Ask about this productRelated genes to: SLC25A32 Blocking Peptide
- Gene:
- SLC25A32 NIH gene
- Name:
- solute carrier family 25 member 32
- Previous symbol:
- -
- Synonyms:
- MFTC
- Chromosome:
- 8q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-10-03
- Date modifiied:
- 2016-02-18
Related products to: SLC25A32 Blocking Peptide
Related articles to: SLC25A32 Blocking Peptide
- Solute carriers (SLCs) mediate cell- and organelle-specific import and export of nutrients and metabolites required for every biochemical process that occurs in a cell. Functional studies have ascribed activities to many human genes annotated as SLCs, but more than 100 SLCs remain orphans. Here, we applied a set of computational tools to characterize the orphan carriers SLC35F4 and SLC35F5. Phylogenetic analysis grouped SLC35F4 sister to SLC35F3, a suspected thiamine transporter, in a clade with SLC35F5, and distinct from an SLC35F6/2/1 clade. Transcriptome datasets revealed a restricted function for SLC35F4 in the cerebellum, in contrast to the more widespread distribution of SLC35F5. Gene ontology identified the Golgi apparatus as the likely residence of both transporters. Conceptual docking of 71 candidate substrates predicted high affinities of SLC35F4 (10-40 nM) and SLC35F5 (0.1-0.4 nM) for flavin adenine dinucleotide (FAD), straddling that of the known FAD transporter SLC25A32 (2-4 nM), while returning much lower affinities (by 30-fold or more) for all other tested substrates. Docking to SLC35F3 returned low affinity for both FAD and thiamine as candidate substrates. Thus, SLC35F4 and SLC35F5 but not closely related SLC35F3 likely import FAD into the Golgi apparatus, where the cofactor serves as the oxidant for disulfide-bond formation during tissue-specific, post-translational modification of secretory proteins. These findings provide strong direction for the definitive experiments yet needed to confirm the carriers' subcellular localization, transport activities, and contributions to protein maturation and trafficking. - Source: PubMed
Publication date: 2026/01/04
Niu ZheyunJiang DongmingHardy Daniel M - Colorectal cancer (CRC) remains the third leading cause of mortality among cancer patients in developed countries. Each new study in this field can contribute to better detection, diagnosis, and treatment of this disease. Our study aimed to assess transcriptional activity of genes associated with the biotransformation of xenobiotics and endobiotics in all three phases in the CRC , including correlations between them, as well as the aromatic hydrocarbon receptor (AhR) pathways. Based on transcriptome analysis (1252 mRNAs) of the CRC tissue and healthy colon, the upregulation or downregulation of 46 significant mRNAs was presented. The study also revealed the downregulation of and upregulation of and , previously undistinguished and potentially therapeutically valuable in CRC. The diagnostic potential of , , , and was demonstrated. It was stated that the , , , and did not correlate in healthy intestinal tissue whereas , , , , , and did not correlate in CRC. The disturbed transcriptional activity of genes related to the biotransformation process at all stages of CRC suggests that this may be the cause of its occurrence; the genes ought to be taken into account in preventive strategies and the treatment of patients. - Source: PubMed
Publication date: 2025/12/16
Janikowska GrażynaJanikowski TomaszKuźbińska AleksandraOpiłka MieszkoMazurek UrszulaLorenc Zbigniew - This study provides a comprehensive tissue-specific transcriptomic analysis of mitochondrial genes associated with vitamin metabolism in buffalo. Using RNA-seq data from four post-pubertal female buffalo tissues (kidney, heart, brain, and ovary), we profiled 41 nuclear-encoded mitochondrial genes involved in the metabolism of B-complex vitamins, vitamins A, C, D, folate, choline, and one-carbon pathways. The kidney exhibited the highest expression of biotin-related genes (ACACB, PC, PCCA), supporting roles in fatty acid oxidation and gluconeogenesis, while the heart showed moderate expression, and the brain and ovary lower expression, consistent with their metabolic functions. In vitamin A metabolism, the kidney showed elevated transcription of AKR1B10 and BCO2 (retinoid detoxification), whereas the heart exhibited moderate RDH14 expression, and the brain and ovary showed minimal transcriptional activity. Vitamin D-related genes were highly expressed in the kidney (FDX1) and ovary (FDXR), with lower expression in heart and brain. Vitamin B6-associated genes were prominently expressed in the ovary (PLPBP) and kidney/brain (PNPO), with low expression in the heart. B12-processing genes (MMAA, MMAB, MMADHC) showed the highest expression in the kidney, followed by the heart. The thiamine transporter SLC25A19 was transcriptionally enriched in the ovary, with moderate expression in kidney and brain. Riboflavin metabolism genes (RFK, FLAD1, SLC25A32) were more highly expressed in the kidney and heart, while choline and betaine metabolism genes (DMGDH, CHDH, SARDH) and one-carbon metabolism genes (ALDH1L1, AMT, SFXN1) were predominantly expressed in the kidney. Overall, this transcriptomic evidence reveals organ-specific expression patterns of vitamin-dependent mitochondrial pathways in buffalo, offering insights for nutritional strategies to enhance livestock metabolic efficiency and contributing to the broader understanding of mammalian mitochondrial physiology. - Source: PubMed
Publication date: 2025/12/29
Sadeesh E MLahamge Madhuri SSingh PratikshaMohiddin Roshan - The gene plays a pivotal regulatory role in one-carbon metabolism and redox balance by functioning as a transporter for tetrahydrofolate and flavin adenine dinucleotide (FAD). The probable contribution of toward facilitating the proliferation of cancerous cells remains inadequately explored. This pilot study aims to survey the expression of in non-metastatic colorectal tissues and its potential association with clinicopathological characteristics. Fresh tissue samples were collected from 30 colorectal cancer patients and their adjacent normal tissues. Total RNA was extracted, and cDNA was synthesized for qRT-PCR. In silico analysis was also performed to further investigate the functional significance of SLC25A32 in colorectal cancer by examining its expression in normal tissues, identifying protein interactions, and searching for pathogenic mutations. Our results revealed a significant up-regulation of expression in tumorous tissues compared to non-tumorous tissues. The elevated expression of was associated with tumor anatomic site and size. In silico analysis revealed that higher levels of expression were correlated with reduced overall survival rates. Furthermore, enrichment analysis showed that this gene remarkably enriched in the process of Folate metabolism. The involvement of SLC25A32 in tumorigenesis may be due to its regulation of mitochondrial folate and FAD metabolism, which have been linked to cancer progression. Changes in SLC25A32 expression or function may contribute to cancer development, making it a potential therapeutic target for cancer treatment. - Source: PubMed
Publication date: 2024/06/05
Hashemi MehdiTahmasebi-Birgani MaryamTalaiezadeh AbdolhassanSaberi Alihossein - Mineral elements are crucial for biological functions, with meat serving as a key dietary source. Despite advances in ionome analysis, the genetic mechanisms regulating mineral accumulation in meat remain poorly understood. Here, we analyze the ionome of 376 breast muscles from the large gradient consanguinity segregating population generated by Pekin duck × Liancheng white duck crosses, quantifying 7 essential mineral elements (potassium (K), phosphorus (P), sodium (Na), magnesium (Mg), calcium (Ca), iron (Fe), and zinc (Zn)). Notably, Ca exhibited the most pronounced variation between Pekin duck and Liancheng white duck (fold change = 1.83, P < 0.01). Correlation analysis demonstrated significant positive relationships between Zn and Ca (r = 0.49), Na (r = 0.41), and (all P < 0.001), while negative correlations were observed between Na and K (r = -0.29) (P < 0.001). We then analyzed correlations between the ionomic profiles and growth and meat quality traits. Importantly, Ca concentrations showed strong negative correlations with both breast muscle thickness (r = -0.72) and body weight (r = -0.76) (both P < 0.01), but positively correlated with meat lightness (r = 0.54, P < 0.01). To elucidate the genetic architecture underlying the duck pectoralis muscle ionome, we first estimated its narrow-sense heritability, which ranged from 0.19 to 0.58 across different mineral elements. Through comprehensive genetic analyses incorporating genome-wide association studies, linkage disequilibrium mapping, gene annotation, and expression profiling, we identified 2 key genes (SLC25A25 and ATP2B2) on chromosomes 18 and 13 that collectively regulated Ca content. These lead single nucleotide polymorphisms in these loci explained 39.91% and 11.07% of the phenotypic variance, respectively. Notably, the lead SNP on Chr18 also demonstrated pleiotropic effects, contributing to both meat lightness (PVE = 14.79%) and breast muscle thickness (PVE = 1.79%). Furthermore, on chromosome 2, we discovered a significant SNP associated with both Na and Ca concentrations, accounting for 12.6% and 4.35% of phenotypic variation, respectively. Further analysis pinpointed gene SLC25A32 as the most promising candidate within this genomic region. These findings enhance our comprehension of the genetic basis underlying ion content in meat and offer valuable insights for refining breeding programs, while also providing a new direction for the combat hidden hunger through meat biofortification. - Source: PubMed
Zhang HeYu DaxinLiu DapengTang HeheLiu TongGuo ZhanbaoLiu HongfeiWang ZhenMu QimingLiu SiruiZhang YongfuHou ShuishengZhou Zhengkui