Ask about this productRelated genes to: ApoA1 antibody
- Gene:
- APOA1 NIH gene
- Name:
- apolipoprotein A1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: ApoA1 antibody
Related articles to: ApoA1 antibody
- Hypertensive disorders of pregnancy (HDP) are one of the leading causes of maternal morbidity and death. There is an urgent need to improve early identification of women at risk of HDP, and assessment of pregestational cardiometabolic biomarkers is a potential way forward. - Source: PubMed
Publication date: 2026/04/01
Qvick AngelikaSandström AnnaNorhammar AnnaVikström MaxSpetz Holm Anna-ClaraHultgren RebeckaHammar NiklasLeander Karin - Patients who undergo percutaneous coronary intervention (PCI) remain exposed to residual lipid and inflammatory risk despite contemporary secondary prevention. Real-world longitudinal data describing how conventional lipids, apolipoproteins, small dense low-density lipoprotein (sdLDL), lipoprotein(a) [Lp(a)], and C-reactive protein (CRP) remodel together after PCI are limited. We evaluated serial post-PCI changes in a broad atherosclerotic biomarker panel and explored the dissociation between cholesterol control and inflammatory control. - Source: PubMed
Publication date: 2026/04/30
Wang AnChen ShuaiWang JianyuYin XiangyangDu ChaoyangDing Fenghua - Plasma concentration of high-density lipoprotein cholesterol (HDL) is among the most important risk factors for coronary artery disease and apolipoprotein A1 (APOA1) is an essential apolipoprotein that constitutes HDL. However, few comprehensive searches have been conducted to identify non-coding functional SNPs around the APOA1 gene. In this study, we report the identification of a functional SNP, rs12718466, which influences hepatocyte-specific APOA1 gene expression. Furthermore, we identified SOX7 as the transcription factor interacting with the rs12718466 SNP, using a novel screening method Transcription Factor Expression Library (TFEL) scan, which employs a comprehensive library of mouse transcription factors. SOX7 binding is allele-dependent, with stronger binding to the normal allele leading to increased APOA1 transcription. In vitro experiments in hepatocytes and in vivo experiments in mice confirmed that overexpressing SOX7 increased APOA1 expression, while knocking it down decreased both APOA1 gene expression and plasma HDL-C levels. Our research demonstrates that rs12718466 is a functional SNP that modulates APOA1 gene expression through its interaction with SOX7, thereby affecting plasma HDL-C concentrations. - Source: PubMed
Publication date: 2026/04/27
Aita YuichiTakeuchi YoshinoriMasuda YukariMehrazad Saber ZahraKarkoutly SamiaTao DuhanYe ChenMendsaikhan TsolmonSaikawa RikaKondo YasuyukiMurayama YukiShikama AkitoMatsuzaka TakashiShimano HitoshiKawakami YasushiYahagi Naoya - Early-stage lung adenocarcinoma (LUAD) in never smokers exhibits distinct biological features, yet the metabolic programs driving early invasion remain unclear. We integrate proteomic and lipidomic profiling of primary LUAD tumors from never smokers, matched normal adjacent tissues (NATs), and benign pulmonary nodules (BPNs). Integrated multi-omics analysis reveals coordinated dysregulation of lipid metabolism and immune signaling in early LUAD. Proteome-based network fusion stratifies invasive LUAD into immune-metabolic synergistic (IMS) and metabolic-stress-driven (MSD) subtypes. IMS tumors retain apolipoprotein-associated lipid modules and favorable immune features, whereas MSD tumors exhibit stress-response programs. Mechanistically, APOA1 and APOC1 emerge as key nodes linking lipid homeostasis to invasion, and their depletion promotes LUAD cell migration and invasion. We establish a two-protein, four-lipid diagnostic panel demonstrating robust performance across tissue and plasma cohorts. These findings provide a molecular basis for early detection and risk stratification in never smokers. - Source: PubMed
Publication date: 2026/04/28
Sun YaohuiLiu JianXu XinLiu QiqiCheng HuaHuo WenwenWang RonghaoCao Qingdong - The significance of cholesterol efflux as a predictor of coronary artery disease (CAD) remains controversial. The intracellular cholesterol export via the ABCA1 transporter involves the acceptance of cholesterol by both lipid-free apolipoprotein A-I and high-density lipoproteins (HDL). An estimate of the efficiencies of two reactions is thus required. - Source: PubMed
Baserova Veronika BPopov Mikhail ADergunov Alexander D