Ask about this productRelated genes to: MAPK14 Blocking Peptide
- Gene:
- MAPK14 NIH gene
- Name:
- mitogen-activated protein kinase 14
- Previous symbol:
- CSPB1, CSBP1, CSBP2
- Synonyms:
- PRKM14, p38, Mxi2, PRKM15
- Chromosome:
- 6p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1995-01-24
- Date modifiied:
- 2016-10-05
Related products to: MAPK14 Blocking Peptide
Related articles to: MAPK14 Blocking Peptide
- Naru-3 Wei Pill is a traditional Mongolian Medicine (TMM) that has anti-inflammatory, analgesic, and antibacterial effects. The present study aimed to demonstrate the anti-inflammatory and analgesic effect of Naru-3 Wei Pill, identify the core components and key targets and determine the pharmacological basis and mechanism of its blood-borne components. - Source: PubMed
Han ZhiqiangKang HusileZhang AidiQigeqin Baolechaolu Wulanqiqige Wang HuanXu YanhuaHaSi Anda Xue Lan - - Source: PubMed
Publication date: 2026/04/24
Zhao BingbingZhang Jie - To elucidate the molecular mechanisms by which aging exacerbates the severity of the Acute Respiratory Distress Syndrome (ARDS), with a specific focus on identifying and validating a novel signaling axis involving MAPK14, ADM, and MAPK8. - Source: PubMed
Publication date: 2026/04/17
Liu QingYin ChengFan LongLi DaxianWang Tianlong - Blume (RAP; Rhizophoraceae), a marine true mangrove, exhibits notable immunomodulatory potential, though its molecular mechanisms remain poorly understood. This study employed a pharmacoinformatics-based approach to predict the mechanism of its anti-inflammatory potential. Literature mining and GC-MS profiling identified 10 drug-like phytochemicals. Target prediction using SwissTargetPrediction, SuperPred, and PharmMapper, integrated with inflammation-associated gene databases, predicted 70 overlapping inflammation-related targets. Protein-protein interaction analysis of these targets yielded a highly enriched network (56 nodes, 190 edges; PPI enrichment < 1.0e). Functional enrichment analyses indicated strong associations with immune and inflammatory processes, including leukocyte migration, chemotaxis, and lipopolysaccharide response, alongside key inflammatory signalling pathways. Site-specific molecular docking of RAP phytochemicals against the topologically prominent targets EGFR, COX2, JAK2 and MAPK14 revealed favourable binding affinities. Notably, glycosin (), ( +)-dihydroquercetin (), and isolariciresinol (2) were predicted to bind stably to druggable anti-inflammatory targets. Molecular dynamics simulations further supported the stability of these complexes, particularly COX2 + , JAK2 + , and MAPK14 + . These findings provide testable mechanistic hypotheses for the anti-inflammatory effects of . - Source: PubMed
Publication date: 2026/04/17
Vishnu Walsan KalarikkalGuruvayoorappan Chandrasekharan - Coxsackievirus infection can cause various diseases such as myocarditis and encephalitis, posing a serious threat to human health. However, there are currently no specific therapeutic drugs or effective vaccines for Coxsackievirus infection, so exploring new anti-Coxsackievirus agents is of great significance. Geniposide, an iridoid glycoside component from traditional Chinese medicine Gardenia jasminoides, has shown multiple pharmacological activities, but its antiviral effect against Coxsackievirus and related mechanisms remain unclear. - Source: PubMed
Publication date: 2026/04/02
Xia JianboShi ZuliangShen Mengxin