Ask about this productRelated genes to: Tgfb3 Blocking Peptide
- Gene:
- TGFB3 NIH gene
- Name:
- transforming growth factor beta 3
- Previous symbol:
- ARVD1, ARVD
- Synonyms:
- -
- Chromosome:
- 14q24
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-10
- Date modifiied:
- 2019-04-23
Related products to: Tgfb3 Blocking Peptide
Related articles to: Tgfb3 Blocking Peptide
- Many transcription factors may be involved in the pathogenesis of pulmonary fibrosis (PF). One such factor is PPARG. The PPARG agonist, pioglitazone (PG), has demonstrated general lung protective activity in animal models and is considered a promising therapeutic agent for fibrotic intervention. This study aimed to investigate the effect of PG on the expression of connective tissue remodeling genes in the lungs using bleomycin (BLM)-induced lung fibrosis (BIF). - Source: PubMed
Publication date: 2026/05/04
Kabaliei AlinaPalchyk VitalinaIzmailova OlgaShynkevych ViktoriyaShlykova OksanaKaidashev Igor - Systemic sclerosis (SSc) is a multi-organ autoimmune disease characterized by fibrosis of the skin and internal organs. Interstitial lung disease (ILD) is a major complication and leading cause of mortality in SSc. Transforming growth factor-β (TGF-β) has been implicated as a central mediator of fibrosis; however, while TGF-β1 has been extensively studied, the roles of TGF-β2 and TGF-β3 remain incompletely defined. Here, we systematically compared the effects of TGF-β1, TGF-β2, and TGF-β3 in dermal and lung fibroblasts, evaluating extracellular matrix synthesis and contraction, cytokine secretion, proliferation, and myofibroblast differentiation. TGF-β2 and TGF-β3 induced greater profibrotic cytokine release of Interleukin (IL)-6 and IL-11 and increased collagen-I and fibronectin synthesis compared with TGF-β1 in dermal and lung fibroblasts (all < 0.05). TGF-β2 and TGF-β3 stimulated greater collagen-I contraction in dermal fibroblasts ( < 0.05), but greater myofibroblast differentiation in lung fibroblasts ( < 0.05). The TGF-β isoforms did not affect proliferation. All TGF-β isoforms activated SMAD2/3 signalling; however, TGF-β2 and TGF-β3 reduced expression of TGF-β Receptor II and the inhibitory regulator, SMAD7. In summary, TGF-β2 and TGF-β3 have a more pronounced profibrotic effect than TGF-β1 on dermal and lung fibroblast functions, making them potential targets for treatment for skin and lung fibrosis in diseases such as SSc. - Source: PubMed
Publication date: 2026/04/10
Badyal RaveenKohlen BrandonKeen Kevin JDunne James VHackett Tillie-Louise - - Source: PubMed
Publication date: 2026/04/24
- To investigate the intraocular distribution and correlation of transforming growth factor-β isoforms and growth differentiation factor-15 in paired aqueous humor and undiluted vitreous samples from patients with various retinal diseases. - Source: PubMed
Publication date: 2026/04/22
Mieno HirokiHashida MasatsuguYoshii KengoHorikiri TomokoUrabe KimiakiMori KazuhikoUeno MorioSotozono Chie - Intervertebral disc degeneration (IVDD) is characterized by progressive nucleus pulposus cell loss and extracellular matrix degradation, in which persistent oxidative stress plays a critical pathogenic role. Transplantation of nucleus pulposus-derived stem cells (NPSCs) is a promising therapeutic strategy, yet the hostile oxidative microenvironment severely compromises cell survival. Although cellular quiescence has been suggested to enhance stress tolerance, its regulatory mechanisms and relevance in NPSCs remain largely unexplored. - Source: PubMed
Publication date: 2026/04/20
Chen QiChen XiaolongYang QuMiao XinxinYuan JinghongDing ShuihuaDing RuiCai ShenghaoLi BinCheng Xigao