Ask about this productRelated genes to: Rab27b Blocking Peptide
- Gene:
- RAB27B NIH gene
- Name:
- RAB27B, member RAS oncogene family
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 18q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-11-15
- Date modifiied:
- 2015-08-25
Related products to: Rab27b Blocking Peptide
Related articles to: Rab27b Blocking Peptide
- - Source: PubMed
Publication date: 2026/04/22
Badell-Grau Rafael A - Temporomandibular disorders (TMD) show substantial clinical and genetic overlap with anxiety, yet it remains unclear whether TMD risk reflects shared anxiety-related liability or distinct anxiety-independent genetic mechanisms. Disentangling these components is essential for understanding TMD heterogeneity beyond symptom-based classifications. - Source: PubMed
Publication date: 2026/03/09
Cao YuYang XinSvensson PeterChung Wen Raymond WongHan Sng Timothy JieIslam IntekhabHan WeiFeng XingmeiHou BozhiLi YuehuaZheng Lei - Although growing evidence suggests that obesity/central adiposity predisposes to the development and exacerbation of heart failure with preserved ejection fraction (HFpEF), it remains to be clarified whether there is a causal relationship between adiposity and HFpEF pathogenesis. - Source: PubMed
Pan QiChen ChengZhang CeJiang YaoZhou ZiqinZhang HanGillette Thomas GHill Joseph ASchiattarella Gabriele GWu GuixinYang YuejinChen Guihao - Extrusion of damaged mitochondria is emerging as a trigger of innate immune activation. Parkinson's disease (PD), characterized by profound mitochondrial dysfunction, may involve similar mechanisms. Here, we report that dopaminergic neurons release damaged mitochondria into the extracellular space in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. These neuron-derived mitochondria were subsequently engulfed by glial cells, eliciting robust inflammatory responses. Autophagy inhibition did not affect mitochondrial release, indicating a non-canonical extrusion pathway. Upon mitochondrial damage, Rab27a and Rab27b translocated to the outer mitochondrial membrane, mediating mitochondrial export from dopaminergic neurons. Conditional Rab27 knockdown in dopaminergic neurons reduced extracellular mitochondrial accumulation, microglial activation, antiviral signaling, and dopaminergic neurodegeneration. Together, these findings identify Rab27-dependent mitochondrial extrusion as a critical mechanism coupling dopaminergic neuronal injury to neuroinflammation and neurodegeneration in PD. - Source: PubMed
Publication date: 2026/01/29
Xu YingqiLi JunyuMa ShanshanYang TingShen ZiyueLi MingtaoHuang Qiaoying - Colorectal cancer (CRC) is the third most common cancer worldwide. Advanced CRC has a grim prognosis, so there is a high demand for an early non-invasive diagnostic biomarker. - Source: PubMed
Publication date: 2026/01/28
Yu YueJiang XianchenPei BingZhou JundeLong ZhipingCao YukunYe JingyuGao YuXie KunYuan HeliJia YanjieZhang MinLiu XiaoZhao YashuangNing HuaWang Fan