Ask about this productRelated genes to: TMEM75 Blocking Peptide
- Gene:
- TMEM75 NIH gene
- Name:
- transmembrane protein 75
- Previous symbol:
- -
- Synonyms:
- FLJ36105
- Chromosome:
- 8q24.21
- Locus Type:
- unknown
- Date approved:
- 2005-10-04
- Date modifiied:
- 2019-03-06
Related products to: TMEM75 Blocking Peptide
Related articles to: TMEM75 Blocking Peptide
- It has been reported that chromatin regulators (CRs), as one of the essential upstream regulators of tumor development, were screened to construct a prognostic model for predicting the outcome of tumor patients. However, the prognostic model based on CRs-related long noncoding RNAs (lncRNAs) in esophageal cancer (EC) has never been researched. This study aims to construct a novel CRs-related lncRNA signature to evaluate the prognostic ability of EC patients. We obtained the transcriptome data and clinical information of patients with EC from the Cancer Genome Atlas database, 870 CRs-related genes from previous topic research. Univariate, multivariate Cox, the least absolute shrinkage and selection operator regression analyses were used to establish the risk model. The receiver operating characteristic curve, principal component analysis, nomogram, quantitative real-time PCR were performed to evaluate the independence and accuracy of the model. The biological functions and immune microenvironment of the risk model were analyzed by gene set enrichment analyses and R softwares. A novel 3 CRs-related lncRNAs risk model composed of AC079684.1, TMEM75, LINC00365, as an independent and superior factor, was established for prognosis prediction of EC patients. Quantitative real-time PCR analysis verified upregulated AC079684.1 and TMEM75 mRNA levels and downregulated LINC00365 mRNA level in EC tissues compared with normal tissues. Gene set enrichment analysis analysis displayed Kyoto encyclopedia of genes and genomes and gene ontology pathways enriched in risk groups, such as focal adhesion, pathways in cancer, epidermal cell differentiation. Immune cells and immune checkpoints were more likely to be activated in the high-risk group. Finally, we found most of the compounds in the high-risk group exhibited higher sensitivity through therapeutic drug screening. The 3 CRs-related lncRNAs risk model could independently predict the prognosis of EC and provide immunotherapy guidance for patients with EC. - Source: PubMed
Wang YuchenShi ZhihuaSun XushengLiu Junfeng - Gastric cancer (GC) is one of the most important malignancies and has a poor prognosis. Copper-induced cell death, recently termed cuproptosis, may directly affect the outcome of GC. Long noncoding RNAs (lncRNAs), possessing stable structures, can influence the prognosis of cancer and may serve as potential prognostic prediction factors for various cancers. However, the role of copper cell death-related lncRNAs (CRLs) in GC has not been thoroughly investigated. Here, we aim to elucidate the role of CRLs in predicting prognosis, diagnosis, and immunotherapy in GC patients. - Source: PubMed
Publication date: 2023/06/08
Wang LiXiao KeDong ZhaogangMeng TaoCheng XiaowenXu Yuanhong - Colorectal cancer (CRC) is one of the most frequent cancers worldwide and leads to a great many deaths each year. However, the underlying mechanisms that regulate colorectal cancer development and progression remain elusive. Here we identified an uncharacteristic long noncoding RNA TMEM75 that was upregulated in colorectal cancer compared to non-tumor tissues. We found that TMEM75 expression levels are positively correlated with advanced clinical stage. TMEM75 significantly inhibited the proliferation, migration, and invasion of CaCo2 and HCT116 cells in vitro. Moreover, TMEM75 silence delayed tumor growth in vivo. Mechanistically, TMEM75 was demonstrated to initiate the expression of transcription factor SIM2. We also found that the expression of SIM2 was upregulated and positively correlated that of TMEM75 in colorectal cancer tissues. Furthermore, ectopic expression of SIM2 rescued TMEM75 depletion-induced inhibition on cell proliferation, migration and invasion in colorectal cancer. Altogether, our findings indicated that TMEM75 functions as an oncogene relying on activation of SIM2 in colorectal cancer for the first time. - Source: PubMed
Publication date: 2018/06/30
Jin XiaoyanLiu GuangmingZhang XiunaDu Na - Chromosome 8q24 is a region of compelling interest for prostate cancer (PRCA). Linkage, association, and admixture analysis initially indicated the region. Subsequently, several variants at 8q24 have been found to independently associate with PRCA. One compelling hypothesis is allelic heterogeneity, whereby multiple variants affect the regulation of the same gene. In addition to potential allelic heterogeneity, 8q24 exhibits strong linkage disequilibrium over vast distances and is prone to chromosomal aberrations. - Source: PubMed
Camp Nicola JFarnham James MAllen-Brady KristinaCannon-Albright Lisa A