Ask about this productRelated genes to: APEH Blocking Peptide
- Gene:
- APEH NIH gene
- Name:
- acylaminoacyl-peptide hydrolase
- Previous symbol:
- D3F15S2, DNF15S2, D3S48E
- Synonyms:
- -
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-24
- Date modifiied:
- 2016-10-05
Related products to: APEH Blocking Peptide
Related articles to: APEH Blocking Peptide
- This study evaluated the cardioprotective potential of Vitex simplicifolia methanol extract (VSME) and explored its underlying mechanisms of action. Twenty-five male rats were assigned to five groups (n = 5). Group 1 served as the normal control, while groups 2-5 were exposed to 5 mg/kg body weight of cadmium chloride (CdCl) daily. Group 2 received no treatment, whereas groups 3 and 4 were treated with 200 and 400 mg/kg VSME, respectively, and group 5 received 10 mg/kg propranolol (standard drug), all for 21 days via oral administration. Biochemical and histopathological analyses of the heart were conducted post-treatment. Cadmium exposure significantly elevated cardiac malondialdehyde, triglycerides, cholesterol, low-density lipoprotein, creatine kinase, lactate dehydrogenase, and C-reactive protein, while reducing high-density lipoprotein, superoxide dismutase (SOD), catalase, and glutathione peroxidase. VSME treatment reversed these changes, restoring antioxidant status, lipid profile, cardiac biomarkers, and myocardial architecture. Molecular docking revealed strong binding affinities of VSME phytochemicals (kaempferol, isorhamnetin, luteolin) with Kelch-like ECH-associated protein 1 (Keap1), primarily through hydrogen bonds. These compounds exhibited superior drug-likeness, pharmacokinetics, and safety profiles compared to the standard Keap1 inhibitor, CPUY192018. These findings suggest that VSME may exert cardioprotective effects partly through antioxidant activity and potential interference with the Keap1-Nrf2 interaction, as supported by molecular docking. - Source: PubMed
Chukwuma Ifeoma FEze Okechukwu IgnatiusOkeke Ogechukwu ColetApeh Victor OEzeorba Timothy Prince ChidikeOkafor Chima - Water is essential for life; however, it serves as the route of transmission for many infectious pathogens. The increasing prevalence of multidrug-resistant (MDR) bacteria in water samples poses a significant public health risk. - Source: PubMed
Publication date: 2026/02/03
Apeh John OMeshach Emmanuel AFagbemi Oluwabusayo TAdetunji Modupeade CAransiola Michael NShaibu Joseph OEnwuru Christian A - BackgroundCardiac surgery requiring cardiopulmonary bypass began at Federal Medical Centre (FMC), Abuja, in February 2022 through visiting mission teams. Continuous collaboration between subsequent missions and local staff has led to progressive skills acquisition and increasing independence in both adult and pediatric cardiac surgery. This report outlines our path to independence and the challenges encountered.MethodsFrom February 2022 to December 2024, we reviewed 45 patients who underwent cardiac surgery with cardiopulmonary bypass. Data included the operating team (visiting vs local), case type, and outcomes.ResultsOf 45 surgeries, visiting teams performed 27 (11 adult, 16 pediatric) and local surgeons performed 18 (5 adult, 13 pediatric). Six surgical missions were conducted. The proportion of cases done independently by local surgeons increased from 14.3% in 2022 (n = 7) to 26% in 2023 (n = 23), and 73% in 2024 (n = 15). Competence was achieved first by cardiologists, followed by scrub nurses, intensive care unit nurses, anesthetists, and surgeons. The local perfusionist has yet to attain independence, representing a major program limitation. Of 45 operations, nine mortalities (20%) occurred-five in visiting-team cases and four in local-team cases. All but one were pediatric, and all occurred postoperatively.ConclusionStructured collaboration with visiting missions, deliberate skills transfer, and perseverance have enabled rapid development of cardiac surgical competence at the Federal Medical Centre, Abuja. While adult and selected pediatric cases are now managed independently, further progress requires dedicated perfusionist training and improved pediatric postoperative care. - Source: PubMed
Publication date: 2026/01/29
Alioke Ikechukwuka IIdoko Francis LIgwe Stanley NApeh Charles IMaduka Ogechi C DPapka Nubwa YAbiodun Olugbenga OSalau Ibrahim LAnumenechi NdubuisiAkanni BolajiAfolayan Abdul-Gafar - Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by α-synuclein aggregation, mitochondrial dysfunction, and impaired proteostasis. The peripheral biomarkers that reflect these cellular perturbations remain incompletely defined. This study aimed to evaluate the enzymatic activity and gene expression of two key protein degradation enzymes, Acyl PEptide Hydrolase (APEH) and Proteasome Subunit Beta Type-5 (PSMB5), in the peripheral blood of PD patients and to relate these findings to the severity of the disease. Thirteen PD patients and 13 age-matched healthy controls (HLT) were recruited. APEH and PSMB5 chymotrypsin-like (CT-like) activity were measured in whole blood, erythrocytes and immune cell fractions. Gene expression analysis was performed for APEH and PSMB5 and their related genes, plus other genes typical of parkinsonism or indicative of metabolic alterations: N(alpha)-acetyltransferase (NAA10) Aminoacylase 1 (ACY1), Ubiquitin-activating enzyme 1 (UBA1), Ubiquitin conjugating enzyme E2 I (UBE2I), Parkin RBR E3 ubiquitin protein ligase (PRKN), Alpha-synuclein (SNCA), Parkinsonism associated deglycase DJ-1 (PARK7), and mitochondrial Mn-SOD (SOD2). APEH activity did not differ significantly between PD and HLT in whole blood cells or cellular fractions. Conversely, PSMB5 CT-like activity was reduced in lymphocytes from PD patients, whereas erythrocytes and whole blood exhibited elevated activity. No changes in APEH and PSMB5 expression were observed, while PARK7 significantly decreased in patients with PD. Correlation analysis showed that proteasomal changes correlated with disease severity, and cognitive impairment. Our findings revealed compartment-specific proteasomal dysregulation in the peripheral blood of PD patients, suggesting systemic proteostasis imbalance. These alterations appeared more pronounced in patients with more severe clinical progression. This study supports the potential of peripheral proteasomal activity profiles as biomarkers linked to PD progression, warranting further investigation in larger cohorts. - Source: PubMed
Publication date: 2025/12/24
Di Costanzo AlfonsoFusco CarmelaCamerlingo RosaSerafini SaraMinò AntonioTiberio CristianaPalmieri GiannaMatrone CarmelaCocca EnnioAngiolillo Antonella - The management of patients with acute paraesophageal hernia (APEH) remains to be standardized. This study evaluates the safety and outcomes of a novel staged approach for patients with APEH, which is based on gastric decompression followed by non-operative management and either emergency or semi-elective surgical treatment when deemed necessary. - Source: PubMed
Publication date: 2025/12/08
Biel EnriqueJaume-Bottcher SofiaMontcusí BlancaSánchez-Parrilla JuanManterola CarlosGrande LuisPera Manuel