Ask about this productRelated genes to: DERL3 Blocking Peptide
- Gene:
- DERL3 NIH gene
- Name:
- derlin 3
- Previous symbol:
- C22orf14
- Synonyms:
- FLJ43842, MGC71803, derlin-3, IZP6
- Chromosome:
- 22q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-14
- Date modifiied:
- 2014-11-19
Related products to: DERL3 Blocking Peptide
Related articles to: DERL3 Blocking Peptide
- Metabolic dysfunction-associated steatohepatitis (MASH) is the most prevalent chronic liver disease worldwide; however, few effective therapeutic options are available for MASH. is a medicinal plant that has been widely utilized in traditional medicine to treat liver-related ailments. Nonetheless, the effects and underlying mechanisms of in the context of MASH remain poorly understood. - Source: PubMed
Publication date: 2026/04/15
Wang LinlinMiao YuWang HailongHasimu HamulatiJi TengfeiHuang HuaDu GuanhuaAisa Haji AkberXin Xuelei - (Derlin 3) is a Derlin family protein involved in endoplasmic reticulum (ER) associated degradation of unfolded or misfolded glycoproteins. Our previous comprehensive genomic and transcriptomic profiling of leukoplakia and oral squamous cell carcinoma (OSCC) revealed amplification at the 22q11.23 locus, which harbours the gene. However, mRNA expression was found to be downregulated during disease progression, suggesting the role of epigenetic regulation. - Source: PubMed
Publication date: 2026/03/13
Inchanalkar MayuriChavda RinalGawde JitendraPatil AsawariKaushal Rajiv KumarMahimkar Manoj B - Gliomas, particularly glioblastoma multiforme (GBM), represent the most prevalent primary intracranial malignancies, characterized by high invasiveness, aggressive proliferation, and poor clinical outcomes. Recent studies have highlighted the critical role of tumor microenvironment interactions and cellular stress responses, including endoplasmic reticulum (ER) stress, in modulating glioma progression. While ER stress can induce autophagy and apoptosis, glioma cells exhibit remarkable plasticity, adapting to stress conditions and exploiting them to promote survival and self-renewal, thereby contributing to therapeutic resistance. In this study, we established an individualized ER stress risk score using glioma transcriptomic data, demonstrating its association with adverse prognosis, aggressive molecular subtypes, and pro-tumorigenic biological functions. Through systematic screening, we identified DERL3 as a core effector gene mediating ER stress adaptation. Functional validation revealed that DERL3 drove glioma proliferation and invasion by binding to and stabilizing Heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), consequently activating the NF-κB signaling pathway. These findings elucidate the DERL3-HNRNPA2B1-NF-κB axis as a critical mechanistic link between ER stress adaptation and glioma malignancy. Targeting this axis may offer novel therapeutic strategies to overcome treatment resistance, providing significant translational potential for improving glioma management. This study advances our understanding of stress response mechanisms in tumorigenesis and underscores the clinical relevance of ER stress-related pathways in precision oncology. - Source: PubMed
Publication date: 2025/12/25
Du ShaoqiZhang ShuoLi ChenDu ShaonanGuan ShuWang ShiyangWang ZheDong TaoRen Xiaolin - This study aimed to investigate the role of integrated stress response (ISR)-related biomarkers in periodontitis (PD). - Source: PubMed
Publication date: 2025/12/11
Du LinlingPan JieXu NanYan FengTian WeiyiLi Qiyan - Skin cutaneous melanoma (SKCM) is a highly invasive cancer with dismal prognosis. Integrated stress response (ISR) is associated with tumorigenesis and progression, but its relationship with SKCM prognosis is unclear. This research aimed to identify relevant prognostic genes for SKCM prognosis and treatment insights. - Source: PubMed
Publication date: 2025/12/02
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