Ask about this productRelated genes to: IARS Blocking Peptide
- Gene:
- IARS NIH gene
- Name:
- isoleucyl-tRNA synthetase
- Previous symbol:
- -
- Synonyms:
- ILRS, IARS1
- Chromosome:
- 9q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 1995-07-11
- Date modifiied:
- 2016-10-05
Related products to: IARS Blocking Peptide
Related articles to: IARS Blocking Peptide
- The perioperative management of patients using sodium-glucose cotransporter 2 inhibitors (SGLT2is) remains controversial. The US Food and Drug Administration currently recommends stopping SGLT2is for 3-4 days before surgery, irrespective of a diagnosis of diabetes mellitus. Other multisociety recommendations vary significantly in terms of SGLT2i management, perioperative monitoring, and mitigating strategies for euglycaemic diabetic ketoacidosis. This multidisciplinary consensus statement led by the Society for Perioperative Assessment and Quality Improvement (SPAQI) provides updated recommendations based on a modified Delphi process and supported by a systematic review of the literature. The recommendations include a tailored approach to management of SGLT2is perioperatively based on the presence of diabetes mellitus and other comorbidities, surgical and periprocedural dietary considerations, as well as monitoring and prevention strategies for euglycaemic diabetic ketoacidosis. - Source: PubMed
Publication date: 2026/04/30
Oprea Adriana DMohamed BasmaHepner David LAuron MoisesRichman Deborah CUmpierrez Guillermo EEdmonston DanielIonescu CostinKumar MandeepSweitzer BobbieJean - Anti-recombinant human acid α-glucosidase (rhGAA) antibodies can develop in adult Pompe patients receiving enzyme replacement therapy (ERT), but their long-term impact on clinical treatment outcomes is currently unclear. - Source: PubMed
Publication date: 2026/04/13
Theunissen Maudy T MDitters Imke A Mvan Kooten Harmke Avan Doorn Pieter Avan den Hout Johanna M PHoogeveen-Westerveld MarianneJacobs Edwin Hvan der Ploeg Ans Tvan der Beek Nadine A M E - - Source: PubMed
Publication date: 2026/04/13
Pestel Gunther - Geese are key domesticated waterfowl in Asia, where annual egg number and laying duration influence economic value. To investigate the genomic basis of laying seasonality, we generated whole-genome resequencing data for 314 geese from six Chinese breeds and focused on three with contrasting reproductive schedules: low-latitude Ding'an geese, which have a prolonged laying period with moderate annual egg yield, and high-latitude Huoyan and Zi geese, which show short, highly seasonal laying but high egg production. By integrating Fst, GWAS and haplotype-based statistics, we identified 16 candidate genes, including reproduction-related loci (AGTR2, IARS, PCGF6) and retinal genes (FRMD4B, PROS1, SH2D3C, ZEB2). Genomic regions surrounding PCGF6 and PROS1 showed clear signatures of selection, with reduced nucleotide diversity and strongly differentiated haplotypes between latitude-defined groups. Multiple downstream and 3' untranslated-region SNPs at these loci exhibited large allele-frequency shifts and are predicted to alter transcriptional regulation, suggesting a link between retinal photoreception, photoperiodic or circadian signaling and the timing and duration of egg laying. These findings highlight the role of retinal pathways in goose reproductive seasonality and provide targets for genomic selection to potentially extend the laying period. - Source: PubMed
Publication date: 2026/03/24
Chen HaoMiao JunjieHu YimingZhou JingTan HongliLi JingMao HuirongOuyang JingHuang MinGu LihongYan Xueming - Infantile-onset Pompe disease (IOPD) is a life-threatening lysosomal storage disorder, caused by deficiency of the acid alpha-glucosidase (GAA) enzyme. While enzyme replacement therapy (ERT) with recombinant human GAA (rhGAA) is the standard treatment, its efficacy in cross-reactive immunological material (CRIM)-negative patients is often complicated by severe infusion-associated reactions (IARs), posing significant challenges to management. - Source: PubMed
Publication date: 2026/03/16
Zhou JueruWang QianZhang HanWang YuqiWang ZiweiYang FanYang Shiwei