Ask about this productRelated genes to: SLC22A23 Blocking Peptide
- Gene:
- SLC22A23 NIH gene
- Name:
- solute carrier family 22 member 23
- Previous symbol:
- C6orf85
- Synonyms:
- FLJ22174
- Chromosome:
- 6p25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-20
- Date modifiied:
- 2015-12-08
Related products to: SLC22A23 Blocking Peptide
Related articles to: SLC22A23 Blocking Peptide
- Alzheimer's disease (AD) has genetic and environmental risk factors, including cigarette smoking. Gene-environment interactions may explain AD missing heritability. - Source: PubMed
Dacey RyanHou LeiGurnani AshitaHan XudongPaller-Moore Mackenzie RChung JaeyoonDurape ShrutiRosenthaler MaxUretsky MadelineAbdolmohammadi BobakLee Annie JBrickman Adam MHohman Timothy JCuccaro Michael LBennett David ACrane Paul KKamboh M IlyasKukull Walter AJun GyungahStein Thor DMcKee Ann CHaines Jonathan LPericak-Vance Margaret AWang Li-SanSchellenberg Gerard DMayeux RichardLunetta Kathryn LFarrer Lindsay AMez Jesse - As the laying cycle is prolonged, the egg albumen quality exhibits a declining trend. A Haugh unit (HU) is a standard measure of the albumen quality, which reflects viscosity and freshness. During the late laying period, the HU not only decreased significantly, but also exhibited greater variability among individuals. The magnum, as the primary site of albumen synthesis, plays a central role in this process; however, the mechanisms by which it regulates the albumen quality remain unclear. To address this, we obtained genomic and transcriptomic data from 254 individuals, along with single-cell RNA sequencing (scRNA-seq) data of the magnum tissue. Genome-wide association studies (GWAS) across five laying stages (66, 72, 80, 90, and 100 weeks of age) identified 77 HU-associated single-nucleotide polymorphisms (SNPs). Expression quantitative trait locus (eQTL) mapping linked these variants to the expression of 12 genes in magnum tissue. In addition, transcriptomic analysis using linear regression and random forest models identified 259 genes that significantly correlated with the HU. Single-cell RNA sequencing further revealed two key cell types, plasma cells and a subset of epithelial cells, marked by and , which are functionally relevant to the HU. Through integrated Transcriptome-Wide Association Study (TWAS) and Summary-data-based Mendelian Randomization (SMR) analyses, we identified four robust regulators of the albumen quality: , , , and . These genes are functionally involved in mitochondrial function, antioxidant defense, and membrane transport. Overall, our findings uncovered the genetic and cellular mechanisms underlying age-related decline in the albumen quality and identified potential targets for improving the egg quality in aging flocks. - Source: PubMed
Publication date: 2025/08/15
Gao MingyueZhang JunnanYang NingSun Congjiao - Egg quality directly determines embryo development in meat-type poultry. However, it is difficult to directly select the egg quality of Muscovy duck. The genes and SNPs associated with egg quality screened by GWAS can be used for molecular breeding and accelerate the progress of selection in Muscovy duck. - Source: PubMed
Publication date: 2025/04/29
Yang WanliYu ShiqiSong DanyuLin WeihuangXu HanqiLang XuqiaoZhang ChengGuo LipingChen Xingyong - Epidemiological studies suggest that poor nutrition during pregnancy predisposes offspring to the development of lifestyle-related noncommunicable diseases and psychiatric disorders later in life. However, the molecular mechanisms underlying this predisposition are not well understood. In our previous study, using rats as model animals, we showed that behavioral impairments are induced by prenatal undernutrition. In this study, we identified solute carrier 22 family member 23 (Slc22a23) as a gene that is irreversibly upregulated in the rat brain by undernutrition during fetal development. Because the substrate of the SLC22A23 transporter has not yet been identified and the biological role of the Slc22a23 gene in vivo is not fully understood, we generated pan-Slc22a23 knockout rats and examined their phenotype in detail. The Slc22a23 knockout rats showed a lean phenotype, an increase in spontaneous locomotion, and improved endurance, indicating that they are not overweight and are even healthier in an ad libitum feeding environment. However, the knockout rats had reduced hippocampal volume, and the behavioral analysis suggested that they may have impaired cognitive function regarding novel objects. - Source: PubMed
Publication date: 2024/08/28
Uchimura YasuhiroHino KodaiHattori KosukeKubo YoshinoriOwada AiriKimura TomokoSugawara LuciaKume ShinjiBellier Jean-PierreYanagisawa DaijiroShiino AkihikoNakayama TakahisaDaigo YataroMashimo TomojiUdagawa Jun - Circular RNAs (CircRNAs) play essential roles in cancer occurrence as regulatory RNAs. However, circRNA-mediated regulation of gastric cancer (GC) remains poorly understood. - Source: PubMed
Publication date: 2024/02/24
Wu XinxinCao ChunliLi ZheXie YaoyaoZhang ShuangshuangSun WeiliangGuo Junming