Ask about this productRelated genes to: TRAF6 Blocking Peptide
- Gene:
- TRAF6 NIH gene
- Name:
- TNF receptor associated factor 6
- Previous symbol:
- -
- Synonyms:
- RNF85
- Chromosome:
- 11p12
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-12
- Date modifiied:
- 2015-11-20
Related products to: TRAF6 Blocking Peptide
Related articles to: TRAF6 Blocking Peptide
- Protein kinase CK2 is a pleiotropic oncogenic serine/threonine kinase implicated in multiple cancer-associated signaling pathways. However, its role in shaping the tumor immune microenvironment (TIME) and regulating immune checkpoint stability remains incompletely understood. - Source: PubMed
Publication date: 2026/05/09
Zhang SijiaLuo LihuaQu YangangZong YanChen LeichongLi QianwenLi ZhenyuWang JianJie XiaohuaXia YunQu BinLi JunyuXu ChunweiZou BingwenZhuang HongqingMeng Rui - Periodontitis is a long-lasting inflammatory disorder of structures attached, which is significantly influenced by insufficient or dysregulated immune responses. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) are a promising therapeutic modality. This study explores the therapeutic efficacy of EVs derived from miR-146a-overexpressing bone marrow-derived mesenchymal stem cells (BMSCs) in a ligature-induced periodontitis model. - Source: PubMed
Publication date: 2026/05/09
Chu WenZhang YinuoShen ShiyingWang ZhiluGuo YanxuYu YanfangHuang DahaiDavtyan Nara - After myocardial infarction (MI), macrophage-mediated clearance of dead cells, a process known as efferocytosis, represents a pivotal role in tissue remodeling. Efficient efferocytosis contributes to rescuing neighboring viable cardiomyocytes, drives the phenotypic transition of reparative macrophages, and facilitates the resolution of inflammation. In this study, we explored the roles of CD40 and the signals transduced by its 2 downstream adaptor-protein binding sites (TRAF2/3/5 and TRAF6) in the cardiac macrophage efferocytosis after MI. - Source: PubMed
Publication date: 2026/05/07
Zhang LinlinChen YanshanXu PengPengZheng TaoSheng JieWang ZhiyueWang ShengDing YuLu JiaqiLiu XingjiWang CanbiaoZhang YunmingMa LongPan JingPu JunZhang Longjiang - The present study investigated the effects of daily dietary supplementation with Spirulina platensis powder at two inclusion levels (0.04 g and 0.08 g/kg body weight) for working dogs. Spirulina platensis is a nutrient-rich microalgae containing high-quality protein, vitamins, minerals, and antioxidant pigments. These constituents are reported to possess immunomodulatory, antioxidant, and gut health-promoting effects. Dose-dependent effects on nutritional status, metabolic profiles, antioxidant and inflammatory status, gut integrity, immune function, and systemic gut health-related nutrigenomic responses were assessed in working dogs. A total of 15 adult male German Shepherd working dogs (age 2-3 years, weight range 24-26.5 kg) were randomly assigned to 3 groups (n = 5) over a 7-week experimental period, with evaluations at weeks 0, 3, and 7. The groups were as follows: first group, control (CON), fed on a basal diet; the second group (SP1) fed on the basal diet plus 0.04 g/kg body weight/day Spirulina powder; the third group (SP2) fed on the basal diet plus 0.08 g/kg body weight /day Spirulina powder. - Source: PubMed
Publication date: 2026/05/06
Abdelhady Hala AYassin Aya MAboul-Ella HassanFahmy Khaled Nasr El-DinFarghali Haithem A MM A Tony - Levetiracetam (LTM) is a commonly used anti-epileptic medication, however its possible cardiovascular (CV) risks are poorly characterized. The present study aimed to investigate the dose-dependent cardiac toxicity induced by LTM in Sprague-Dawley (SD) rats through the assessment of inflammatory signaling, oxidative stress, apoptosis, functional impairment and structural damage. Thirty-six male albino SD rats were randomly distributed into four groups (n = 9) namely the control, LTM (25 mg/kg), LTM (50 mg/kg), and LTM (150 mg/kg). LTM administration significantly increased the expressions of toll-like receptor-4 (TLR4) signaling cascade, as indicated by significant upregulation of myeloid differentiation factor-88 (MyD88), interleukin-1 receptor-associated kinase-4 (IRAK4) and tumor necrosis factor receptor-associated factor-6 (TRAF6). Similarly, there was a paradoxical increase in the expression of nuclear factor kappa B inhibitor alpha (IκBα) in parallel with enhanced activation of nuclear factor-kappa B (NF-κB) which culminated in increased production of pro-inflammatory mediators such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 1 beta (IL-1β), and cyclooxygenase-2 (COX-2). Oxidative stress was marked, as shown by higher levels of reactive oxygen species (ROS), malondialdehyde (MDA) with inhibition of antioxidant enzymes such as heme oxygenase-1 (HO-1), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GSR) and glutathione-S-transferase (GST) following LTM exposure. LTM intoxication promoted the concentrations of serum creatine phosphokinase (CPK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), troponin I, troponin T, B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide NT proBNP and C-reactive protein (CRP) in a dose-dependent manner. Moreover, LTM intoxication altered echocardiographic parameters including reduced ejection fraction (EF), heart rate (HR), dilation of left ventricle, and increased ventricular diameter. The levels of Bcl-2 associated X protein (Bax), cysteine-aspartic proteases-3 (caspase-3) and cysteine-aspartic proteases-9 (caspase-9) were increased, accompanied by reduced levels of B-cell lymphoma-2 (Bcl-2) in response to all the tested doses of LTM. Collectively, these findings show that LTM induces cardiotoxicity through modulation of the TLR4/NF-κB-mediated inflammation, oxidative stress, and apoptosis in a dose-dependent manner. - Source: PubMed
Publication date: 2026/04/30
Alqahtani Mohammad YAlghamdi AbdullahAlghamdi Suad ABinshaya Abdulkarim SSafhi Awaji YSabei Fahad YAbalkhail AdilAlissa Mohammed