitohormesis, we show that transient mitochondrial superoxide stress during embryogenesis reprograms the adult heart to enhance mitochondrial biogenesis and antioxidant capacity. These adaptations confer protection against mitochondrial and oxidative injury in models of doxorubicin-induced cardiotoxicity, preserving mitochondrial content and preventing cardiac dysfunction and remodeling. Using a cell model of superoxide-mediated mitohormesis, we find that inhibition of mitochondrial aconitase promotes citrate export to the cytosol, where its conversion to acetyl-coenzyme A drives histone acetylation and mitohormetic protection from oxidative stress. Preventing mitochondrial citrate export abolishes these adaptations, while silencing or citrate supplementation recapitulates the response. Together, our findings identify mitochondrial citrate as a redox-sensitive second messenger linking mitochondrial superoxide stress to durable epigenetic and mitohormetic remodeling. - Source: PubMed
Publication date: 2026/09/04
Donnelly Matthew PMangalhara Kailash ChandraLiu YueningLande KathrynRojas Gladys RGrae Kym JReynolds Mack BGhosh SagnikaOlliffe NevaEsparza-Moltó Pau BJohnson Melissa ADufresne SuzanneLouie Allison YMoyzis Alexandra GGuan DeannGustafsson Åsa BG Towers ChristinaKosuri PallavMetallo Christian MHargreaves Diana CShadel Gerald S - The early developmental stages of fish exhibit the highest mortality and greatest environmental sensitivity throughout their life cycle. This period encompasses a series of crucial biological events, including morphogenesis, organ differentiation, and nutritional mode transition from fertilized eggs to newly hatched larvae. Although largemouth bass (Micropterus nigricans) is a commercially important fish species in China, the molecular regulatory mechanisms governing its endogenous nutritional stage remain largely unexplored. To elucidate the molecular basis of this critical period, we performed transcriptomic profiling across six consecutive developmental stages (Multicellular, Blastula, Gastrula, Neurula, Organogenesis, and 5 day post hatching larvae). Our results reveal stage-specific transcriptional programs: the multicellular-to-blastula transition is characterized by stage-specific enrichment of by cell cycle and DNA replication pathways, with MCM complex (mcm2-5) upregulation accelerating proliferation; the blastula-to-gastrula transition features activation of bmp4, fgfr2, and lft1 for germ layer induction; the neurula stage exhibits transcriptional bursts and enrichment of neural tube-related pathways; organogenesis involves simultaneous activation of focal adhesion (col1a1b, col4a5, tnc) and Wnt signaling (wnt1, wnt4, wnt3a) pathway; and 5 dph larvae show visual function maturation, with light transduction genes (gnat1, gnat2, gucy2f, pde6b) identified as hub genes. Mfuzz analysis further reveals sustained upregulation of Cluster 14 (igf2r、napin、vamp7、il1b、aco2) indicating functional maturation, while Cluster 29 (mcm10, espl1, cep152, cep44, cep295) confirms declining cell division activity. Collectively, this study provides a transcriptomic resource for understanding largemouth bass embryonic development and offers molecular insights for improving hatchery practices. - Source: PubMed
Publication date: 2026/08/31
Hua JixiangTao YifanSun HuiZhu TaideWang XiaoyiHuang XiaochenWang WenLu SiqiLu JianQiang Jun - Future wheat-growing environments are exepected to be warmer, drier, and characterised by elevated atmospheric CO2 concentration (eCO2). While drought and elevated temperature (eT) generally reduce yield, eCO2 can partially offset these effects, although responses vary among genotypes. Identifying genotypes suited to future climates is therefore critical, yet large-scale screening under eCO2 remains constrained by the high cost and availability of specialised facilities. An alternative approach is to determine whether genotype performance under ambient conditions can predict responses under combined future climate conditions. However, the robustness of such predictive relationships under interacting environmental drivers remains unclear. - Source: PubMed
Publication date: 2026/08/27
Ripley B SSingini E JMavindidza PMutengwa C S - Major depressive disorder (MDD) and problematic alcohol use (ALC) commonly co-occur, yet the extent, genomic distribution, and biological context of their shared genetic architecture remain incompletely understood. Here, we integrated genome-wide and local genetic architecture analyses with tissue, spatial, single-cell, and multi-omics analyses to characterize the shared genetic basis of MDD and ALC. Across methods, the two phenotypes showed a consistent positive genetic correlation (r = 0.380-0.582). MiXeR estimated that they shared approximately 5479 variants with non-zero additive genetic effects, with the shared component accounting for a larger proportion of the polygenic architecture of ALC than of MDD. Local analyses further indicated that shared genetic covariance was concentrated in a limited number of genomic segments. At the tissue and cellular levels, genetic signals were primarily associated with central nervous system tissues and neuronal lineages, with additional support for oligodendrocyte-related populations; the two phenotypes also differed in the distribution and within-cell-type heterogeneity of disease-relevance scores. Multi-omics integration prioritized MED19 and ACO2 as candidate genes and highlighted processes related to mitochondrial energy metabolism and synaptic function. These findings refine the genomic, tissue, and cellular context of the shared genetic architecture of MDD and ALC and provide prioritized genomic regions, cell types, and candidate genes for validation in independent populations and functional studies. - Source: PubMed
Publication date: 2026/08/27
Chen GuangleiZhu XingChu CancanQin ZhongChen Yunzhi