Ask about this productRelated genes to: SLC27A4 Blocking Peptide
- Gene:
- SLC27A4 NIH gene
- Name:
- solute carrier family 27 member 4
- Previous symbol:
- -
- Synonyms:
- FATP4, ACSVL4
- Chromosome:
- 9q34.11
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-20
- Date modifiied:
- 2016-10-05
Related products to: SLC27A4 Blocking Peptide
Related articles to: SLC27A4 Blocking Peptide
- Antiviral treatment for chronic HBV infection in the "high-replicative low-inflammatory" phase has not been widely recommended. This study aimed to evaluate the safety and efficacy of antiviral therapy in this patient population and analyze peripheral immunological characteristics in relation to treatment response. In this randomized controlled trial, HBeAg-positive patients with normal ALT and elevated HBV DNA were randomly allocated 1:1 to receive TAF 25 mg/day or observation. The primary endpoint was the decline from baseline in HBsAg at Week 48. Secondary endpoints included HBV DNA response rates and the magnitude of HBV DNA reduction. The treatment group was further divided into virological response (VR) and low-level viremia (LLV) subgroups based on HBV DNA response at Week 48. PBMCs from VR (n = 3) and LLV (n = 3) patients underwent scRNA-seq for comparative immunological analysis. A total of 59 patients were allocated to the treatment (n = 30) and control (n = 29) groups. No serious adverse events occurred, except for one control patient who developed an ALT flare and required antiviral initiation. At Week 48, the treatment group demonstrated significantly greater reductions in HBsAg (0.19 vs. 0 log10 IU/mL, p = 0.005) and HBV DNA (6.32 vs. 0.19 log10 IU/mL, p < 0.001) compared to controls. In the treatment group, 20% achieved HBV DNA < 20 IU/mL and 3.3% achieved HBeAg seroconversion, while none occurred in the untreated patients. PBMCs scRNA-seq revealed dominant distributions of NK_FCER1G, NK_KLRF1, NK_XCL1, and NKT_FCGR3A subclusters in the VR group, with upregulated expression of genes such as SLC27A4 and PTMA. Taken together, our findings revealed that TAF demonstrates favorable safety and antiviral efficacy in patients with high-replicative, low-inflammatory HBV infection during the 48-week follow-up period, although complete virological suppression rates remain suboptimal. NK-mediated mechanisms may contribute to antiviral success. Trial Registration: The trial was registered on ClinicalTrials.gov (NCT04231565). - Source: PubMed
Luo QiuminXu RuixuanZhang YeqiongXu WenxiongLi XiangyongLai JingLi JianguoZheng XingrongDeng HongChen LubiaoZhu XiangXie ChanPeng Liang - This study aimed to determine whether fatty acids (FAs) may affect the function of the early porcine placenta. First, the expression of FA transporters (CD36, SLC27A) in conceptuses and placentae of days 10-11, 12-13, 15-16, 18-20, 25, and 30 pregnant gilts (n = 5-8 per group) was examined using Real-time PCR, Western blot, and immunohistochemistry. Then, primary trophoblast (pTr) cells from days 15-16 conceptuses were exposed to n-6 and n-3 polyunsaturated FAs (PUFAs) to study prostaglandin (PG) synthesis and the expression of genes related to FA action, angiogenesis, steroidogenesis, and lipid transport. Furthermore, pTr cell proliferation and adhesion in response to PUFAs were determined colorimetrically. Increased mRNA expression of CD36, SLC27A1, and SLC27A2 was detected in days 18-25 placentae compared with days 10-13 conceptuses. SLC27A4 and SLC27A6 expression was greater in days 10-11 spherical than in days 15-16 elongated conceptuses. SLC27A1, SLC27A4, and SLC27A6 were localized at the placenta-endometrium interface. PUFAs of n-6 series elevated PGE2 and PGI2 synthesis, whereas n-3 PUFAs stimulated PGE2 but inhibited PGI2 output. All PUFAs up-regulated the mRNA expression of CPT1A, a rate-limiting enzyme of FA β-oxidation. Moreover, docosahexaenoic acid (DHA) increased FABP5, SLC27A4, LDLR (lipoprotein receptor), and proangiogenic ANGPT1 and ANGPTL4 mRNA expression. DHA and arachidonic acid stimulated pTr cell proliferation, while linoleic and eicosapentaenoic acids increased cell adhesion. These results are the first demonstrating dynamic changes of FA transporter expression in peri-implantation conceptuses and developing placentae of the pig and indicate FA uptake by the early placenta. Furthermore, PUFAs may support placenta development by modulating gene expression, increasing PGE2 level, and promoting trophoblast cell viability and adhesion. - Source: PubMed
Publication date: 2026/05/02
Blitek AgnieszkaSzymanska Magdalena - This experiment investigated the effects of dietary Krasch. (AOK) supplementation on the n3-polyunsaturated fatty acid (n3-PUFA) profile of subcutaneous adipose tissue (SADT) in Arbas cashmere goats and explored the underlying transcriptional mechanisms. Forty healthy, weaned kids (120 ± 10 days of age; similar body weight) were randomly allocated to two groups ( = 20): a control group (CON, basal diet) and an AOK group (AOK, basal diet with 3% of the roughage replaced by AOK). The feeding trial spanned 104 days, consisting of a 14-day adaptation period and 90 days of data acquisition. Compared with the CON group, AOK significantly reduced the content of saturated fatty acids (SFAs) and n6-polyunsaturated fatty acids (n6-PUFAs)/n3-PUFAs (n6/n3). In contrast, the levels of n3-PUFAs in the SADT of cashmere goats increased markedly ( < 0.05). Compared with the CON group, AOK exhibited significantly higher activities of hormone-sensitive lipase (HSL) ( = 0.027), adenylyl cyclase 2 (ADCY2) ( = 0.010), adenylyl cyclase 5 (ADCY5) ( = 0.046), cluster of differentiation 36 (CD36) ( = 0.013), solute carrier family 27 member 4 (SLC27A4) ( = 0.021), and fatty acid binding protein 4 (FABP4) ( = 0.040), along with significantly lower activities of fatty acid synthase (FAS) ( = 0.002), lipoprotein lipase (LPL) ( = 0.048), and stearoyl-coa desaturase (SCD) ( = 0.026) in SADT. Compared with the CON group, the activities of superoxide dismutase (SOD) ( = 0.032), catalase (CAT) ( = 0.010), glutathione peroxidase (GSH-PX) ( = 0.029), and total antioxidant capacity (T-AOC) ( = 0.002) were significantly increased in the AOK group. Transcriptomic profiling revealed that AOK supplementation downregulated mRNA levels of , 5, , , , 1 (1), stearoyl- 2 (2), 1 (1), 1 (1), (), 1 (1), 1 (1), 27 2 (272), 4 (4), and 1 (1) ( < 0.05). It also markedly induced 4 (4) ( < 0.01) in SADT. Genes significantly enriched in the adenosine-monophosphate-activated protein kinase (AMPK) signaling pathway included , 1, 1, and 1 ( = 0.010). Genes significantly enriched in the phosphatidylinositol 3-kinase-akt (PI3K-Akt) signaling pathway included 1 and 4 ( = 0.015). 1, 2, and 1 were identified as the genes significantly enriched in the insulin resistance signaling pathway ( = 0.048). was the only gene significantly enriched in the cholesterol metabolism pathway ( = 0.049). Genes showing a tendency toward significant enrichment in the peroxisome-proliferator-activated receptor (PPAR) signaling pathway included 4, 1, 1, and ( = 0.051). These interconnected cascades improve insulin sensitivity, stimulate triglyceride (TG) hydrolysis, and modulate n3-PUFA levels. Supplementation with AOK enhances n3-PUFA content by accelerating TG breakdown while simultaneously restraining FA oxidation in SADT. Consequently, AOK supplementation can be effectively used to enhance the nutritional value of cashmere goat meat through improved n3-PUFA deposition in SADT. - Source: PubMed
Publication date: 2026/04/02
Jiang LianguangZhao YanliZhang QingyueZhang ShangxiongGuo XiaoyuGuo YongmeiYan Sumei - - Source: PubMed
Publication date: 2026/03/10
Miquel JulietteDeblock ConstanceVentejou SarahEspagnon CamilleSpodenkiewicz MartaBoumahni BrahimCharbit-Henrion FabienneHadj-Rabia Smail - Fat plays a key role in maintaining energy balance and supporting various physiological processes. HuAge-related disorders in fat utilization are increasingly prevalent, contributing to impaired energy balance, heightened metabolic disease risk, and increased cardiovascular dysfunction. The mechanism of age-induced disorders of fat utilization remains unclear. This study aims to explore the key factor affecting fat digestion and absorption during aging. Mice of different ages were used to analyze the changes of physiological and metabolic parameters with aging, including metabolic rate, energy expenditure, lean mass and apparent digestibility. Results showed that respiratory energy metabolism declined and fat apparent digestibility decreased significantly by more than 4% with aging. Fat is initially hydrolyzed in the intestine through combined actions of digestive enzymes and bile acids. Thus, the pancreatic lipase activity and total bile acids content were measured. The results revealed no significant changes in these factors. Furthermore, factors affecting fat absorption including intestinal structure and transporters expression were assessed. It was found that the crypt depth and villi height did not change significantly with age. Notably, intestinal proteomics analysis indicated that the expression of fatty acid transporter protein 4 (FATP4) was reduced by more than 50% in aged mice. In conclusion, this study demonstrated that age-related decline in FATP4 expression is linked to impaired intestinal fat absorption. This association may underlie the decreased fat apparent digestibility and impaired fat utilization during aging. These findings reveal the intrinsic mechanisms of age-induced dysregulation of fat utilization and providing a theoretical basis for enhancing fat utilization in older adults. - Source: PubMed
Publication date: 2026/02/05
Huang QianqianQiu LiliQin XiyuSong RuiZhou JunWang Xiaoyu