Ask about this productRelated genes to: NIP7 Blocking Peptide
- Gene:
- NIP7 NIH gene
- Name:
- nucleolar pre-rRNA processing protein NIP7
- Previous symbol:
- -
- Synonyms:
- CGI-37, FLJ10296, HSPC031, KD93
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-12-01
- Date modifiied:
- 2019-01-21
Related products to: NIP7 Blocking Peptide
Related articles to: NIP7 Blocking Peptide
- This study systematically analyzed the expression profiles of exosome-associated genes in Major Depressive Disorder (MDD), constructed diagnostic models, and explored their association with immune regulation, pharmacological targeting, and molecular regulatory networks. - Source: PubMed
Publication date: 2026/04/22
Li YingHuang JinsongMiao PeidongLi FangFan LijunZhang Yunan - To investigate the role of nucleolar pre-rRNA processing protein NIP7 (NIP7) in maintaining the malignant phenotype of anaplastic thyroid cancer (ATC) and its molecular mechanisms. - Source: PubMed
Gong YingyingFang ZiwenWang YixuanGe MinghuaPan Zongfu - Boron (B) is an essential micronutrient for the development of crops, and its reproductive stage is particularly sensitive to B deficiency. L., as an important oil-crop species, is extremely vulnerable to B deficiency. The typical B-deficient symptom of "flowering without seed setting" usually results in severe yield loss. However, few studies have focused on the response of the reproductive organs to B deficiency. In this study, the B-efficient variety "Zhongshuang 11" (ZS11) and the B-inefficient variety "Westar 10" (W10) of were selected to be cultivated at the developmental stage (BBCH15) in a pot experiment, both with and without B supply. Clear phenotype differences in B deficiency between the two varieties' flowers appeared only at the reproductive stage, and only W10 showed symptoms of delayed flower opening, stigma exsertion, and resulted in abortion. Transcriptome analysis for the early buds of both varieties between B supply (+B) and free (-B) treatments revealed that W10 had more differentially expressed genes (DEGs) corresponding to its greater susceptibility to -B. As two potential mechanisms to improve B-efficient utilization, we focused on analyzing the expression profiles of B transporter-related genes and phytohormone metabolism-related genes. , and were identified as the key genes which could enhance the capacity of B translocation to buds of ZS11. Additionally, combined with a phytohormone concentration measurement, we showed that a significant increase in IAA and a drastic decrease in JA could predominantly lead to the abnormal development of W10's buds. () and (), which are IAA and JA biosynthesis genes, respectively, could be the key genes responsible for the changes in IAA and JA concentrations in W10's buds under -B. These candidate genes may regulate the genotype differences in the response of the rapeseed reproductive stage to -B between different B-efficient varieties. It also has potential to breed rapeseed varieties with B-efficient utilization in the reproductive stage, which would improve the seed yield under -B condition. - Source: PubMed
Publication date: 2025/03/10
Jiang ZhexuanLiu LanWang SheliangYe XiangshengLiu ZhaojunXu Fangsen - Boron is an essential micronutrient required for plant cell wall integrity, as it is necessary for crosslinking the pectic polysaccharide rhamnogalacturonan II. Reproductive organs require a greater amount of boron for development and growth compared with vegetative organs. However, the mechanism by which plants distribute boron to specific organs is not fully understood. Under boron-limited conditions, the borate exporter BOR1 plays a central role in transporting boron from the roots to the shoots in Arabidopsis (Arabidopsis thaliana). Here, we found that BOR1 is expressed in the tapetal cells of young anthers in unopened buds, showing polar localization toward the locule where microspores develop. Tapetum-localized BOR1 undergoes endocytosis and is subsequently degraded during anther development. BOR1 degradation occurs independently of the lysine residue at Position 590 of BOR1, which is responsible for high boron-induced ubiquitination and degradation. Loss-of-function bor1 mutants exhibit disrupted pollen structure, causing reduced fertility under boron-sufficient conditions in the wild type. These phenotypes were rescued by supplementing with high boron concentrations. Furthermore, inflorescence stem grafting experiments suggested that BOR1-dependent boron transport in the flower is necessary for pollen development and subsequent fertilization under boron-sufficient conditions. Our findings suggest the borate exporter BOR1, together with the previously described boric acid channel NIP7;1, facilitates boron transport in tapetal cells toward the locule, thereby supporting pollen development in young anthers under boron-limited conditions. - Source: PubMed
Muro KeitaYamasaki ArisaMatsumoto MakiTanaka Yu-KiOgra YasumitsuFujiwara ToruYoshinari AkiraTakano Junpei - Ribosome biogenesis (RiboSis) is a complex process for generating ribosomes, the cellular machinery responsible for protein synthesis. Dysfunctional RiboSis can disrupt cardiac structure and function, contributing to cardiovascular diseases. This study employed a Mendelian randomization (MR) approach, integrating multi-omics data, to investigate the relationship between RiboSis-related genes and standard cardiac structure and function. - Source: PubMed
Publication date: 2025/03/05
Wei ShuxuShen RonghuaiLu XiaojiaLi XinyiHe LingbinZhang YoutiYang JiahangShu ZhouwuHuang Xianxi