Ask about this productRelated genes to: Aste1 Blocking Peptide
- Gene:
- ASTE1 NIH gene
- Name:
- asteroid homolog 1
- Previous symbol:
- -
- Synonyms:
- HT001
- Chromosome:
- 3q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-01
- Date modifiied:
- 2017-05-22
Related products to: Aste1 Blocking Peptide
Related articles to: Aste1 Blocking Peptide
- Runs of homozygosity (ROH) are continuous segments of homozygous genotypes inherited from both parental lineages. These segments arise due to the transmission of identical haplotypes. The genome-wide patterns and hotspot regions of ROH provide valuable insights into genetic diversity, demographic history, and selection trends. In this study, we analyzed whole-genome resequencing data from 117 rabbits to identify ROH patterns and inbreeding level across eleven rabbit breeds, including seven Chinese indigenous breeds and four exotic breeds, and to uncover selective signatures based on ROH islands. - Source: PubMed
Publication date: 2025/04/29
Ping XinxinChen YuanWang HuiJin ZhuoyaDuan QiantingRen ZhanjunDong Xianggui - - Source: PubMed
Publication date: 2022/01/05
Huang BinhaoLi QinGeng QirongLao JiawenGuo JingHuang ShenglinXu Dazhi - Prostate cancer (PCa) is among the leading causes of cancer mortality. Dicycloplatin is a newer generation platinum-based drug that has less side effects than cisplatin and carboplatin. However, its effects in PCa is mixed due to lack of appropriate stratifying biomarkers. Aiming to search for such biomarkers, here, we analyze a group of PCa patients with different responses to dicycloplatin. - Source: PubMed
Publication date: 2021/07/27
Liu MingluZhou XiaoyuLiu JunLu ChelongZhang GuoqingZhang JingJiao Shunchang - - Source: PubMed
He Yizhou JosephChowdhury Dipanjan - The shieldin complex functions as the downstream effector of 53BP1-RIF1 to promote DNA double-strand break end-joining by restricting end resection. The SHLD2 subunit binds to single-stranded DNA ends and blocks end resection through OB-fold domains. Besides blocking end resection, it is unclear how the shieldin complex processes SHLD2-bound single-stranded DNA and promotes non-homologous end-joining. Here, we identify a downstream effector of the shieldin complex, ASTE1, as a structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA. ASTE1 localizes to DNA damage sites in a shieldin-dependent manner. Loss of ASTE1 impairs non-homologous end-joining, leads to hyper-resection and causes defective immunoglobulin class switch recombination. ASTE1 deficiency also causes resistance to poly(ADP-ribose) polymerase inhibitors in BRCA1-deficient cells owing to restoration of homologous recombination. These findings suggest that ASTE1-mediated 3' single-stranded DNA end cleavage contributes to the control of DSB repair choice by 53BP1, RIF1 and shieldin. - Source: PubMed
Publication date: 2021/08/05
Zhao FeiKim WootaeGao HuanyaoLiu ChaoZhang YongChen YupingDeng MinZhou QinHuang JinzhouHu QiChen Shih-HsunNowsheen SomairaKloeber Jake AQin BoYin PingTu XinyiGuo GuijieQin SisiZhang ChaoGao MingLuo KuntianLiu YilunLou ZhenkunYuan Jian