Ask about this productRelated genes to: SLC27A4 Blocking Peptide
- Gene:
- SLC27A4 NIH gene
- Name:
- solute carrier family 27 member 4
- Previous symbol:
- -
- Synonyms:
- FATP4, ACSVL4
- Chromosome:
- 9q34.11
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-20
- Date modifiied:
- 2016-10-05
Related products to: SLC27A4 Blocking Peptide
Related articles to: SLC27A4 Blocking Peptide
- Milk oligosaccharides (MOs) play a crucial role in the development of the epithelial barrier function in newborn mammals. - Source: PubMed
Publication date: 2026/08/18
Xie KunhongXu YedanYu BingHuang ZhiqingLuo YuhengZheng PingMao XiangbingYu JieLuo JunqiuHuiYan He Jun - - Source: PubMed
Akal CanHaskoloğlu Zehra Şuleİslamoğlu CandanSüleyman MerveAcar Mustafa OğuzKutlay Nüket YürürDoğu Esin Figenİkincioğulları Kamile Aydan - This experiment was conducted to investigate the effects of mulberry leaf powder (MLP) on alleviating fatty liver hemorrhagic syndrome (FLHS) in laying hens. A total of 180 healthy 33-week-old Hy-Line Gray laying hens were randomly assigned to 3 groups, with 6 replicates per group and 10 chickens per replicate, and fed a basal diet (CON), high-energy-low-protein (HELP) diet (FLHS), and HELP + 5% MLP diet (MLP), respectively. The experiment lasted 56 days. Results showed that the HELP diet successfully induced FLHS, characterized by an increased liver index, hepatic steatosis, and oxidative stress (P < 0.05). MLP significantly alleviated FLHS-induced hepatic steatosis, and enhanced antioxidant capacity (superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity, and glutathione) in serum and liver (P < 0.05). Transcriptomic analysis identified 102 differentially expressed genes, whose expression was increased by FLHS but reversed by MLP, including SREBF1, SLC27A4, PLIN2, ACOT13, APOA4, GLRX, and MSRB1, which mainly participate in lipid droplet dynamics and redox homeostasis. qRT-PCR confirmed that upregulated expression of lipogenic genes (such as FASN, ACACA, SCD, and ELOVL6) and the downregulated expression of oxidative stress-responsive genes (SOD1 and GPX1) in the FLHS group were normalized by MLP (P < 0.05), accompanied by increased expression of PPARα, CPT1A, and CD36 (P<0.05). 16S rRNA sequencing revealed that MLP reduced the abundance of Desulfovibrio, Rikenellaceae_RC9_gut_group, Intestinimonas, and Shuttleworthia, and enriched Faecalibacterium and Bifidobacterium in the cecum of FLHS laying hens (P < 0.05). Furthermore, MLP increased acetate, propionate, and butyrate levels, and decreased isobutyrate and isovalerate levels (P < 0.05). Correlation analysis showed that cecal acetate, propionate, butyrate, Faecalibacterium and Bifidobacterium were positively correlated with hepatic antioxidant enzyme activities (P < 0.05), and negatively correlated with hepatic lipogenic gene expression, hepatic lipid deposition and oxidative stress markers (P < 0.05). These findings indicated that MLP alleviated hepatic lipid metabolism disorders and oxidative stress in FLHS laying hens, which might be achieved by modulating gut microbiota structure and short-chain fatty acid production. - Source: PubMed
Publication date: 2026/07/16
Xuan LingLiu HongliZhang HengGao QingtaoShang YanLiu XuelanYan PeipeiShi TianhongFu Chunyan - In this study, an exploratory transcriptomic investigation was conducted to evaluate the feasibility of using feather transcriptomics to detect sex differences and gene responses to physiological changes in chickens. Feathers represent a promising non-invasive biological source of RNA, as the feather pulp of growing feathers contains living cells capable of active transcription. Growing feathers were collected from 150-day-old male and female chickens (Bionda Piemontese, a slow-growing breed) raised under a free-range system and fed two finisher diets differing in lipid content: low-lipid (LL, ether extract 3.6%) and high-lipid (HL, ether extract 9.3%) diets. RNA was extracted from feather pulp, and 12 pools were subjected to whole RNA-Seq analysis. The study was designed as 2 × 2 factorial experiments investigating the effects of diet and sex on gene expression. A total of 17,360 transcripts were detected and used for downstream analyses. Differential gene expression and functional enrichment analyses were performed. The main effects of diet and sex were estimated with an additive design using the DEseq2 package, while for the sex-specific diet analyses, subgroup comparisons were conducted on the RaNA-Seq platform. The analysis of the main effect of diet reveals that three genes associated with ether lipid metabolism (PLA2G10, PLA2G4F, and ENPP6) were upregulated in chickens fed the HL diet. In roosters, HL feeding significantly altered the expression of APOA1 and SLC27A4, suggesting an effect on lipid transport and metabolic regulation within the PPAR signaling pathway. In contrast, hens showed differential expression primarily in pathways related to apelin signaling, extracellular matrix remodeling, and cardiovascular function, rather than classical lipid metabolism pathways; additionally, gene set enrichment analysis indicated a limited enrichment of linoleic acid metabolism, suggesting secondary involvement of lipid metabolic processes. These findings are consistent with those in the literature reporting sex-related differences between males and females. The results further suggest that transcriptomic responses to dietary lipid supplementation can be investigated through the expression of selected candidate genes in feather pulp. Among the genes identified, PLA2G10, PLA2G4F, ENPP6, APOA1, and SLC27A4 emerged as potential molecular markers associated with dietary treatment, and the importance of sex-dependent transcriptional responses was highlighted. In conclusion, this study demonstrates the potential of feather pulp as a viable source of RNA for transcriptomic analyses in live chickens, providing a minimally invasive alternative to conventional tissue sampling. These preliminary results also support the hypothesis that feathers represent a practical and ethically favorable tissue for future nutrigenomic and genetic improvement studies, ultimately supporting more sustainable poultry production. - Source: PubMed
Publication date: 2026/07/05
Stoppani NadiaRaspa FedericaFiorilla EdoardoMaione SandraSchiavone AchilleMugnai CeciliaSoglia Dominga - We report a case of a six-month-old female infant weighing 4.56 kg who presented with altered mental status, severe metabolic acidosis, and multiorgan dysfunction following chronic use of an over-the-counter topical cream containing salicylic acid. The patient had a longstanding pruritic rash treated at home with multiple daily applications of the same topical salicylic acid-containing cream. She developed symptoms consistent with salicylate toxicity in the absence of known ingestion, confirmed by an elevated serum salicylate concentration. Intensive care was required to manage profound metabolic derangements, hepatic dysfunction, coagulopathy, thrombocytopenia, and hypoalbuminemia with third-spacing. Management included intravenous fluids, calcium gluconate, sodium bicarbonate therapy with urine alkalinization, potassium optimization, and supportive care. Dermatology evaluation raised concern for ichthyosis versus severe atopic dermatitis, and genetic testing was nondiagnostic except for a variant of uncertain significance in SLC27A4. The patient improved without dialysis and was discharged with dermatologic care instructions and close subspecialty follow-up. This case highlights the risk of systemic toxicity from topical salicylates in infants, particularly in the presence of impaired skin barrier function, and underscores the importance of cautious use of over-the-counter topical products in vulnerable pediatric populations. - Source: PubMed
Publication date: 2026/06/13
Pullukat KevinHusien Tarek