MLSTD1 Blocking Peptide
- Known as:
- MLSTD1 Blocking Peptide
- Catalog number:
- 33r-10019
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- MLSTD1 Blocking Peptide
Related genes to: MLSTD1 Blocking Peptide
- Gene:
- FAR2 NIH gene
- Name:
- fatty acyl-CoA reductase 2
- Previous symbol:
- MLSTD1
- Synonyms:
- FLJ10462, SDR10E2
- Chromosome:
- 12p11.22
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-01
- Date modifiied:
- 2016-10-05
Related products to: MLSTD1 Blocking Peptide
Related articles to: MLSTD1 Blocking Peptide
- Sus scrofa has been domesticated under diverse environments and management systems, leading to broad variation in genetic architecture and physiological regulation. This diversity has been preserved in indigenous breeds maintained under traditional husbandry and further expanded through modern crossbreeding programs designed to combine the distinctive attributes of native and commercial lineages. To investigate how such lineage diversity is reflected at the structural genomic level, whole-genome sequencing data from 110 pigs representing 13 populations were analysed to characterize genome-wide copy number variation (CNV) patterns and identify regions showing differential CNV patterns among lineages. Comparative analysis revealed distinct CNV landscapes between indigenous and commercial groups, encompassing 282 significantly differentiated CNV regions (CNVRs). Selection signatures defined by V and Wilcoxon tests highlighted genes involved in lipid metabolism (FAR2, MGLL, FASN), suggesting that CNV differences may underlie the characteristic fat-deposition traits of native breeds. Within the same analytical framework, crossbred populations exhibited inheritance patterns consistent with parental lineage influence: native-like CNVRs harboured lipid-associated genes (ADIPOR1, MLXIPL, GPIHBP1), whereas commercial-like CNVRs contained loci related to muscle development and growth (CAPN1, PDGFA, EEF1A2, SH2B1). These results collectively provide genomic insight into how CNVs reflect the effects of historical adaptation and selective breeding in domestic pigs. The differentiated CNVRs identified here encompass genes involved in fat deposition and muscle biology, suggesting potential links to trait variation across lineages. This work offers a genomic foundation for future studies integrating CNV and functional traits, and highlights the value of structural variation in informing crossbreeding and breed-improvement strategies. - Source: PubMed
Kim BongsangSeo JeongwooKim HeebalKim Young-SinLee JonganCho Seoae - This study aimed to identify inflammatory subtypes of asthma using peripheral blood transcriptomics and to derive candidate biomarkers supported by multi-level validation. - Source: PubMed
Publication date: 2026/03/13
Zhou XiaofeiChen YuhuiHui Yu - Wax esters (WEs) are lipids characteristic of sebaceous glands and are classified into wax monoesters (WmEs) and wax diesters (WdiEs). Here, we analyzed WEs in mouse sebum via liquid chromatography-tandem mass spectrometry to characterize their composition and structural diversity. We found that mouse sebum contained type 2α and type 2ω WdiEs and revealed the detailed species composition of these WdiEs together with WmEs. In knockout mice of the acyl-CoA reductase , the quantities of WEs with very-long-chain fatty alcohols were reduced relative to wild-type mice. In knockout mice of the acyl-CoA wax alcohol acyltransferase , the quantities of many WmEs and type 2ω WdiEs containing long-chain fatty acids were decreased. Sebum WEs were substantially more diverse than meibum WEs. These findings reveal that mouse sebum contains WEs comprising a variety of fatty acids and fatty alcohols and provide clues to the molecular mechanism of their production. - Source: PubMed
Publication date: 2026/01/29
Kuribayashi KarinJojima KeisukeYamamoto MoeTakeda MireiKihara Akio - To investigate the associations between fibrinogen to albumin ratio (FAR) and remote diffusion-weighted imaging lesions (RDWILs) as well as 1-month short-term outcomes in patients with acute intracerebral hemorrhage (ICH). - Source: PubMed
Publication date: 2025/09/23
Zhu YutingZhang TengWang YinggeXu Xiaotian - Mammalian cell membranes contain ether lipids, which include an alkyl chain derived from a fatty alcohol that is produced by fatty acyl-CoA reductases (FARs). There are two mammalian FAR genes, and , and mutations in cause the peroxisomal fatty acyl-CoA reductase 1 disorder (PFCRD), which is accompanied by various symptoms, including neurological disorders. To date, the contributions of and to brain ether lipid production and the molecular mechanism of PFCRD have remained unknown. To investigate these, we analyzed knockout (KO) mice of and . In the brain, the expression levels of were higher than those of , and was widely expressed. Lipidomic analyses showed that the quantity of ether lipids ethanolamine-plasmalogens was reduced in KO mice, with a complementary increase in diacyl-type phosphatidylethanolamines, but not in KO mice. Electron microscope analysis of the corpus callosum revealed reductions in the percentage of myelinated axons and myelin thickness in KO mice relative to WT mice. In conclusion, FAR1 is the major FAR isozyme involved in ether lipid synthesis in the brain, and its deficiency causes hypomyelination. We speculate that this hypomyelination is one of the causes of the neurological symptoms of PFCRD. - Source: PubMed
Publication date: 2025/09/11
Takahashi TengaOtsuka KentoSassa TakayukiKihara Akio