Ask about this productRelated genes to: PPIB Blocking Peptide
- Gene:
- PPIB NIH gene
- Name:
- peptidylprolyl isomerase B
- Previous symbol:
- -
- Synonyms:
- CYPB, OI9, PPIase, B, CYP-S1, SCYLP
- Chromosome:
- 15q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-25
- Date modifiied:
- 2019-04-23
Related products to: PPIB Blocking Peptide
Related articles to: PPIB Blocking Peptide
- - Source: PubMed
Publication date: 2026/04/22
Chen LingWan ZimingGao XuejingChen ChaoGan Hua - The endoplasmic reticulum (ER) provides a specialized environment for the folding of secreted and membrane proteins, a process supported by many different chaperones. Among these chaperones, peptidyl-prolyl cis/trans isomerases (PPIases) catalyze a rate-limiting conformational step in protein folding, yet the principles governing isoform-specific function of PPIases remain poorly defined. Cyclophilin B (CypB), an ER-resident PPIase, has been implicated in early folding events, but whether its activity reflects biochemical adaptation to the ER environment is unclear. Here, we report the biophysical characterization of human CypB and compare it with the cytosolic isoform Cyclophilin A. Spectroscopic and enzymatic analyses show that CypB adopts the canonical cyclophilin fold and displays catalytic activity toward multiple substrates under both cytosolic- and ER-mimicking conditions, indicating that its enzymatic properties are not uniquely tuned to the ER milieu. Confocal imaging confirms that full-length CypB is enriched in the ER, and that removal of its N-terminal segment disrupts this localization. Together, these results indicate that subcellular localization, mediated by an N-terminal membrane anchor, rather than catalytic specialization, may define the physiological role of CypB. Our findings underscore compartmentalization as a central organizing principle of proteostasis in the secretory pathway. - Source: PubMed
DeVoe Sarah CYost Thomas CNewton Ashley JGrever Gavin AAyala Melissa FernandezGriffith Wendell PLatvala Robert DSchmidpeter Philipp A M - Bull-catching (vaquejada) accounting for approximately 13% of sport horses in Brazil. Genetic screening has enabled strategies to reduce the spread of inherited disorders, including Hereditary Equine Regional Dermal Asthenia (HERDA), a major skin disease included in the Six Panel required for registration by the Brazilian Quarter Horse Breeders Association. Although the HERDA-associated variant has been extensively studied in other disciplines, it had not been evaluated in Bull-catching Quarter Horses (QH). - Source: PubMed
Publication date: 2026/04/12
Caceres A MSperandio L M SAlvarenga N A C ABorges A SOliveira-Filho J P - - Source: PubMed
Publication date: 2026/04/12
Dong XueshanYu LuhangLi Yifan - Biliary atresia (BA) is a progressive disorder that aggravates liver inflammation and fibrosis in infants. Despite its clinical significance, the involvement of mitophagy in the pathogenesis and progression of BA remains poorly understood. Our study aims to explore mitophagy-related diagnostic model for BA. - Source: PubMed
Publication date: 2026/02/12
Sun DayanZhang JianguoZhao YongLi ShuangshuangZhang YananLiao JunminWang DingdingHua KaiyunGu YichaoDu JingbinZhang ShixuanHuang Jinshi