MGC42174 Blocking Peptide
- Known as:
- MGC42174 Blocking Peptide
- Catalog number:
- 33r-9966
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- MGC42174 Blocking Peptide
Related genes to: MGC42174 Blocking Peptide
- Gene:
- DIS3L2 NIH gene
- Name:
- DIS3 like 3'-5' exoribonuclease 2
- Previous symbol:
- FAM6A
- Synonyms:
- FLJ36974, MGC42174
- Chromosome:
- 2q37.1
- Locus Type:
- gene with protein product
- Date approved:
- 2007-01-17
- Date modifiied:
- 2019-04-23
Related products to: MGC42174 Blocking Peptide
Related articles to: MGC42174 Blocking Peptide
- Zinc-finger antiviral protein (ZAP)-mediated RNA decay (ZMD) restricts the replication of viruses containing CpG dinucleotide clusters. However, why ZAP isoforms differ in antiviral activity and how they recruit cofactors to mediate RNA decay is unclear. Therefore, we determined the ordered events of the ZMD pathway. The long ZAP isoform preferentially binds viral RNA and has distinct binding motifs compared to the short isoform. The endoribonuclease KHNYN then cleaves viral RNA at positions of ZAP binding. The 5' cleavage fragment undergoes TUT4/TUT7-mediated 3' uridylation and degradation by DIS3L2. The 3' cleavage fragment is degraded by XRN1. ZAP and TRIM25 interact with KHNYN, TUT7, DIS3L2, and XRN1 in an RNase-resistant manner. Viral infection promotes the interaction between TRIM25 with these enzymes, leading to viral RNA decay while also decreasing the abundance of cellular transcripts. Overall, the long isoform of ZAP recruits key enzymes to assemble an RNA decay complex on viral RNA. - Source: PubMed
Publication date: 2026/04/28
Bouton Clément RGimpelj Domjanič GregaLista María JoséGalão Rui PedroCourty ThomasKwiatkowski PiotrWilson Harry DHill Peter W SMischo Hannah EChakrabarti Anob MPoljak MarioUle JernejNeil Stuart J DSwanson Chad M - Perlman syndrome is a rare autosomal recessive overgrowth disorder characterized by macrosomia, nephromegaly, renal dysplasia, and characteristic facial features. It has both similarities and differences to other more common overgrowth syndromes. Pathogenic homozygosity is extremely rare in nonconsanguineous relationships. Survival is predicted by differences among various germline mutations in the DIS3L2 gene on chromosome 2q37.1, with prolonged survival documented in heterozygous mutations allowing partial exoribonuclease function. Although homozygous deletions of exon 9 are rare and have been associated with poor survival, we describe a case report of the only known patient with Perlman syndrome to live past 2 years old with this deletion. Diligent management and surveillance may be associated with prolonged survival in Perlman syndrome. - Source: PubMed
Publication date: 2026/04/25
Levy EstherElliott LeightonMiller Michal AKramer Mackenzie - MicroRNAs (miRNAs) are pivotal post-transcriptional regulators of gene networks in development and disease, with their functional output critically dependent on dynamic turnover. Dysregulation of miRNA turnover disrupts signaling fidelity and contributes to pathologies such as cancer and infection. This review synthesizes recent advances in understanding miRNA turnover, focusing on key degradation pathways-including ZSWIM8-mediated target-directed miRNA decay (TDMD), TUT4/7-DIS3L2-driven uridylation, and nuclease cleavage-and how they integrate with stability factors such as AGO association, terminal modifications, and sequence features to orchestrate global miRNA abundance and health status. From these insights, critical unresolved questions are delineated, such as identifying nucleases responsible for degrading TDMD-liberated miRNAs and elucidating compartment-specific degradation mechanisms in physiological contexts like the gut lumen and circulation. Addressing these questions will facilitate innovative strategies for targeting miRNA stability within precision medicine. This article is categorized under: RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA Turnover and Surveillance > Regulation of RNA Stability Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action. - Source: PubMed
Lin ZiqiWen WeijieIrfan MuhammadXu TielongZhou Xianfeng - Although most studies of the RNAs within extracellular vesicles (EVs) have focused on messenger RNA (mRNA) and microRNAs (miRNAs), recent analyses have revealed that transfer RNAs (tRNAs) and other noncoding RNAs (ncRNAs) are far more abundant. However, the extent to which EV ncRNAs resemble overall cellular RNAs and the benefits to host cells of packaging them into EVs remain unknown. Here, we purified EVs from the culture media of mouse and human cells and characterized their RNA components using high-throughput sequencing and Northern blotting. We report that EVs are enriched for numerous aberrant ncRNAs, including ncRNA fragments, ncRNAs that have failed to mature, and short structured introns. Many RNAs contain oligouridine tails, a modification that can promote degradation by DIS3L2, an exoribonuclease that degrades defective structured ncRNAs. Both the numbers of EVs released and the fractions of tailed RNAs in EVs increase on DIS3L2 depletion, indicating that EV packaging of aberrant ncRNAs occurs in competition with DIS3L2 decay. Multiple type I interferon-stimulated genes (ISGs) are upregulated on DIS3L2 depletion, and cells treated with a neutral sphingomyelinase inhibitor that reduces exosome biogenesis show moderate ISG upregulation, an effect that is enhanced in DIS3L2-depleted cells and accompanied by accumulation of aberrant ncRNAs in cellular RNA. Thus, DIS3L2 degradation and packaging of aberrant RNAs into vesicles may prevent these RNAs from activating innate immune sensors and triggering an interferon response. - Source: PubMed
Publication date: 2025/12/16
Williams Sandra GSim SoyeongGuiblet Wilfried MGeorge JubinJones Jennifer CWolin Sandra L - Carney-Stratakis syndrome (CSS) is a rare hereditary disorder involving gastrointestinal stromal tumors (GISTs) and paraganglioma/pheochromocytoma, typically linked to mutations in the , , and genes. The unique mechanism of tumorigenesis, including pseudohypoxia and hypermethylation caused by succinate dehydrogenase deficiency, renders target therapy with tyrosine kinase inhibitors ineffective; therefore, complete surgical resection is the optimal treatment in the absence of tumor metastases. Herein, we report the case of a 74-year-old woman with gastric GIST and urinary bladder paraganglioma. Molecular testing on the gastric GIST revealed a exon 11 mutation, and germline testing showed a variant of uncertain significance in the gene. The patient has been on imatinib since July 2023 with controlled disease. To the best of our knowledge, this is the first reported case of CSS with a variant. Further reports and studies are needed to establish a definitive association between this gene and CSS. - Source: PubMed
Publication date: 2025/09/02
Saleh YacobAl Kiswani SomayaMuhtaseb AhmadAl-Adhami DhuhaKhader MajdJaber OmarNofal AbdullahAl-Ibraheem Akram