Ask about this productRelated genes to: RSAD2 Blocking Peptide
- Gene:
- RSAD2 NIH gene
- Name:
- radical S-adenosyl methionine domain containing 2
- Previous symbol:
- -
- Synonyms:
- cig5, viperin, vig1
- Chromosome:
- 2p25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-11-08
- Date modifiied:
- 2014-11-19
Related products to: RSAD2 Blocking Peptide
Related articles to: RSAD2 Blocking Peptide
- Transposable elements (TEs) are major contributors to genome plasticity and can reshape gene regulation through stress-responsive activation and the formation of TE-gene chimeric transcripts. Although therapeutic stress is known to perturb transcriptional networks in cancer cells, its impact on canonical TE transcription and TE-gene chimera formation in esophageal squamous cell carcinoma (ESCC) remains poorly defined. To address this, we performed a comprehensive transcriptome-wide analysis of TE expression and TE-gene chimeric transcripts in KYSE150 ESCC cells following combined 125I radiation and carfilzomib treatment. The TE analysis showed 148 dysregulated TEs, characterized by ERV1 LTR element enrichment and distinct treatment-control sample separation, indicating structured remodeling of the TE transcriptome. We identified 301 significant TE-gene chimeric events, indicating category-specific remodeling with an increase in TE-initiated and TE-exonic chimeras and a decrease in TE-terminal events. The TE families that underwent the most transcriptional changes were not those that drove chimeric events, indicating that global TE activation does not passively cause chimera remodeling. The gene repression was strongly associated with chimeric transcripts, and gene expression changes were negatively correlated with chimerism frequency. , , and , strongly downregulated genes, produced novel TE-derived isoforms and were high-potential functional candidates. Epigenetic context analysis showed considerable overlap between exonized chimeras and candidate cis-regulatory elements, suggesting a potential association with regulatory genomic contexts. Pathway enrichment analysis showed synchronized transcriptomic reprogramming and cell cycle and DNA repair pathway activation and autophagy inhibition. In esophageal cancer cells, concurrent genotoxic and proteotoxic stress causes complex TE remodeling, linking traditional TE transcriptional alterations to structured TE-gene chimera development and stress-related transcriptome reprogramming. - Source: PubMed
Publication date: 2026/04/13
Majid MuhammadMoeen MuhammadAmjad NoumanKhan HashimSun ZhaojianWu LinpingLi Zhiyuan - Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and hospitalization in infancy. Reliable biomarkers reflecting host antiviral responses and disease dynamics are still lacking. - Source: PubMed
Publication date: 2026/04/01
Galliano IlariaLiguori Stefania AlfonsinaPau AnnaMontanari PaolaCalvi CristinaClemente AnnaMassobrio AnnaLinari ClaudiaGambarino StefanoConio AlessandraBergallo Massimiliano - Bovine viral diarrhea virus (BVDV) strains of differing virulence are associated with distinct clinical and lymphoid outcomes, but transcriptional responses within peripheral lymphocyte compartments remain incompletely defined. Here, we performed RNA-seq on CD4/CD8β/TcR1 bead-enriched peripheral lymphocyte fractions from calves experimentally infected with low-virulence or high-virulence noncytopathic BVDV strains (BVDV2-RS886 and BVDV2-1373, respectively) and sampled on days 0, 3, and 15 days post-inoculation. Because group sizes were small (n = 3 per group), analyses were interpreted as exploratory. Marker-gene analyses indicated that the sequenced material represented a T-cell-enriched but compositionally heterogeneous peripheral lymphocyte fraction. At day 3, both infection groups showed strong induction of interferon-responsive genes, including OAS family members, ISG15, IFI44/IFI44L, RSAD2, DDX58, and ZBP1. The high-virulence group additionally showed broader reduction of transcripts associated with lymphocyte signaling, trafficking, and biosynthetic activity. By day 15, the low-virulence group showed only a small residual response, whereas the high-virulence group remained broadly perturbed, with reduced abundance of multiple adaptive immune and antigen-presentation-associated transcripts in the bead-enriched fraction. These data define divergent temporal transcriptomic trajectories associated with BVDV2 virulence and provide a hypothesis-generating resource for future studies using phenotypically defined bovine lymphocyte subsets. - Source: PubMed
Publication date: 2026/04/23
Bauermann Fernando VicosaBayles Darrell OFalkenberg Shollie MMaggioli Mayara FRidpath Julia F - This study evaluated the immunomodulatory effects of dietary β-glucan derived from the marine diatom Chaetoceros muelleri on immune responses and survival of Nile tilapia (Oreochromis niloticus) following Tilapia Lake Virus (TiLV) infection. Juvenile tilapias were fed diets supplemented with 0.1% or 0.2% β-glucan for 14 days prior to viral challenge. Fish were subsequently challenged with TiLV and immune-related gene expression was analysed in spleen and liver tissues. Fish fed the 0.1% β-glucan diet showed significantly lower cumulative mortality (26.67%) compared with the control group (55.56%) and the 0.2% group (42.22%). Dietary β-glucan significantly influenced the expression of multiple immune-related genes including cytolytic (NCCRP-1), stress-related gene (Hsp70), antimicrobial protein (C-lysozyme), cytokine (IL-8), pattern recognition receptors (TLR3, TLR5, TLR9), signalling adaptor (myD88), antiviral effector (Mx, RSAD-2), adaptive immunity (IgM, CD4). Correlation heatmap and gene co-expression network analyses revealed coordinated immune regulation, with Mx, RSAD-2 and CD4 acting as central hub genes associated with antiviral defence pathways. These results demonstrate that moderate dietary supplementation with C. muelleri-derived β-glucan enhances immune responses and improves resistance to TiLV infection in Nile tilapia, supporting its potential application as a functional feed additive in tilapia aquaculture. - Source: PubMed
Publication date: 2026/04/13
Madyod SulaimanPholmai SuwannaPrombanchong ThitikornLaksana-Aut PatcharaponUnajak SasimanasHirono IkuoWuthisuthimethavee Suwit - Type I interferon (IFN-I) responses are tightly regulated to balance antiviral defense with cellular homeostasis. In humans, interferon-stimulated gene 15 (ISG15) functions as a critical negative regulator of IFN-I signaling by stabilizing the IFN negative regulator USP18, yet the functional consequences of ISG15 deficiency remain elusive. Here, we show that the loss of ISG15 exaggerates the JAK-STAT activation and, downstream, amplifies multiple ISGs including the nucleotide-modifying enzyme RSAD2 (viperin). Our quantitative proteomics, genetic reconstitution, and signaling analyses establish that defective USP18 stabilization skews the IFN response towards viperin expression. This amplified ISG network promotes viperin-catalyzed accumulation of the antiviral nucleotide analog ddhCTP, resulting in enhanced inhibition of viral RNA synthesis and the replication of Crimean-Congo hemorrhagic fever virus and SARS-CoV-2. Together, these findings demonstrate an ISG15-USP18-viperin axis that can be targeted to boost the metabolic antiviral restriction. - Source: PubMed
Publication date: 2026/03/14
Kahler Niklas LRezene SefanitScholte Florine EmAmbikan Anoop TSaccon ElisaMonteil Vanessa MNaval PrajaktaMacmillan RobinFrick SimonNorén JennyLourda MagdaMirazimi AliBryceson Yenan TLira-Junior RonaldoPrasad VibhuVégvári ÁkosNeogi UjjwalBamford Connor GgHofer AndersBergeron EricPurhonen JanneGupta Soham