Ask about this productRelated genes to: BVES Blocking Peptide
- Gene:
- BVES NIH gene
- Name:
- blood vessel epicardial substance
- Previous symbol:
- -
- Synonyms:
- HBVES, POP1, POPDC1
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-10
- Date modifiied:
- 2015-08-24
Related products to: BVES Blocking Peptide
Related articles to: BVES Blocking Peptide
- - Source: PubMed
Publication date: 2026/04/15
Tan XiaoliLv XiaodongChen RuruXu YufenChen Wenyu - Although peptide-based delivery strategies show promise for muscle and heart diseases, delivery of biotherapeutics to both skeletal and cardiac muscles remains challenging. Here, we identified a muscle-homing peptide (BV2) against blood vessel epicardial substance (BVES) by phage display. BV2 shows high binding affinity to BVES and is internalized primarily via caveolae-mediated endocytosis. Importantly, BV2 enables efficient delivery of Duchenne Muscular Dystrophy (DMD) phosphorodiamidate morpholino oligomer (PMO), mCherry protein and exosomes to skeletal muscle and heart in vivo. BV2-mCherry protein and BV2-E31R anti-myostatin peptide were effectively delivered to muscle layers when microneedles loaded with these biotherapeutics were implanted on hindlimbs of mice. Muscle mass and myofiber size also significantly increased in muscle atrophy mice grafted with BV2-E31R microneedles. Moreover, significantly enhanced restoration of dystrophin protein was achieved in peripheral and cardiac muscles of dystrophin-deficient mdx and dystrophin/utrophin double-knockout mice when exosomes simultaneously modified with BV2 and PMO. These findings highlight the potency of BV2 in directing targeted delivery of diverse biotherapeutics to muscle and heart, thus providing an effective tool for DMD and other muscular and cardiac disorders. - Source: PubMed
Publication date: 2026/01/04
Wang BiaobiaoCao JiahuiWu JingqiaoZhao YiwenZhang YaoAbendroth FrankLin CaoruiZhong LiYu HuananSeow YiqiOu MeitongVázquez OlallaMei LinYin HaiFangHan Gang - (1) Background: The proliferation and differentiation of antler mesenchymal stem cells (MSCs) are vital for antler growth. Our group found that BVES is downregulated during peak antler growth but is highly expressed in mesenchymal tissues, suggesting its role in regulating antler homeostasis. (2) Methods: We manipulated BVES expression in antler MSCs using lentiviral plasmids and siRNA, and then assessed its effects on MSC proliferation via CCK-8 and EdU assays, while also analyzing changes in Wnt pathway gene expression. (3) Results: Overexpression of BVES significantly decreased the CCK-8 OD value of antler MSCs ( < 0.05), and EdU assays revealed a significantly lower cell positivity rate compared to the control group ( < 0.01). In contrast, suppression of BVES resulted in a significant increase in the OD value ( < 0.05) and a significantly higher cell positivity rate than the control group ( < 0.05). Additionally, overexpression of BVES significantly downregulated the expression of key Wnt signaling pathway genes (, , , ), while suppression of BVES led to their upregulation. (4) Conclusions: In summary, the gene inhibits the proliferation of antler MSCs by suppressing the Wnt signaling pathway. It may serve as a key gene in maintaining antler MSC homeostasis and regulating antler growth, providing a new perspective for understanding the mechanisms of antler growth. - Source: PubMed
Publication date: 2025/09/07
Chen HongLin ChuanXiang XinYang ChenchenHan ChunmeiGao Qinghua - Even though the enhanced permeability and retention (EPR) effect is applicable for the passive targeting of solid tumors, many nanodrugs have failed to achieve meaningful clinical outcomes due to the heterogeneity of EPR effect. Therefore, understanding the mechanism of the EPR effect is crucial to overcome the obstacles nanomedicines face in clinical translation. The aim of this study was to establish a reliable method to increase awareness of the critical influencing factors of nanoparticle (NP) transport into tumors based on the EPR effect using a combined radiogenomics and clinical magnetic resonance imaging (MRI) technique and gene set pathway enrichment analysis. Employing poly(lactic--glycolic acid) (PLGA)-coated FeO NPs as the contrast agent, the monolayer and multilayer distribution of the NPs were observed and quantitatively analyzed by MRI, improving the accuracy of evaluating vascular permeability by MRI. By performing Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of genes and pathways, we identified a variety of genes affecting vascular permeability, such as Cldn1, Dlg2, Bves, Prkag3, Cldn10, and Cldn8, which are related to tight junctions and control the permeability of blood vessels in tumors. The method presented here provides an MRI-supported approach to increase the breadth of data collected from genetic screens, reveals genetic evidence of the presence of NPs in tumors and lays a foundation for clinical patient stratification and personalized treatment. - Source: PubMed
Publication date: 2024/12/12
Liu DiLu NaZang FengchaoLu MingzeZhang JingyueZhao YingWan HaoWang MengjunLi Qian-QianWang FeiLuo ShouhuaMa MingShi FangfangWu HaoanTu JingZhang Yu - Evaluation of the effectiveness of vaccination of animals against rabies is not routinely implemented. In cases where it is carried out, the rapid fluorescent focus inhibition test (RFFIT) or the fluorescent antibody virus neutralization (FAVN) test are the recommended tests. However, both of these tests require handling of live rabies virus (RABV), and are cumbersome to perform. In view of this, the enzyme-linked immunosorbent assay (ELISA) has been proposed as a surrogate test; however, availability of appropriate antigen is a major impediment for the development of ELISAs to detect anti-rabies antibodies. The most widely used antigen is the RABV glycoprotein (G) purified from cell culture-propagated virus, which requires a biosafety level 3 containment. The alternative is to use recombinantly expressed G, which needs to be to be properly glycosylated and folded to serve as the best antigen. The most suitable system for its production is the baculovirus expression system (BVES). However, purification of RABV G is challenging. We therefore tested partially purified preparations in the form of extracts of insect cells infected with baculovirus expressing RABV G, against sera from vaccinated dogs in an indirect ELISA. The results showed good concordance against RFFIT, with sensitivity and specificity of 90.48% and 80.00%, respectively. The system may be used for quick screening to determine the presence and an approximate level of antibodies, and can be modified to enable monitoring of mass dog vaccination programs, as well as to facilitate certification of dogs intended for international travel and transportation. - Source: PubMed
Publication date: 2024/12/03
Santosh A KKumar DeepakKaur CharanpreetGupta PriyaJasmeen PagalaDilip LKavitha GBasagoudanavar SureshHosamani MadhusudanBalamurugan VSharada RRathnamma DSunil K MHegde Nagendra RIsloor Shrikrishna