Ask about this productRelated genes to: ABCB6 Blocking Peptide
- Gene:
- ABCB6 NIH gene
- Name:
- ATP binding cassette subfamily B member 6 (Langereis blood group)
- Previous symbol:
- -
- Synonyms:
- EST45597, umat, MTABC3
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2019-04-23
Related products to: ABCB6 Blocking Peptide
Related articles to: ABCB6 Blocking Peptide
- Multidrug resistance (MDR) remains a major obstacle in the clinical treatment of leukemia, severely limiting therapeutic efficacy and leading to poor patient outcomes. Drug efflux mediated by ATP-binding cassette (ABC) transporters represents a central mechanism driving cancer MDR. In this study, we identified ABCB6 as a critical mediator of MDR in leukemia through its role in promoting drug efflux. Using membrane-focused liquid chromatography‑tandem mass spectrometry (LC‑MS/MS) analysis of the leukemia cell line K562 and its MDR derivative K562/A02, we screened for differentially expressed transporters and identified ABCB6 as a candidate molecule. We further confirmed that ABCB6 is abundantly expressed on the plasma membrane of K562/A02 cells. Functional analyses demonstrated that altered ABCB6 expression did not significantly affect cell proliferation or apoptosis; however, targeted knockdown of ABCB6 markedly restored the sensitivity of K562/A02 cells to adriamycin (ADR) and cytosine arabinoside (Ara-C). Mechanistic studies revealed that ABCB6 contributes to ADR efflux from leukemia cells, thereby reducing intracellular drug accumulation and weakening its cytotoxic activity. Together, these findings establish ABCB6 as a previously unrecognized efflux transporter that contributes to MDR in leukemia and highlight ABCB6 as a potential therapeutic target for overcoming MDR. - Source: PubMed
Publication date: 2026/06/02
Jiao ZhongxiangYu HuasongZhang YiranYang MingZhang WenshanZhang HexiaoWang WeiZhang MingheLi XiaoyueLi YinghuiGao Yingdai - Combination therapies are critical for enhancing and prolonging the efficacy of EGFR inhibitors. Here, we uncover FUNDC1-dependent mitophagy as a key protective mechanism in EGFR-mutant non-small cell lung cancer (NSCLC). We discover that nitidine, a bioactive component of the traditional Xihuang Pill formulation, synergises with the EGFR inhibitor osimertinib. Mechanistically, nitidine and osimertinib synergistically disrupt FUNDC1-mediated mitophagy, leading to mitochondrial dysfunction and accumulation of reactive oxygen species in EGFR-mutant NSCLC. We further show that both osimertinib and nitidine decrease HIF-1α protein levels, thereby downregulating FUNDC1 expression. Nitidine-induced downregulation of HIF-1α and FUNDC1 depends on the mitochondrial transporter ABCB6. Notably, acquired resistance to osimertinib exhibits adaptive downregulation of FUNDC1, rendering resistant EGFR-mutant NSCLC cells more sensitive to nitidine. Collectively, these findings position nitidine as a promising therapeutic strategy to enhance the efficacy of EGFR inhibitors and overcome osimertinib resistance in EGFR-mutant NSCLC. - Source: PubMed
Xu FanWang XiaoshanLi MinLi YiLi XiaojuanYan QingqingKong FanmingHuang QihongCao XinXue Ying - Spodoptera frugiperda is a major global pest that affect multiple crops, mainly corn and rice. Unfortunately, this pest has evolved resistance to various chemical and biological pesticides. ATP-binding cassette (ABC) transporters, particularly members of the B subfamily, are associated with detoxification by exporting xenobiotics and plant-derived metabolites from the intoxicated insect cells. In addition, some are involved in the mode of action of Bacillus thuringiensis biopesticide Cry toxins, functioning as receptors for these proteins. In this study, we analyzed transcriptomic data from the midgut tissue of S. frugiperda and identified the ABCB6 as one of the most highly expressed transporters within the ABCB subfamily. To explore its functional role, we generated a CRISPR-Cas9 knockout (KO) mutation. Strikingly, loss of SfABCB6 conferred resistance to the chemical pyrethroid insecticide cypermethrin, while the susceptibility to B. thuringiensis Cry1Ab, Cry1Fa and Vip3Aa toxins remained unchanged. Consistently, the ABCB6 CRISPR-Cas9 KO in S. frugiperda derived Sf9 cells conferred resistance to cypermethrin, reiterating the observed larval phenotype. In contrast, the overexpressing of ABCB6 in Sf9 cells exhibited increased susceptibility to cypermethrin. However, SfABCB6 KO showed fitness costs in the insect, as this mutation drastically reduced fertility. Our results provide evidence that SfABCB6 transporter facilitates cypermethrin toxicity participating in insecticide resistance and pointing out its potential role as a novel target for pest management strategies. - Source: PubMed
Publication date: 2026/03/13
Quintana Adrián JGarcía-Suárez RosalinaPrieto AdriánSánchez JorgeGómez IsabelVerduzco-Rosas Luis AdoNascimento NathalyLopez-Molina SamiraZhang JieSoberón MarioBravo AlejandraPacheco Sabino - Strict homoeostatic control of potassium is necessary for normal muscle and neural function, and as a result, hyperkalaemia can be life-threatening and requires timely management. Prior to treating the patient, however, it is important to determine if hyperkalaemic blood test results are authentic and not due to pre-analytical factors as treatment in this context may provoke potentially dangerous hypokalaemia. We present the case of a 47-year-old female referred for further investigation following 2 years of otherwise unexplained intermittent hyperkalaemia. Her highest recorded potassium was 8.9 mmol/L (reference interval: 3.5-5.2 mmol/L). She was otherwise healthy, not on regular medications, and asymptomatic during these episodes. There was no evidence of associated electrocardiogram (ECG) changes. She had been referred to the Emergency Department twice in 6 months due to hyperkalaemia, but these episodes resolved on repeat testing without any intervention. Further investigation revealed a significant time- and temperature-dependent increase in potassium concentration in whole blood samples, compared to a control. single gene testing revealed a heterozygous variant, c.1123 C>T, p. (Arg375Trp), consistent with a diagnosis of familial pseudohyperkalaemia (FP). This is an autosomal dominant condition, which results in increased efflux of potassium from red blood cells at sub-physiological temperatures. Whilst this is an phenomenon, unless recognised it poses a clinical risk to patients as they may be treated erroneously. - Source: PubMed
Publication date: 2026/02/10
Rodney MeganRankin KellyButler JennyThompson SimonFlorkowski Chris MKing Richard I - Dyschromatosis universalis hereditaria (DUH) is a rare type of autosomal dominant inheritance disease. It has varying gene mutation sites among different ethnicities. and have been identified as the causative genes of this disorder. - Source: PubMed
Wang Xue-LianZou TongWu Yi-ChengWeng You-YiYao QiangSun Wei-Wei